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Biomedical subjects

P Grünwald

Publications and source records attributed to P Grünwald.

13 recordsLinked to original sources
PubMed2000

Model Selection Based on Minimum Description Length.

We introduce the minimum description length (MDL) principle, a general principle for inductive inference based on the idea that regularities (laws) underlying data can always be used to compress data. We introduce the fundamental concept of MDL, called the stochastic complexity, and we show how it can be used for model selection. We briefly compare MDL-based model selection to other approaches and we informally explain why we may expect MDL to give good results in practical applications. Copyright 2000 Academic Press.

Journal Article↗
PubMed1998

[Postoperative results of stapes revision].

BACKGROUND: In this retrospective study indications, intraoperative findings, reconstruction techniques and postoperative hearing results in revision stapes surgery were evaluated. PATIENTS: Between March 1988 and January 1996, 150 patients underwent stapes revision. Indications for surgery were the presence of conductive hearing loss (132), dizziness (12), sensorineural hearing loss (3), deafness (2), and tinnitus (1). RESULTS: Intraoperative findings were lateral migration of the implant, regrowth of bone in the oval window niche, erosion of incus, cholesteatoma, and others. In most cases a new prosthesis (gold piston) was inserted between incus and vestibulum. In cases with incus erosion, a malleovestibulopexy was performed. Seventy-three percent of patients who underwent revision stapes surgery because of conductive hearing loss showed a hearing improvement of 20 dB or more. All patients who underwent revision stapes surgery because of dizziness reported an improvement of their symptoms postoperatively. CONCLUSIONS: Revision stapes surgery should be approached by experienced surgeons, because the risk of severe sensorineural hearing loss is higher than at the time of primary stapedectomy. Informed consent is mandatory.

Adolescent↗
PubMed1982

[ECG during rest as an indicator of vascular changes in diabetic patients].

EKG-findings of 186 non-selected diabetic outpatients and 52 control subjects of the age group of 50 to 79 years have been examined in relation to cardiovascular risk factors as well as to peripheral vascular disease (PVD) and carotid artery stenosis (CS). The Whitehall-Criteria of the Minnesota-Code were seen in diabetics (D) approximately twice as frequently as in non-diabetics (C): Minnesota-Code I: D 7% vs C 4%; IV 27% vs 13%; V 25% vs 15%; VII1 2% vs 0%. Beside higher levels of blood glucose and HbAI, diabetics differed from controls mainly by higher systolic blood pressure (p less than 0.001). Furthermore, they showed more signs of PVD and CS. Only in 27% of diabetics normal EKG-findings were seen. In comparison to age-adjusted diabetics with EKG-abnormalities, these patients showed signs of PVD and CS only to a minor degree and lower values were found for systolic (p less than 0,01) and diastolic (p less than 0.05) blood pressure, weight (p less than 0.05), serum triglycerides (p less than 0.02), and markedly higher values for HDL-cholesterol (p less than 0.01). These data show that in diabetics more frequently abnormal EKG-findings are seen and that a normal EKG in diabetics older than 50 years indicates low cardiovascular morbidity and a favorable risk factor profile.

Adult↗
PubMed1976

[A serogenetic approach to the study of Alzheimer's disease (author's transl)].

The analysis of 15 hereditary controlled blood characteristics in 57 Alzheimer-patients revealed abnormalities in the distribution of ABO-blood-groups and phenotypes in the third component of complement system. These data indicate that the phenogenesis of the Alzheimer syndrome is multiconditional and is obviously influenced by selective processes of immuno-genetic factors. This selective vulnerability offers a lead into the elucidation of amyloid deposition in Alzheimer's disease.

ABO Blood-Group System↗