[Effect of pregnancy on Recklinghausen's disease].
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Adolescent↗
Biomedical subjects
P Goudet
Publications and source records attributed to P Goudet.
Transplantation of human cryopreserved adenomatous and hyperplastic parathyroid tissue to the hypocalcemic nude mouse.
Cryopreserved parathyroid glands from patients operated on for hyperparathyroidism were stored for further auto- or allografting. In an attempt to better use cryopreserved parathyroid glands in humans, we designed a study whose goal was to compare human parathormone (hPTH) secretion from cryopreserved parathyroid glands with regard to tissue histology (adenoma or hyperplasia), mass, and time of storage in hypocalcemic Nude mice and to be able to better use them in humans. A new hypocalcemic experimental model, using parathyroidectomized Nude mice was set up. Hypocalcemic mice received calibrated grafts from human parathyroid glands cryopreserved between 1982 and 1992 originating from 30 patients (15 adenomas, 15 hyperplasias). Each parathyroid was grafted into two mice under the ratio of one mass-unit (12 mg) and three mass-units (36 mg). The hPTH concentration was assessed by an immunoradiometric method 21 days after grafting. The mean cryopreservation time was 677 days (54-3187 days). The time of cryopreservation was identical in the two kinds of tissue (p = 0.88). The hPTH concentration in 59 living mice was 72.2 +/- 271.4 (SD) ng/ml (3-1936 ng/ml). This concentration was 7.1 +/- 4.3 ng/L for adenomas versus 139.4 +/- 378.6 ng/L for hyperplasias (p = 0.003) and 87.1 +/- 352.6 ng/L for one-unit-mass grafts versus 56.7 +/- 152.5 ng/L for three unit-mass grafts (p = 0.824). Hyperplastic glands showed more secretion, which was confirmed in both mass related groups (p = 0.02, p = 0.006).(ABSTRACT TRUNCATED AT 250 WORDS)
Adenoma↗
Intra-abdominal gastric volvulus. An indication for gastropexy through laparoscopy.
Intra-abdominal gastric volvulus is a chronic or acute condition that may be cured by conventional surgery through laparotomy. We report a case of subacute intra-abdominal volvulus who benefited from a gastropexy through laparoscopy. We show that this technique is feasible, safe and efficient. Technical details are described to perform the procedure easily and rapidly.
Aged↗
[Endothoracic goiter operated on by cervicosternotomy. Apropos of 18 cases].
From 1968 to 1992, 18 sternotomies were performed on a total amount of 225 operated substernal goiters (8% of cases). These operations concerned 14 females and 4 males aged of about 67.8 years. 7 patients had already been operated of a goiter within 1 to 50 years. The substernal goiter was discovered on a systematic x ray chest 5 times, and a x-ray scanner once, also clinical symptoms were still present with compressive troubles in 16 times (particularly acute dyspnea 3 times). The sternotomy was always total. It was only required if the operative problems were important at the time of the cervicotomy. Indications for sternotomy were:--impossibility to extraction due to the volume of the goiter 10 times, (including 5 recurrent goiters), independent retrosternal goiter without cervical connexion, 2 times (including 2 recurrent goiters), hemorrhagic linkage, 3 times, invasive cancer, 3 times. Excluding the 3 invasive cancers, the mortality was inexistant and the morbidity very low, especially without respiratory problems. Post operative complications were 2 definitive hypoparathyroidism and 1 regressive recurrential palsy (plus 2 recurrential palsy still present before the operation). The authors pointed out the good tolerance of the sternotomy which, in special case, should be absolutely preferable the cervicotomy alone, in order to reduce the operative risks, especially hemorrhagic and nervous.
Aged↗