Daily fluctuation (circadian and ultradian) in biogenic amines of the rat brain.
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Biomedical subjects
Publications and source records attributed to P Gordon.
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The present article examines whether derivational morphology shows evidence of an associative memory structure. A distributional analysis of stems of attested derivational forms revealed evidence of clustering around phonological properties (gangs) for all nonneutral affixes but only a few neutral affixes. Subjects' acceptability ratings for novel complex words revealed sensitivity to the gang structure associated with the relevant derivational affixes. Results suggest that, like inflectional morphology, derivational morphology shows dissociations between rule-based and associative generalization mechanisms.
A central question in morphological research is whether there are whole-word representations for regularly inflected forms. A series of four lexical decision experiments addressed this question by looking at whole-word frequency effects across a range of frequency values with constant stem-cluster frequencies. Frequency effects were only found for inflected forms above a threshold of about 6 per million, whereas such effects were found for morphologically simple controls in all frequency ranges. We discuss these data in the context of two kinds of dual models and in relation to competition models proposed within the connectionist literature.
UNLABELLED: Posttransplant lymphoproliferative disorder (PTLD) is a well-known complication after pediatric transplantation. We analyzed all potential risk factors to assess patient and graft outcomes of 119 children who received intestinal transplantations. MATERIALS AND METHODS: Between August 1994 and March 2005, 119 patients underwent cadaveric intestinal transplantation. Their median age at transplant was 1.4 years (range: 0.6-17), median weight was 9.5 kg (range: 4.7-67), and 57% were boys. The median follow-up among 49 ongoing survivors was 41 months (range: 4-121). All PTLD cases were biopsy proven. In the past 5 years, treatment included antiviral therapy, immunosuppression withdrawal, and use of rituximab. RESULTS: The incidence of PTLD was 11.8% (14/119). No patient experienced graft failure secondary to PTLD, while two patients died from PTLD (14.2%). The PTLD group was divided into an early onset group (<4 months, 6 of 14; 42.8%) and a late onset group (>2 years, 8 of 14; 57.2%). No patient experienced PTLD between 4 months and 2 years after transplantation. The use of OKT3 was the only significant risk factor for the development of PTLD. No factor was specifically associated with the early versus late development of PTLD. CONCLUSIONS: The only factor associated with a significantly higher risk of PTLD was the use of OKT3 to treat a rejection episode. Finally, since the the introduction of anti-CD20 antibodies as part of the treatment protocol for PTLD, the risk of death due to PTLD appears to have become manageably low.
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Poor diet and physical inactivity contribute to many chronic diseases in the United States each year. Diets low in saturated fatty acids and cholesterol and high in plant foods, i.e., fruits and vegetables, legumes and whole cereals, are protective. Physically active lifestyles are associated with lower risk of cardiovascular diseases, diabetes, obesity and some cancers. To access diet and physical activity levels in West Virginians, we conducted a study which was supported by the West Virginia Bureau for Public Health and the West Virginia University Prevention Research Center (CDC Cooperative Agreement). The purposes of this study were to estimate the proportion of the sample meeting recommendations for chronic disease prevention, and to examine if the individuals who were meeting the Surgeon General's physical activity recommendation for health are also consuming healthier diets. Our results showed that reducing saturated fatty acids and increasing consumption of folate, Vitamin E, calcium and fiber are of prime public health importance in West Virginia. Diet and activity levels were modestly related, suggesting that those who adopt a healthy diet also become more active and vice versa. Due to the cross-sectional nature of this data, it is unknown if single-strategy or dual interventions work best. Prospective studies are needed to determine optimal strategies.
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This study investigated colposcopy training in family practice residency programs, using a national survey of all 376 residency program directors. Responses were received from 75% of the directors; 59% provided colposcopy training, and 40% of the programs not providing the training were in the process of developing a training experience. There was a regional difference in programs providing training; those in the northeast were least likely to provide training and were also least likely to be actively integrating training into their curricula. The three most common barriers to colposcopy training were lack of trained faculty, equipment costs, and inadequate patient volume.
People continue to travel without wearing seat belts despite their proven safety value. Numerous interventions in primary care physicians' offices to enhance the use of seat belts have met with limited success. In a rural neighborhood health center, an intervention using the language of self-responsibility was evaluated. Of 105 patients receiving the intervention, seat belt use increased from 20% before to 35.2% after the intervention (P less than .001). No change in seat belt use occurred in a control group of patients who did not receive the intervention.
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