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Biomedical subjects

P Gold

Publications and source records attributed to P Gold.

At least 73 records · Page 4Linked to original sources
PubMed1981

Effects of vasopressin on human memory functions.

Arginine vasopressin and a number of its synthetic analogs augment memory functions in experimental animals. One of these analogs, 1-desamino-8-D-arginine vasopressin (DDAVP), influences human learning and memory. Cognitively unimpaired, as well as cognitively impaired adults, treated with DDAVP for a period of several days, learn information more effectively, as measured by the completeness, organization, and consistency (reliability) of recall. DDAVP also appears to reverse partially the retrograde amnesia that follows electroconvulsive treatment.

Adult↗
PubMed1981

Tricyclic antidepressants do not alter thyroid hormone levels in patients suffering from a major affective disorder.

Abnormalities of thyroid function have been associated with affective disorders, and treatment with thyroid hormones or drugs that alter thyroid hormone levels can change the course of an affective disorder. Therefore, we investigated the possibility that mood-altering effects of tricyclic antidepressants would be mediated by alterations in thyroid hormones (T3 and T4) levels. In a group of 11 patients with affective disorders, tricyclic antidepressants did not alter serum T3 and T4 levels. We conclude that the mood-altering potency of tricyclic antidepressants, and particularly their potency to induce rapid mood cycles, is not due to changes in total T3 and T4 serum levels.

Adolescent↗
PubMed1980

The isolation of the gamma subunit of fetal hemoglocin (HbF) and its use in a radioimmunoassay for HbF.

A method is described for the purification, from fetal hemoglobin (HbF), of the fetal specific globin chain (gamma chain) in its native state. In the absence of alpha chain (the globin chain common to all adult human hemoglobins) gamma chain, when used as an immunogen, is able to express its unique antigenicity. Here, a specific, high titer antiserum raised against gamma chain has been used to establish a sensitive radioimmunoassay for HbF. This approach may be applicable to the measurement of other normal and abnormal hemoglobins.

Absorption↗
PubMed1980

Historical development and potential uses of tumor antigens as markers of human cancer growth.

During the past 30 years, the rapidly developing and changing concepts and technology of the discipline of immunobiology have been applied to studies in oncology. After the definitive demonstration of so-called tumor-specific transplantation antigens in chemically and virally induced tumors in syngeneic rodent and murine species, numerous efforts were then directed toward the demonstration of comparable materials in human tumors. After a number of false starts in an overzealous search for a marker that would serve as a panacea for human cancer diagnosis, more rational approaches have been taken to the problem and valuable information from the points of view of both the cell biologist and clinical oncologist has been forthcoming. The present paper presents an overview of human tumor antigens as biological markers of tumor growth. Reference is made to the fact that normally occurring biological materials of known function that are qualitatively and/or quantitatively altered during the process of malignant transformation may be most useful in the diagnosis and management of the cancer patient. The role of the presently available radioimmunoassays for carcinoembryonic antigen in clinical medicine is outlined.

Acid Phosphatase↗
PubMed1980

The effect of growth hormone administration on human sleep: a dose-response study.

Human growth hormone and saline were administered for one night each to normal volunteers in a cross-over study. A dose of 2 units im given 15 min before bedtime had no effect on sleep EEG parameters. In contrast, 5 units resulted in a 19% decrease in slow-wave sleep (p < 0.01) and a 13% increase in REM sleep (p < 0.05). Neither doe, when given during daytime, affected tests of affect or serial learning.

Adolescent↗
PubMed1979

Absence of carcinoembryonic antigen-like material in mesothelioma: an immunohistochemical differentiation from other lung cancers.

This study is to examine the potential usefulness of immunohistochemical staining for carcinoembryonic antigen (CEA)-like material in the differential diagnosis of mesotheliomas (12 cases) from other lung cancers (14 cases) that had been previously diagnosed by transmission and scanning electron microscopy and conventional light microscopy. Indirect immunofluorescent staining for CEA was carried out on formalin-fixed paraffin-embedded sections, and the slides were examined under code. All 9 cases of diffuse mesothelioma were negative, and all 12 cases of adenocarcinoma and bronchioloalveolar carcinoma were positive for CEA-like material. Three localized mesotheliomas and a carcinoid tumor were also negative. A squamous cell carcinoma was positive. A positive immunohistochemical result for CEA-like material in lung cancers will raise the possibility of its being of bronchial epithelial origin.

Adenocarcinoma↗
PubMed1979

Immunohistopathologic study on carcinoembryonic antigen (CEA)-like material and immunoglobulin A in gastric malignancies.

Immunofluorescent staining for carcinoembryonic antigen (CEA)-like material and immunoglobulin A (IgA) was performed on 54 gastric specimens showing normal mucosa and various lesions including malignancy. Both CEA-like material and IgA were demonstrated in normal mucosa and benign and malignant epithelial lesions. Abnormal findings in respect to CEA-like material included staining of cell membranes with disordered pattern and increased cytoplasmic staining. Several staining characteristics for CEA-like material were shown by various types of malignant epithelial tumors. This staining provides a means of distinguishing anaplastic carcinoma from histiocytic lymphoma, as the latter does not demonstrate CEA-like material. IgA was consistently absent in anaplastic carcinomas, but was noted on the inner surface of tubular components in the differentiated adenocarcinomas, indicating functional preservation in the differentiated tumors. Immunohistochemical staining for CEA-like material and IgA is considered to be useful in the structural and functional study of gastric malignancies.

Adenocarcinoma↗
PubMed1979

Prediction of the academic success of children with suspected neurological impairments.

Explored a multivariate approach to the prediction of 8-year academic achievement. Ss were black, of low socioeconomic status, and had been diagnosed as suspect neurologically impaired at age 7. A serial array of early predictors that included maternal education, sex, birth weight, 8-month and 4-year intelligence, and 3-year speech, hearing, and language were entered into multiple regression analyses to determine their value in predicting 8-year academic achievement in word recognition, arithmetic, spelling, and oral reading. The 4-year intelligence measure was the best overall predictor, although maternal education, sex, and birth weight contributed slightly to the predictions. The resulting equations, however, could not be used to predict accurately 8-year academic achievement.

Achievement↗