Biomedical subjects

P Glass

Publications and source records attributed to P Glass.

53 records · Page 3Linked to original sources

PubMed1976

Hemodynamic changes associated with angina pectoris induced by maximal treadmill exercise: effect of sublingual isosorbide dinitrate on systolic time intervals.

A technique for the study of patients with angina pectoris has been described, in which systolic time interval (STI) measurements are obtained at intervals after the onset of stress-induced angina. The technique is uniquely suited to the evaluation of anti-anginal drugs. Sublingual isosorbide dinitrate (SISD) was randomly alternated with a placebo (P) tablet in a double-blind study of 20 patients with stable angina pectoris. After SISD, compared to placebo, a highly significant shortening of Q-S2 and LVET occurred (p less than 0.001) which lasted throughout the entire 120 minute study period. The hemodynamic basis for these differences was felt to be improved myocardial contractility secondary to a reduction in systemic vascular resistance and reduced venous return induced by the SISD. A significant prolongation of PEP occurred at 60 minutes post-SISD (p less than 0.01). This was attributed to an increase in the gradient between LVEDP and aortic diastolic pressure resulting from reduced venous return after SISD. The PEP/LVET ratio was significantly increased up to 60 minutes after SISD (P less than 0.05). Heart rate was uniformly higher post-SISD, compared to post-placebo values; the differences were highly significant up to 60 minutes (P less than 0.001) and remained significant at 120 minutes (p less than 0.05). The time to angina was significantly longer (immediately post SISD, p less than 0.05; 30 min, p less than 0.001; 60 mins, p less than 0.05; 120 mins, p less than 0.05); and the work load greater, for 120 minutes following SISD: the increase in the latter was highly significant for 30 minutes after SISD (p less than 0.001) and remained significant up to 120 minutes (60 mins, p less than 0.05; 120 mins, p less than 0.05). These observations were attributed to an improvement in myocardial function due to the sublingual isosorbide dinitrate. A high degree of correlation was found to exist between heart rate and the STI. This correlation was negative for the QS2 interval (-0.996) and LVET (-0.993) and positive for PEP (+0.817) and the PEP/LVET ratio (+0.950).

Aged↗

PubMed1976

The bronchodilator effects of terbutaline: route of administration and patterns of response.

The effectiveness and clinical indications of Terbutaline as a bronchodilator were analyzed by the subcutaneous, oral and aerosol route in 56 patients. A significant improvement in air flow rates both in major and smaller airways was achieved by all routes of administration. The inhalation route offered the fastest onset of action, maximal response and longest duration. Similar trends, but of decreased magnitude, were seen following the subcutaneous and oral routes. Overall analysis of results did not indicate a definite dose-response dependency within the aerosol and oral routes at the tested dosages, whereas the incidence of side effects was clearly dose-dependent. On this basis it is recommended that for maintenance therapy treatment should begin with oral Terbutaline 2.5 mg every 6-8 hours and this dose be adjusted according to the clinical response. For the treatment of acute bronchospasm 0.50 mg or 0.25 mg subcutaneously, or a dose as low as 0.375 mg by aerosol, would be highly effective within five minutes. A combination of oral and aerosol administration represents a highly effective synergistic combination for most clinical situations requiring maintenance therapy.

Administration, Oral↗

PubMed1975