Biomedical subjects

P Ghezzi

Publications and source records attributed to P Ghezzi.

At least 181 records · Page 10Linked to original sources

PubMed1980

Effect of oral monosodium glutamate on glutamic acid levels in the nucleus arcuatus of the hypothalamus and on serum osmolality of adult and infant mice.

Monosodium glutamate (MSG) given by gavage to 7-day-old mice at 2 g/kg body weight (b.wt.) as a 20% solution w/v resulted in a 27% increase in the glutamic acid (GA) content in the nucleus arcuatus of the hypothalamus (NAH). When MSG was administered by gavage to adult mice at 4 g/kg b.wt. as a 20% solution w/v, GA levels in NAH remained unchanged. Serum osmolality, measured after oral MSG, was elevated in infant mice but was unaffected in adults.

Animals↗

PubMed1980

Plasma glutamic acid levels in premature newborn.

24 premature, newborn infants were investigated for plasma glutamic acid (GA) levels before and after a normal milk feed, to ascertain if the ingestion of GA present in the milk could result in an increase of its plasma level. No increases were detected in plasma between 5 and 90 min after the feed. These results may be important in respect to the problem of the possible toxicity of monosodium glutamate (MSG) added to baby foods.

Animals↗

PubMed1977

[Conductivity of the dialysis bath. Measurement, significance and electrolyte and clinical correlations].

The problem of the conductivity of dialysing solution is discussed. Measurement technique is analysed, highlighting the possibility of error connected with variations in the temperature of the dialysis bath, its mixture, the presence of air bubbles and the presence of dissolved substances that are not electrical charge carriers, and stressing the absolute proportionality with free ions and not with total ions. On the basis of these observations, the lack of any real, reliable correlation between conductivity and electrolytic composition of the dialysing solution unless particular conditions are respected is pointed out. Most important of these are exact knowledge of the composition of the mother solution and the degree of purity of the water. In conclusion, the imprecision of the values given by clinical and technological tradition and widely accepted is pointed out. Such values do not correspond to correct measurement.

Electric Conductivity↗

PubMed1977

[Attempt to solve technical problems involved in the re-utilization of coil filters for hemodialysis].

The problem of the reutilization of coil filters in haemodialysis is discussed. The methodologies in current use are examined and the technical risks and inconveniences that limit any real economic advantage are pointed out. On the basis of these observations, a system of reutilization is proposed which does not call for any direct handling of the filter nor any special techniques for eliminating risks of transmitting infection, and cuts to the minimum extra work involving the use of hospital staff. The proposed equipment is illustrated in detail. It consists of a small accessory individual monitor which has opened the way to the concept of "weekly dialyser". Attention is called to the need for further research into the physiopathology of the regenerated membrane, particularly in relation to the type of filter, the number of reutilizations, and the behaviour of ultrafiltration and the various solutes.

Acute Kidney Injury↗

PubMed1977

[Studies on the ultrafiltration in coil-type dialysers for recirculation].

Ultrafiltration in recirculating coil dialysers is discussed. The difficulty of determining the exact transmembrane pressure is stressed. The data normally available are insufficient and take no account of the direction of recirculation, which may be a determining factor. Input and output dialysing fluid pressure were measured in vitro and the respective ultrafiltration values were compared with those observed clinically. Calculation of the mean blood pressure in the dialyser circuit is examined. If determined from the simple arithmetical mean between the input and output pressure, this does not reflect the real situation inside the filter. It is thus unreliable when used to calculate the real transmembrane pressure, and hence the ultrafiltration.

Humans↗

PubMed1977

[Acute hemodialysis with a single needle].

The problems of vascular access in acute haemodialysis are illustrated in brief. On the basis of the literature and personal experience, the usefulness of percutaneous cannulation of the femoral vein is maintained and its technical advantages, reasonable simplicity and practicability are recalled. Finally the use is proposed of a technique based on a new single needle capable of speedily resolving the problem of vascular access in acute patients.

Acute Kidney Injury↗

PubMed1976

Weekly artificial kidney: personal monitor with cartridge re-use.

Cartridge re-use is now successful in centre and home haemodialysis. The economic advantage of re-use is remarkable even in the case of a single re-use. However, hepatitis and pyrogenic reactions may follow re-use and are a source of possible contamination. The problem of storing sterilised cartridges also arises. In order to reduce the work load and simplify preparation and re-use the authors have developed a simple 'personal monitor' that permits automatic recovery of the cartridge and eliminates handling. In our unit this 'personal monitor' has been used for 14 months without complications and with considerable saving. By using the same cartridge three times for each patient, the aim of a 'weekly kidney' has been achieved.

Humans↗

PubMed1973