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Biomedical subjects

P Gerometta

Publications and source records attributed to P Gerometta.

24 records · Page 2Linked to original sources
PubMed1981

[Blunt and penetrating abdominal injuries].

During the last 10 years 0.45% of all our patients were operated on because of blunt (92) or penetrating (22) abdominal trauma. In the acute phase, diagnosis can be made on clinical symptoms alone. Of the early diagnostic procedures, peritoneal lavage is most reliable. Laparoscopy, ultrasonography, computed tomography, and arteriography are procedures used later, but only when the patient's circulation is stable. The most frequent injury encountered is splenic rupture, followed by rupture of the liver and gastrointestinal tract. When one single organ is injured, lethality is under 10% and grows to more than 30% when several organs are injured.

Abdominal Injuries↗
PubMed1981

Excitatory effect of converting enzyme inhibitors on efferent sympathetic postganglionic nerve activity to the kidney in the rat.

1. Experiments were designed to evaluate the effect of converting enzyme inhibitors on autonomic nervous system function in the rat. 2. Arterial blood pressure, heart rate, efferent postganglionic sympathetic activity and afferent nerve activity from the right renal nerves were recorded in anaesthetized, spontaneously breathing, non diuretic rats, either with an intact spinal cord or with a spinal cord transected at the T6 level, before, during and after intravenous injections of 0.5--1.0 mg/kg of teprotide or captopril. 3. After injection of drugs, efferent sympathetic nerve activity markedly increased and reached its peak value 4 min later, both in rats with an intact spinal cord (101 +/- 21% mean +/- SE, above the control discharge) and with a spinal cord transected at the T6 level (166 +/- 41%, above the control). 4. Afferent activity from the renal nerve, on the other hand, did not consistently change during converting enzyme blockade. 5. The results indicate that the efferent sympathetic excitation cannot be due either to a baroreceptor or to a renorenal reflex. This excitation might be responsible, at least in part, for the increase in renin secretion which follows the blockade of angiotensin-converting enzyme.

Adrenergic Fibers↗
PubMed1978

[Retroperitoneal injuries: introduction (author's transl)].

Injuries of the retroperitoneal organs occur mainly in patients with multiple traumas. Spine and spinal muscle provide an effective protection against blunt trauma from behind. In the front the thin peritoneal layer is just a biological border. Therefore injuries of the abdominal and retroperitoneal organs frequently occur together. Direct clinical examinations are limited by the specific anatomical situation; further invasive diagnostic procedures deal mainly with indirect effects of retroperitoneal injuries. Massive hemorrhage with consequent retroperitoneal hematoma is the dominant pathophysiologic course; mortality is high.

Abdominal Injuries↗
PubMed1976

[Intraoperating measuring of tissue oxygen pressure on the surface of the gastric mucosa. A new method for the control of complete vagotomy of the stomach].

A new method for the control of complete gastric vagotomy. Anew method is presented to control the completeness of gastric vagotomy. The procedure is based on measuring of gastric mucosa tissue oxygen pressure as an equivalent for the diminished perfusion of gastric mucosa after vagotomy. The results up to now proved the method reliable. Since we practice this method in quite a number of vagotomies primarily not severed vagal branches could be found and cut later.

Animals↗
PubMedDate not supplied

[Retrospective study of the efficacy of aprotinin in heart valve surgery in adults].

Aprotinin effects on postoperative bleeding, redo operations due to excessive bleeding and postoperative blood products use have been retrospectively evaluated on a population of 894 consecutive patients operated upon between 1987 and 1991 for valvular surgery. In this period, aprotinin has been routinely used following the "High Dose" protocol starting from January 1990. To analyse results, all the patients considered (Group I) were divided into subgroups, following the heart valve operated upon, in "mitral" patients (391 patients, 43.7%, Group II), "aortic" patients (375 patients, 41.9%, Group III) and "mitro-aortic" patients (128 patients, 14.3%, Group IV). Each of these Groups has been subsequently split depending on whether or not they received aprotinin (Subgroups IA, IIA, IIIA, IVA with aprotinin, subgroups IB, IIB, IIIB, IVB without aprotinin). Considering the whole population (Group I), aprotinin determined a significant reduction of post-operative bleeding (499 +/- 634 ml Group IA versus 713 +/- 572 Group IB, p = 0.000), redo operations for bleeding (15/410, 3.7% Group IA versus 45/484, 9.3% Group IB, p = 0.0000) and consequently the percentage of patients exposed to blood products transfusion (37/410, 9% Group IA versus 163/484, 54.3% Group IB p = 0.0000). When the other Groups (II, III and IV) were considered, aprotinin determined a significant reduction of postoperative bleeding and of donor blood transfusions, while redo operations for bleeding, although less in total number, were not significantly reduced. Moreover, aprotinin has been effective in reducing postoperative blood losses, redo-operation for bleeding and blood use independently of the kind of oxygenator used: bubble vs hollow fibers.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗