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Biomedical subjects

P Gehanno

Publications and source records attributed to P Gehanno.

At least 145 records · Page 8Linked to original sources
PubMed1980

[Medical treatment of laryngotracheal stenosis (author's transl)].

The authors review the various types of treatment involving drugs and physical agents used for the non-surgical therapy of laryngotracheal stenosis. They emphasize three interesting propositions: the use of zinc sulphate, of lathyrogens and muscle relaxants, an extensive experimental study of which would be worthwhile in the particular context of laryngotracheal stenosis.

Adrenal Cortex Hormones↗
PubMed1980

[Chondronecrosis of the cricoid after prolonged intubation (author's transl)].

On the basis of 4 cases of partial chondronecrosis of the cricoid after prolonged intubation, the authors review the literature which contains very few similar cases. With regard to pathogenesis, in the light of experimental studies and clinical findings, they emphasize the importance of two lesional factors: excessive diameter of the intubation tube and excessive deflection of the patients' head. All of these factors increase the pressure applied by the tube to the region inferior to the posterior commissure. These parameters would appear to be more important than the duration of intubation itself. The prognosis of these lesions is related to the extent of necrosis: poor when the latter involves the major part of the chaton, generally good when it is limited to partial lysis of the cartilage which may be associated with arytenoid sequestration. Calibration procedures were used in each case. It should be borne in mind that such methods are inadequate for the treatment of massive chondronecrosis which requires repeated operation.

Adult↗
PubMed1978

[The management of corrosive oesophagitis (author's transl)].

Regardless of the treatment used against corrosive oesophagitis, the laryngologist must play a role from the beginning and throughout the course. The fibroblasts and collagen fibres which results are the natural agents of healing but, at the same time, are responsible for virtually inexorable stenosis if the corrosion has passed through to the muscular layers. Infection is constant and contributes to stenosis. The effectiveness of antibiotics is certain. They must be used from the beginning and continued for as long as necessary. As far as fibroiss is concerned, dilatations remain the basic treatment, their application requiring great experience and much patience and tenacity. Replacement surgery is attractive. It comes up against the stenosing perioesophageal inflammatory process which tends to die down in time but remains active for a long period. The nENT specialist must therefore pay careful attention from the very end of the postoperative period onwards. The gravity of oesophageal burns justifies intensification of preventive measures. Since it impossible to complete eliminate corrosive oesophagitis, efforts must be directed towards the discovery of substances capable of inhibiting collagen synthesis. Corticosteroids used in the treatment of shock do not prevent stenosis. In the laboratory, B.A.P.N. has shown its effectiveness in the rat. Also in the rat, particularly difficult experiments are in progress using penicillinamine. Although such methods have as yet to be extended to human clinical use, there are nevertheless grounds for hope.

Adrenal Cortex Hormones↗
PubMed1978

[Preventive treatment in caustic stenosis of the oesophagus (author's transl)].

The authors review the varioux forms of treatment used experimentally and clinically in an attempt to prevent oesophageal stenosis following ingestion of caustic substances. Corticosteroid therapy is still used by certain authors though its effectiveness is far from obvious. However, promising results have been obtained experimentally using substances such as amino-nitriles, which alter the properties of newly formed collagen.

Adrenal Cortex Hormones↗
PubMed1975

[Nasopharyngeal fibroma. Significance of super-selective angiography and embolization].

The authors describe a case of naso-pharyngeal fibroma which they treated, in order to prevent per-operative haemorrhage, by means of embolisation of the arterial pedicles. The result was very satisfactory, the operation being practically bloodless. They stress the advantages of angiography for obtaining information about these tumours. And, thinking ahead on the subject of embolisation, they weigh up the risk of haemorrhage due to surgery (which remains considerable whatever methods have been used hitherto) against the possible risk of embolism which appears to be negligible if it is carried out by a radiologist who is expert in this method.

Adolescent↗
PubMed1975

[Pharyngeal constrictors and deglutition (apropos of 4 cases].

The authors describe four cases of deglutition disorders, even resulting in aphagia in two cases, in which the constrictor muscles of the pharynx were quite clearly entirely responsible. Electromanometry made diagnosis possibe for these patients and it is the only method capable of distinguishing crico-pharyngeal achalasis from paralysis of the constrictor muscles. The authors draw attention to the fundamental importance of this method of investigation in the pathology of deglutition. The propellent role of the constrictors, emphasized by some authors, rather than the upthrust of the tongues seems to be the borne theory out by these cases. Despite surgical ablation as recommended by most authors, or the spontaneous pathological disappearance of the crico-pharyngeal, the condition of the patients described was not improved; therefore it would seem wise, if a decision is taken to operate, not to make any promises to the patients about improvement of function insofar as aphagia is due to paralysis of the constrictors. Diagnosis, it should be remembered, can only be made after electromanometric investigation which is an essential preliminary to any therapeutic decision.

Adult↗