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Biomedical subjects

P Galley

Publications and source records attributed to P Galley.

32 records · Page 2Linked to original sources
PubMed1984

Therapeutic use of adenosine for terminating spontaneous paroxysmal supraventricular tachycardia.

Intravenous adenosine proved effective in eight out of ten episodes of acute spontaneous supraventricular tachycardia. AV node blockade induced by adenosine occurred 20 s after injection, and disappeared very quickly. Side-effects were transient and never serious. Therefore, it is thought that adenosine can be proposed safely for the short-term treatment of supraventricular tachycardia. Because of the different mechanisms of action, the specific side-effects observed after ATP administration are unlikely to be encountered.

Adenosine↗
PubMed1983

[Measurement of the intestinal clearance of alpha 1-antitrypsin and the exchangeable potassium pool in elderly patients treated with anthraquinone glycosides].

In order to check the long-term tolerance of a laxative treatment, the authors supervised during six months a group of 14 elderly people (12 women and 2 men) with a mean age of 81.3 years suffering from long-standing constipation without any organic cause. The laxative was given in a daily dosage corresponding to 20 mg of sennosides. Alpha 1-antitrypsin (alpha 1-AT) clearance and exchangeable potassium pool (PPE) were measured, at the beginning (T0), and at the end of the third (T3) and the sixth (T6) months of the study. No abnormal variation of intestinal protein loss (alpha 1-AT: T0, 6.74 +/- 3.16; T3, 2.96 +/- 1.35; T6, 4.15 +/- 1.45 ml/24 h; T0-T3; p less than 0.05, T0-T6, T3-T6: NS) and exchangeable potassium pool (PPE: T0, 19.54 +/- 2.55; T3, 20.29 +/- 3.46, T6, 23.56 +/- 4.92 mEq/kg; T0-T3, T0-T6, T3-T6: NS) was observed. In opposition to current views, all long-term laxative treatments do not necessarily induce significant intestinal protein and potassium losses.

Aged↗
PubMed1982

[Medium-stay for geriatric patients: a long-stay waiting room or an active rehabilitation unit?].

From May 1979 to April 1980, 223 patients were discharged from a "medium stay" unit (mean length of stay: 45 days) for geriatric patients in Bordeaux (France). The outcome at discharge was established from retrospective data, and the long-term outcome (18 months) through a letter sent to general practitioners (rate of response: 88,5% with, in some instances, a prompting phone-call). The mortality rates were 22,5% in hospitalized patients and 38% in survivors after discharge. When those hospitalized for social reasons only are excluded, 62,9% of the remaining patients returned to their former place of residence at discharge. Moreover, 83% were still living at the same place after 18 months (range: 12-24 months). Considering the patients' ages and the seriousness of their conditions, "medium stay", geriatric units seem efficient in helping to maintain the aged at home.

Aged↗
PubMed1981

Filterability and cerebro-vascular disease.

800 mg of pentoxifylline 400 was administered daily to two groups of elderly patients (average age 80 years) with the aim of increasing cerebral efficiency. Fifty patients (Group I) were treated for 30 days and of these, 25 patients (Group II) were treated for a further, 60 days. The programme included a battery of psychometric tests (Rey's R.P.M. Recit of Barbizet, coupled image tests, immediate memory test) two geriatric scales (Geriatric Rating Scale and Nosie 30) and study of the deformability of red cells. Results at the 30th and 90th day were compared with pre-experimental results: corrected filterability was increased (Group I and II, P less than 0.05), memory tests showed significant improvement (Group I and II, P less than 0.005), geriatric rating scale showed no modification. There was no correlation between changes in corrected filterability and improvement in psychometric tests.

Aged↗
PubMedDate not supplied

[Visual evoked potentials in elderly subjects (author's transl)].

Study of visual evoked potentials by contrast stimuli (VEPL) and by luminance stimuli (VEPC) in 28 subjects aged between 65 and 95 years (mean age: 81.8 years). Changes related to aging in regard to VEP involve: an increase of latencies of VEPL affecting the early components and an increase in the maximum amplitude of VEPL. The course of EP as age progresses introduces a difference in topographical organisation with a deterioration of responses in the left occipital regions and a change in potentials recorded at the vertex. Aging would appear to cause more marked inter-individual differences which could have clinical implications by making it possible to demonstrate individual differences in the biological processes of aging.

Aged↗
PubMedDate not supplied

Morphological study of the aging human peripheral nerve.

The superficial peroneal nerve from 46 elderly patients was studied by light and electron microscopy. Like most elderly people, these patients displayed evidence of varying degrees of peripheral nervous system dysfunction, but they were not suffering from any disease known to alter the peripheral nerve. A quantitative study showed that myelinated fiber loss predominated in the large diameter group. In the majority of cases, clusters of regenerating myelinated fibers were numerous. On the other hand, Wallerian-like degeneration aspects, segmental demyelination figures and axonal organelle accumulation were relatively rare. Unmyelinated fibers were also notably damaged in most cases. There was moderate reduplication of endoneurial vascular basement membrane.

Aged↗