Search PubMed⌕ Search

Biomedical subjects

P Galea

Publications and source records attributed to P Galea.

At least 37 records · Page 2Linked to original sources
PubMed1990

Normal growth and development in a child with Baller-Gerold syndrome (craniosynostosis and radial aplasia).

The cardinal features of the Baller-Gerold syndrome (MIM *21860) are craniosynostosis and radial aplasia. Only 12 cases have been published and these are roughly divisible into two groups: cases without any additional abnormalities and cases with a broad range of additional features. We describe a boy with craniosynostosis and radial aplasia alone and highlight genetic counselling difficulties presented by a sporadic case of this rare syndrome.

Abnormalities, Multiple↗
PubMed1989

Comparison of maximum aerobic power, maximum anaerobic power, and skinfold thickness of elite and nonelite junior wrestlers.

The purpose of this investigation was to identify physiologic differences between elite high school-age wrestlers and nonelite wrestlers of comparable age, weight, and training experience. Two groups of junior wrestler, elite (n = 18) and nonelite (n = 18) were measured for maximum aerobic power (treadmill run), maximum anaerobic power of the arms and legs (Wingate test), and skinfold thickness. On the average (+/- SE) elite juniors had a VO2max of 52.6 +/- 2.0 ml/kg.min-1, 376 +/- 20 W for arm power, and 540 +/- 25 W for leg power. The nonelite group had a VO2max of 51.5 +/- 1.4 ml/kg.min-1 and 331 +/- 22 W and 467 +/- 29 W for arm and leg power, respectively. Ttests were computed to identify differences between the groups. The results revealed significant differences in four skinfold thicknesses, absolute anaerobic leg power, and relative anaerobic power of arms and legs. It was concluded that relative maximum anaerobic power is distinctly greater in elite high school wrestlers than less successful peers. In light of the results, it may be of benefit for wrestlers of lower caliber to decrease body fat, increase fat-free weight, and increase total body power through training.

Adolescent↗
PubMed1988

Maternal narcotic abuse and the newborn.

In 50 infants born to women who continued to take heroin during all or part of their pregnancy the drug withdrawal symptoms were mild and were noted in 21 infants (42%). Only nine infants required treatment. Sudden infant death syndrome occurred in two infants at 4 and 6 months.

Adolescent↗
PubMed1988

Tuberculous meningitis in children: a review of 15 cases.

Tuberculosis meningitis (TBM) is the most serious form of infection with Mycobacterium tuberculosis. Between 1968 and 1986 15 children (five boys and 10 girls) were seen at the Royal Hospital for Sick Children, Glasgow, because of TBM. Fourteen children were Caucasian and one was Asian. The mean age at presentation was two years. None had been given BCG vaccination. In 12 children close contact with other cases of tuberculosis was reported. The signs and symptoms which helped in the diagnosis are discussed together with the initial CSF findings, results of mantoux testing and chest X-rays. Three children had unusual modes of presentation. All children were treated with chemotherapy though the drug combinations, route of administration and therapy varied from case to case. Steroids were used in nine children. Five children required neurosurgical intervention. Two children died and of the survivors six had serious sequelae. Five children made a complete recovery. The outcome of TBM depended on the duration of symptoms prior to the onset of therapy, on the neurological status reached at the time of diagnosis and the age of the child. The roles of chemotherapy, steroids and neurosurgery in the management of TBM are discussed. The need for routine BCG vaccination of all neonates is examined.

Antitubercular Agents↗
PubMed1987

Toxic shock syndrome (TSS) in children.

Toxic shock syndrome is uncommon in the prepubertal age group. Two children presented with pyrexia, macular erythroderma, vomiting, hypotension and rapid deterioration of consciousness. One child had severe neurological involvement. The diagnosis of toxic shock syndrome was established in both cases by the exclusion of other causes and by culturing staphylococcus aureus. We postulate that the neurological manifestations were caused by a direct neurotoxic action of the staphylococcal-produced toxin. Both children made a complete recovery.

Child↗
PubMed1985

Ocular complications in juvenile chronic arthritis (JCA).

Fifty-six children with JCA have attended the Rheumatology Clinic at the Royal Hospital for Sick Children, Glasgow, over the past five years. Eleven have monoarthritis, 21 pauciarthritis and 24 polyarthritis. Seven children with pauciarthritis and one with monoarthritis developed ocular complications. Of these six were girls. In six children the arthritis preceded the uveitis. In one child arthritis and uveitis presented at the same time and in another the uveitis preceded the arthritis by one year. All were treated with steroids (7 topically, 1 systemically) and topical mydriatic agents. After an initial response the uveitis persisted as a low-grade inflammation gradually leading to secondary complications and increasing loss of vision. Only two patients enjoy normal vision at present. The importance of routine slit-lamp microscopy in all children with JCA is stressed, especially in those with pauciarthritis and antinuclear antibodies.

Acute Disease↗
PubMed1981

Isoimmune neonatal thrombocytopenic purpura.

Ten cases of isoimmune neonatal thrombocytopenic purpura (4 pairs of siblings and 2 singletons) are described. The condition was diagnosed by excluding other causes of thrombocytopenia , and in 8 cases it was confirmed by detecting antiplatelet antibodies in the mother. Perhaps steroids should be given to affected infants as soon as the condition is diagnosed in order to stabilise the capillary membrane. Exchange transfusion, using platelet antigen-negative blood if available, helps to remove antibodies and should be followed by the infusion of antigen-negative platelets, easily obtained from the mother by platelet-phoresis. The use of random donor platelets (as in 3 of these cases) was ineffective because 98% of the population are platelet antigen-positive. Nine of the infants recovered completely. The exception was an infant who developed hydrocephalus, possibly as a result of intracranial haemorrhage.

Blood Platelets↗