Search PubMed⌕ Search

Biomedical subjects

P Galbenu

Publications and source records attributed to P Galbenu.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Diagnostic difficulties--salvage diagnostic thoracotomies].

The authors are presenting the difficulties of diagnosis, in clearing up the etiology in two cases, where the acceptance of the exploring thoracotomy, influenced the prognostic and permitted to settle up the diagnosis. We are passing through, at this occasion, also the indications of this kind of operation.

Biopsy↗
PubMedDate not supplied

[Thyroid tuberculosis--a clinical case].

We present the case of a 38-year-old male patient with tuberculosis of the thyroid; the diagnosis was established on histological examination after surgery.

Adult↗
PubMedDate not supplied

[Pulmonary tuberculosis and Kaposi syndrome in HIV positive patient].

The authors point out the case of a young woman with AIDS who presents at the same time the test HIV (+), the secondary caseoextensive bilateral pulmonary tuberculosis confirmed by the bacterial examination (bK(+) culture), the skin's and pulmonary histological manifestations of the Kaposi disease, clinically suspected, was confirmed only at the autopsy. Clinical manifestations began with skin's modifications, followed 2-3 months later by the diagnosis of a pulmonary tuberculosis, the demise decease 4-5 month after the appearance of the first skin's lesion.

Adult↗
PubMedDate not supplied

[Pulmonary benign lymphocytic angiitis and granulomatosis--a benign lymphoproliferative condition].

BLAG--benign lymphocytic angiitis and granulomatosis is a granulomatosis disease which histologically presents a dense infiltrate of lympnoid cells that disturbes the normal alveolar architecture. Faint granuloma formation occur within the lympnoid infiltrate. A 32 years female patient was admitted for dry cough, exertional dispnea, low fever during last 11 month. Histological diagnosis was BLAG. The treatment was a combination of cyclophosphamide and prednisone. Follow up information after 9 month of treatment show a generally favorable evolution (clinical and radiological).

Adult↗
PubMedDate not supplied

[Acute rhinopharyngitis, acute interstitial pneumonia and parieto-frontal brain abscess with H. influenzae type B].

The paper deals with a parietal frontal cerebral abscess caused by HITB biotype I in a girl aged 8 months. First a meningitis is suspected, then a tuberculous meningitis unsuccessfully treated with ampicillin, biseptol, respectively INH, rifampicin, pyrazinamide, prednisone, phenobarbital and chloramphenicol. The patient died through a central respiratory standstill on the 17th day of disease. The anatomopathological examinations revealed a giant parietal frontal cerebral abscess. H.influenzae, (serum type B, biotype I) resistant to ampicillin, chloramphenicol, Kanamycin, rifampicin and tetracycline but sensitive to erythromycin and neomycin was also found. A pharyngeal infection with HITB was presumably the origin of the abscess.

Acute Disease↗
PubMedDate not supplied

Histologic aspects in pleural diseases revealed by needle biopsy.

In 59 patients, 18 to 82 years old, with pleural exudates, a number of 78 needle biopsies were performed in view of establishing the etiologic diagnosis. The diagnosis was: pleural tuberculosis in 9 cases, acute or chronic non-tuberculous inflammation in 8 cases, postinfectious sequelae in 6 cases, secondary malignant neoplasia in 10 cases; 2 mesotheliomas, and in 24 cases the aspect was normal or the minimal alterations found were not conclusive. The proportion of confirmations was of 81% for tuberculosis and 37% for cancer. The method is recommended as being of particular value in establishing the etiologic diagnosis of pleural exudates.

Biopsy, Needle↗
PubMedDate not supplied

[Scintigraphic and electrocardiographic changes after ligation of the pulmonary artery, pulmonary veins and mixed ligation in dogs].

The authors have investigated in 6 dogs the disturbances of the perfusion determined by ligature of the main left pulmonary artery, of the pulmonary veins, and mixed ligatures. The scintigraphic method was used (consisting in intravenous injection of radionuclide-labelled ferric colloids, and detection with the Anger camera). In 12 dogs electrocardiographic modifications were also investigated, occuring at various intervals of time after the above-mentioned ligatures. With the aid of scintigraphy it was noted that pulmonary perfusion was abolished in the corresponding lung both immediately and at 24 hours following ligatures. With the aid of scintigraphy it was noted that pulmonary perfusion was abolished in the corresponding lung both immediately and at 24 hours following ligature of the vessels. The same aspects was noted in all three types of ligature. Consecutive infarctions were noted at necropsies. The electrocardiogram evidenced sings of coronary failure when all the pulmonary veins of one lung were ligatured, signs of ventricular and atrial overcharge in dogs with ligature of the pulmonary artery and mixed modifications, although less severe, in combined vascular ligatures. The more rapid evolution toward death of dogs with ligatures of the pulmonary veins could be explained by the coronary failure.

Animals↗
PubMedDate not supplied

Infection in vitro of the human pulmonary macrophage with Staphylococcus aureus (bacteriologic and ultrastructural observations).

Alveolar macrophages from exeresis fragments taken from patients operated for pulmonary cancer were infected in vitro with Staphylococcus aureus. Part of the investigation was carried out in the presence of an antibiotic (pyopen) introduced in the culture medium. Bacteriologic seeding from an extracellular medium and from lyzed cells showed a greater intracellular multiplication rate. In the presence of pyopen there was a decrease in the number of germs due to the inhibition of multiplication. Electron microscopy revealed reduced phagolysosomal fusion, aspects of bacterial multiplication and the coexistence of intact bacteria and bacteria presenting structural alterations. The results suggest the importance of cellular parasitism in the chronic evolution of infectious bronchopulmonary processes.

Adult↗
PubMedDate not supplied

Cellular immune response in atypical tuberculosis diagnosed by PCR in paraffin embedded material.

The aim was to evaluate the cellular immune response in atypical tuberculosis and granulomatous inflammation consistent with tuberculosis (TBC), negative histochemically for acid-fast bacilli and analysed by PCR for Mycobacterium tuberculosis (MT) detection in paraffin-embedded tissue. Thirty six samples of differently localized atypical tuberculous lesions and granulomatous tuberculoid lesions negative for acid fast bacilli and 4 positive cases on Ziehl-Nielsen stain were analysed by PCR for MT detection and were tested immunohistochemically (IHC) for the cellular immune response in the granulomas and perigranulomatous tissue. The samples selected were: 7 pulmonary and 33 extrapulmonary specimens, especially lymph nodes. Histologically, the atypical tuberculous lesions contained supurative necrosis, defective granulomas and cellular polymorphism. The epithelioid cells showed frequent mitoses. The immunoprofile of cells was polymorphous. L26 positive small lymphocytes were found in nodular lymphoid aggregates surrounding granulomas. A significantly increased number of positive UCHL1 cells were found in 33 out of the 40 analysed cases, with a larger percentage of CD4 positive T cells (81.8% of cases). CD44 was positive in multinucleated giant cells (17.5% of cases), epithelioid cells (60% of cases) and lymphocytes (30% of cases). CD68 was localized in multinucleated giant cells and epithelioid cells, in a 4%, respectively 62.5% of cases. The PCR was performed in all 40 cases; the tissue samples were heterogeneous (lung, lymph nodes, lever, nasopharynx, etc.) and needed a good quality extraction of DNA. Performing a control PCR for Beta Globin tested the extraction; a good result was obtained in 31 cases (77.5%); from these, 19 cases had amplification for IS 6110. The cellular immune response in the atypical tuberculous lesions was similar in cases with and without acid-fast bacilli, but positive for PCR. In the most cases with negative PCR reaction, it was due to a deficient fixation of the material. The T lymphocytes were numerous in all types of tuberculous granulomas, with the prominence of CD4 positive subtype. The immunoprofile of the epithelioid cells, positive for CD44 and CD68, presenting frequently mitoses suggests an activate state in a possible relationship to the T-cell-mediated immune response in tuberculosis.

Antigens, CD↗
PubMedDate not supplied

[A case of tumor-like pulmonary sarcoidosis].

We present the case of a female patient age 32, with no medical history, presenting with chest pain and asthenia. Chest X-ray and CT scan revealed multiple nodular shadows in both lungs, suggesting lung metastasis. Bronchoscopy and broncho-alveolar lavage didn't reveal any malignant cells. Clinical examination and lab examinations didn't find any primitive extra-pulmonary tumor. Open lung biopsy was performed, revealing sarcoidosis. Patient received oral steroids, with significant radiologic improvement after only 1 month.

Adult↗
PubMedDate not supplied

[Sequential approach in a case of tracheal hemangioma: segmental tracheal resection after Nd-YAG laser application].

Tracheal tumors of malignant or benign origin are very rare. The symptoms may mimic asthmatic crisis, dyspnea at rest or light efforts appear only when the tumor obstructs 60% of the tracheal diameter. We present the case of a 50 year old patient, ex-smoker with symptoms present 5 years before admittance with dyspnea and small hemoptysis. Diagnosis was based on bronchoscopic examination, CT scan and histological examination of the resection sample revealing a rare benign tracheal tumor: a hemangioma. The sequential treatment of the disease is presented: interventional endoscopy and surgical resection. The excellent postoperative evolution emphasized the diagnostic and therapeutic value of bronchoscopy as well as surgery in benign tracheal tumors.

Anastomosis, Surgical↗