[Apropos of 3 cases of colonic interposition for stenosing peptic esophagitis].
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Adolescent↗
Biomedical subjects
P Gaillard
Publications and source records attributed to P Gaillard.
[Value of the dexamethasone suppression test in a sample of sectorized patients].
Dexamethasone suppression test (D.S.T.) was performed on 124 heterogeneous patients. The sensitivity was 75% and the specificity was 73%. These data are discussed and suggest that the D.S.T. can be an useful aid in the diagnosis of depression.
Alcoholism↗
[Delusional thematic alternation and cyclothymia].
The authors discuss the case of a 36 year old woman who, for several years, has been delirious and who has shown signs of an affective disorder, alternatively suffering from hypomanic and depressive episodes. What is most interesting is that she expresses erotomaniac delusions while she is elated and persecutory delusions while she is depressed. The authors propose an psychopathological explanation for her disorder.
Adult↗
[Molecular lipophilicity potential (MLP) in drug design. Complementing theoretical tools with experimental results].
The Molecular Lipophilicity Potential (MLP) is a versatile tool in drug design whose present state and potential developments are reviewed here. The MLP offers a three-dimensional representation of lipophilicity as calculated from partition coefficients. The intermolecular recognition forces and intramolecular effects encoded in lipophilicity are presented, followed by the theoretical foundations and validation of the MLP. It is then demonstrated that the MLP allows for the first time to investigate the dependence of lipophilicity on conformation. As a matter of fact, the MLP combined with an exploration of the conformational space of a solute reveals its "chameleonic" behaviour, i.e. its capacity to adapt to the molecular environment. Other applications of the MLP are presented and illustrated, namely its integration into 3D-QSAR (Comparative Molecular Field Analysis, CoMFA) and its interest as a docking tool.
Chemical Phenomena↗