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Biomedical subjects

P Gabriele

Publications and source records attributed to P Gabriele.

81 records · Page 5Linked to original sources
PubMedDate not supplied

[Radiologic hyperthermia with microwaves and radio-frequencies. I. Presentation of a multifrequency system].

A computerized system with automatic treatment parameters control for radiological hyperthermia, called Sapic SVO3, is presented. The system has been planned and built by the "Sezione Avionica ed Equipaggiamenti" of the Aeritalia in cooperation with the Radiotherapy Department of the University of Turin. The device is supplied with a multifrequency generator system (915, 433, 2-30 MHz) connected with many kinds of applicators (microstrip antennas, high constant dielectric material loaded antennas, waveguide antennas), with a fiber optic system for temperature control and with a previsional thermometry system.

Computers↗
PubMedDate not supplied

[Radiologic hyperthermia with microwaves and radiofrequencies. II. Results in 57 neoplastic recurrences].

The authors present their results with hyperthermic treatment (alone or associated with radiation therapy) on 43 patients (with a total of 57 sites) treated from september 1983 to august 1985. All patients had recurrent lesion of pretreated malignant tumors. Among these there were brest adenocarcinomas, squamous cell carcinomas of head and neck, melanomas and soft tissues sarcomas. The clinical protocol was: hyperthermia alone (43 degrees-45 degrees C during 30 minutes) twice weekly (for a total of 8-10 treatments) or hyperthermia plus radiation therapy (4 Gy/fraction) for a total of 6-8 seances. In summary the response rate (CR + PR) was 80.4% (RT + HT 90% - HT alone 67.5%); the complete response rate was 24.5%.

Adult↗
PubMedDate not supplied

[Results of interstitial curietherapy and combined transcutaneous radiotherapy-curietherapy in 150 patients with carcinoma of the tongue and/or mouth floor].

The authors report their experience on the treatment of carcinoma of the oral tongue and floor of the mouth with interstitial brachytherapy, alone or in combination with external irradiation. One hundred and fifty patients were treated; among these, 116 with brachytherapy alone, 34 with combined treatment. The five years local control in those patients treated with brachytherapy alone was 72.5% in T1, 61.2% in T2 and 35% in T3; in those patients treated with external irradiation and brachytherapy the global five years control was 42.5%. The global five years survival was 64% in the patients treated with brachytherapy alone and 48% in the patients treated with combined therapy.

Adult↗
PubMedDate not supplied

[Long-term survival following chemotherapy for recurrent head and neck cancer: patient characteristics].

Eighty-one patients with recurrent squamous cell carcinoma of the head and neck (60 patients) or undifferentiated carcinoma of the nasopharyngeal type (21 patients) were treated with cisplatin (80-100 mg/m2iv d1) and 5-fluorouracil (750-1000 mg/m2Cl d1-5). In squamous cell carcinoma patients there were 7 complete responses (11.6%), 25 partial responses (41.7%), 20 stable disease situations (33.3%) and 8 progressions (13.3%). In nasopharyngeal carcinoma patients there were 6 complete responses (28.6%), 9 partial responses (42.8%), 3 stable disease situations (14.3%) and 3 progression (14.3%). There were 5/60 patients (8.3%) with disease-free survival > 18 months in the squamous cell carcinoma group and 2/21 (9%) in the nasopharyngeal carcinoma group. All long-term survival patients had the following characteristics: good performance status (0-1 ECOG scale), disease- free interval from the first treatment > 12 months, local non-bulky relapse (rT1-2). A re-irradiation with palliative doses (20-48 Gy) was conducted in 3/7 patients. This treatment may have improved the response to drugs with regard to length and quality.

Adult↗
PubMedDate not supplied

[Radiotherapy of non-neoplastic diseases: the situation in Piedmont].

The authors report the results of a census among the Piedmont region radiation therapy departments during the period 1980-1991 concerning non antineoplastic radiotherapy. Eight out of eleven centers respond to the questionnaire. During the period considered 36,480 patients were treated, with an annual mean of 4056; the number of treated patients varies from 1.2% to over 71.3% in the different centers when compared to the number of neoplastic patients. Arthrosis, osseous angioma, cheloides and verruca were the most treated diseases. Plesioroentgentherapy and roentgentherapy were normally employed; telecesium and telecobalt therapy were also used; only two centers used electron beams or brachytherapy. The doses of radiotherapy were not uniform; also patients' information and follow-up criteria were quite different in the various centers. The authors conclude with a guidelines for future radiotherapy in benign diseases.

Humans↗
PubMedDate not supplied

Combined modality therapy for laryngeal and hypopharyngeal cancer.

In recent years, the improvement in results in terms of survival in the treatment of laryngeal and hypopharyngeal cancer at the same stage has been rather poor. Therefore, oncologists have tried to improve the quality of life through a decrease in morbidity while not decreasing the treatment efficacy. In particular, the objective was to preserve with noninvasive procedures the anatomy and function of the larynx and hypopharynx while not affecting the possible cure. The refinement on diagnostic, surgical and anesthetic procedures, the potential of modern radiotherapy, the acquisition of new knowledge in medical oncology have allowed the planning of combined modality therapy protocols aimed at organ preservation in many patients. Concurrent radiation and chemotherapy in patients with locally advanced disease is a clinical problem still under study. Results of some phase I and III studies have shown the efficacy of radiochemotherapy, at times with a non negligible toxicity involving healthy tissues, but with a real effective improvement in survival and organ preservation in laryngeal and hypopharyngeal cancer.

Combined Modality Therapy↗