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P G Tarazov

Publications and source records attributed to P G Tarazov.

At least 19 recordsLinked to original sources
PubMed2005

[Radiopaque oil chemical arterial embolization in treatment of pancreatic cancer].

The article is dedicated to a new method of treatment of pancreatic cancer, developed by researchers of St. Petersburg Research Institute of Roentgenology and Radiotherapy. The method consists in slowing down blood flow in the tumor by means of selective embolization of its arteries using a mixture of the chemiotherapeutic agent gemcitabine (Gemzar) in the oily radio-paque medium Lipodol Ultrafluid. Upon entering microcirculatory vessels, the agent diffuses into pancreatic tissue. This tumor chemoinfiltration provides prolonged contact between tumor tissue and the chemoembolization agent, thus allowing strong antitumor effect without high systemic toxicity. Experimental studies on 12 dogs have proved that oil arterial chemoembolization with lipiodol does not cause morphological changes in the pancreas, and is only manifested by short and reversible hyperenzymemia.

Angiography↗
PubMed2005

[Combined radiotherapy and endovascular x-ray therapy for invasive cancer of the urinary bladder].

The data are presented on treatment of 131 patients with transitional cell carcinoma of the urinary bladder. Radiotherapy was received by 57, regional intraarterial chemotherapy (RIAT)--27. Radiotherapy was combined with RIAT and selective hyperglycemia (HG) in 18 cases. Local super high-frequency (SHF) hyperthermia was given additionally to another 29 patients. Radiotherapy alone was followed by primary clinical cure, a 9.6-months relapse-free period and 3-months survival (36.8%), mean survival time being 26 months. In the RIAT group, these indices were 29.6%, 10.8 mos, 51.9% and 36 mos, respectively. Combination of radiotherapy, RIAT and selective HG yielded significantly improved indices: complete response--44.4%, relapse-free period--13.6 mos, 3-year survival--66.7% and mean survival time--43 mos. After addition of SHF hyperthermia, complete response rose to 69.0%, relapse-free period--18.2 mos, 3-year survival--75.8% and mean survival time--61 mos. Joint use of radiotherapy, RIAT, HG and SHF hyperthermia caused more damage to tumor, stimulated complete response and increased 3-year survival and mean survival time.

Adult↗
PubMed2003

[Long-term results of local ethanol injection therapy in the treatment of hemangiomatosis of the liver].

During the period from 1989 till 1998 local ethanol injection therapy (LEIT) was used in treatment of 37 patients aged 39-78. The multiple focused form of hemangioma of the liver was observed in 15 (41%) patients, solitary in 20 (54%), the diffuse-focused in 2 (5%) patients. The distribution of the tumors according to the histological structure was as follows: cavernous hemangioma in 22 (60%) patients, capillary--in 2 (5%) patients, mixed in 13 (35%). Local injection therapy was the only method of treatment of 17 patients. In 13 patients this method gave insufficiently effective embolization of the hepatic artery, in 2 patients the injection therapy was combined with ligation of the hepatic artery and in 5 patients--with resection of the liver because of another tumor. The volume of a single use of ethanol varied from 6 to 60 ml. Long-term results were followed-up during 3-6 years. By the data of USI, CT, NMR in all the patients there were changes in the tumor typical of fibrosis. Positive results of the treatment such as a reduced size of hemangioma were noted in 27 patients (73.0%), pains disappeared in 10 out of 29 patients (35%) who had pain syndrome. A conclusion is made that local ethanol injection therapy with 96% ethyl alcohol is effective in treatment of hemangioma of the liver. It gives good long-term results including a combination with the endovascular treatment and resection of the liver.

Adult↗
PubMed2003

[Percutaneous needle biopsy in the diagnosis of pancreatic cancer].

The data on two procedures of ultrasound-guided fine-needle biopsy of pancreatic masses in 81 patients are presented (1999-2001): for cutting biopsy--64, and aspiration--and 17. Pancreatic cancer was identified in 41, non-epithelial tumor--3, metastasis to pancreas--2 and indurative pancreatitis--21. Complication were rare: hematoma formation after interstitial biopsy--1 (1.6%) and subcutaneous seeding--1 (5.9%) after aspiration biopsy. Sensitivity, specificity and accuracy for cutting biopsy were 96.7, 100 and 96.9%, respectively: aspiration--90.9, 90.9 and 88.3%, respectively. Ultrasound-guided transabdominal fine-needle biopsy of pancreas is a low-invasive and effective method of diagnostic verification. The cutting procedure was more effective than aspiration biopsy: also, it helped identify histological pattern of tumor and grade of malignancy. Patients with chronic indurative pancreatitis are to be followed up even when primary fine-needle biopsy results are negative.

Aged↗
PubMed2003

[Modern technologies of diagnosis and combined surgical treatment in liver tumors].

Modern technologies used at St. Petersburg Central Research Institute of Roentgenology and Radiotherapy of Russia's Ministry of Health in the diagnosis and treatment of malignant and benign liver cancers are surveyed in the paper. Apart from routine examinations, like ultrasound scanning, computer tomography, MRT, angiography, the below new technologies were widely used: multi-stratum spiral computer tomography, special MRT techniques and positron-emission tomography. The new methods enabled us to diagnose the tumor and its extension, to choose an optimal intervention technique, to make an objective assessment of the results and to correct the treatment strategy. Preoperative embolization of the portal-vein branches in the damaged hepatic lobe and postoperative adjuvant local chemotherapy of the hepatic artery and portal vein belong to the new combined surgical treatment scheme. The method of combined arterial-portal chemoembolization, used in unresectable malignant hepatic pathologies, extends the survival of patients by 3-5 times. Ferromagnetic embolization presupposes the administration of ferromagnetic, through the arterial bed or direct puncture, into the tumor with a subsequent SHF-current treatment which brings about a selective tumor hyperthermia without heating the normal hepatic parenchyma. Arterial embolization combined with local injection sclerotherapy in hemangiomas of the liver provides for a complete regeneration of benign tumors and can be regarded as a low-trauma alternative to liver resection. The use of new methods of diagnosis and treatment expands the possibilities of surgical care for patients with hepatic neoplasms and essentially improves the treatment results.

Angiography↗
PubMed2003

[Arterial oil chemoembolization: a new method of treatment for pancreatic cancer].

A novel method of intra-arterial oily chemoembolization of pancreatic tumor has been developed. It slowed down regional blood flow in tumor dramatically due to injection of gemcitabin-in-oil. As a result, a prolonged contact of tumor with the highly-concentrated chemotherapeutic drug along the microcirculatory bed was assured. Enhanced antitumor effect, unaccompanied by any increase in systemic toxicity, was obtained by intensifying gemcitabin perfusion in the tissue. Tumor vessels had to be contrast-enhanced during the selective angiography of great vessels feeding the pancreas. Diagnostic angiography was performed in 63 patients with locally advanced tumors (T4NxMo) in 1999-2002. A total of 98 intra-arterial oily chemoembolizations (1-11 per patient) were carried out in 32 (51%). One or two-year survival rates in these patients after hemzar were 50 and 15%, respectively. Arterial oily chemoembolization is a safe and potentially effective method for the treatment of pancreatic cancer.

Adult↗
PubMed2003

[Long-term regional chemotherapy for colorectal liver metastasis: significance of hepatic arterial anatomy in the surgical placement of the implantable infusion device].

The range and frequency of aberrant hepatic arterial anatomies and their significance for placement of implantable hepatic arterial infusion devices have been studied. The angiographs of 1439 patients treated at the Institute's Clinic (1985-2002) were used. The following 6 types of aberrant hepatic arterial anatomy were identified (J. Hiatt et al). Normal anatomy (type 1) was the most frequent (67.6%). The abnormal variants included: the aberrant left hepatic artery (LHA) running from the left gastric artery (LGA) (type 2)--9.9%; the aberrant right hepatic artery (RHA)--from the superior mesenteric artery (SMA) (type 3)--9.2%; the aberrant LHA from LGA with the aberrant RHA from SMA (type 4)--3.8%); the common hepatic artery running from SMA (type 5)--1.5%: other variants (type 6)--8.0%. Aberrant hepatic arterial anatomy occurred in every third patient. It was responsible for failed perfusion, frequent thrombosis of both hepatic arteries and infusion devices, suspension of regional chemotherapy and affecting its effectiveness. Proper identification of aberrant hepatic artery anatomy is vital for placement of implantable infusion systems.

Antineoplastic Agents↗
PubMed2003

[Preliminary results of selective combined therapy for patients with urinary bladder cancer].

The paper discusses the methods of complex treatment for invasive bladder cancer which includes radiation therapy, regional intraarterial chemotherapy with cisplatin drugs, selective hyperglycemia and local SHF-hyperthermia. Complete local response was reported in 18 (56%) out of 32 patients with stage II-IV tumors, partial--8 (25%), no response--6 (19%). The method appeared effective and safe; it offers good perspectives in bladder cancer treatment.

Adult↗
PubMed2002

[Combined hepatic-artery and portal-vein chemoembolization for colorectal cancer metastatic to the liver].

The purpose of the study was to evaluate the results of combined (hepatic artery and portal vein) oily chemoembolization (OCE) in patients with unresectable colorectal liver metastases. Courses of combined OCE were given to 45 patients (1990-2000). For arterial OCE (n = 150), 40-100 mg doxorubicin mixed with 10-15 ml iodized oil and gelatin sponge was used. OCE of the portal vein (n = 118) included injection of doxorubicin-in-oil without sponge. Response to treatment (partial tumor decrease or stabilization) was reported in 80%. Serious complications occurred in 3 patients (7%) but there was no mortality. The mean and median survival rates for those patients who died were 20.2 and 17 months, respectively. The 1-, 2-, and 3-year survival rates were 83, 40 and 14%, respectively. These results were significantly better than those for arterial OCE alone or hepatic arterial infusion. Combined (arterial and portal vein) OCE with doxorubicin appears the most effective locoregional treatment for unresectable colorectal liver metastases.

Adult↗
PubMed2002

[Role of interventional radiography in the treatment of the hepato-pancreato-duodenal area, complicated by obstructive jaundice].

We assessed the role of interventional radiological procedures used in the treatment of patients with hepatopancreatobiliary cancer complicated by obstructive jaundice. Between 1990 and 2000, 71 patients underwent percutaneous transhepatic biliary drainage (PTBD): external drainage--18 (group A); external-internal drainage or stenting (group B), and external-internal drainage or stenting plus chemoinfusion or chemoembolization of the hepatic artery--15 (group C). Mean survival (M(SD) calculated for patients who died was 2.1(0.5 mo for group A; (pb,c(0.01), 7.9(6.7 mo (group B), and 16.6(14.8 mo for group C (NS with B). The actual one-year survival was 10, 25, and 45%, respectively. External-internal PTBD and stenting are safe effective palliative procedures for patients with malignant obstructive jaundice. Survival in patients with hepatopancreatobiliary cancer doubled after chemoinfusion or chemoembolization, without grave complications or lethality.

Adult↗
PubMed2002

[Preoperative embolization of the portal vein in malignant tumors of the liver: preliminary results].

Preoperative embolization of the right portal vein and following hepatic resection were performed in seven patients with primary and secondary liver malignancies. The indication for the procedure was a small amount (30%) of the future remnant liver (FRL). The ultrasound-guided percutaneous transhepatic puncture of the portal vein and its embolization with gelatin sponge or silicon polymer was used. No complications of the procedure were noted. In 19-56 (mean 33) days computed or magnetic resonance tomography showed a significantly increased FRL volume (mean 40%). Right or extended right hepatectomy was performed in 5 and 2 patients respectively without lethal outcomes. A conclusion is made that the preoperative portal vein embolization is a safe and technically simple procedure that reduces the risk of postoperative hepatic failure after major liver resection.

Adult↗
PubMed2001

Oily chemoembolization of pancreatic head adenocarcinoma.

Oily chemoembolization is a known method of treatment for hepatic malignancies but was never used for pancreatic cancer. We report the case of a 48-year-old patient with unresectable adenocarcinoma of the pancreatic head treated by repeated chemoembolizations of the feeding (gastroduodenal) artery with gemcitabine-in-lipiodol. After 10 procedures there was a marked decrease in tumor. Radiologic examinations showed no signs of viable tumor. The patient is alive and symptom-free 22 months after the start of treatment. Oily chemoembolization should be investigated as a technically simple, safe, and potentially effective palliative management of unresectable pancreatic head carcinoma.

Adenocarcinoma↗