Biomedical subjects

P G Papathanasopoulos

Publications and source records attributed to P G Papathanasopoulos.

4 recordsLinked to original sources

PubMed1996

Spontaneous esophageal rupture in adult dermatomyositis.

Dermatomyositis is a chronic inflammatory myopathy with severe prognosis. A 57-year-old woman suffering from dermatomyositis is presented who, in the course of the disease, developed acute spontaneous esophageal rupture due to dermatomyositis involvement of the esophagus. She was successfully treated with total esophagectomy and stomach interposition. This is the first report of spontaneous rupture of esophagus in dermatomyositis.

Dermatomyositis↗

PubMed1994

Pattern reversal visual evoked potentials in retinitis pigmentosa.

Pattern reversal visual evoked potentials (PR-VEPs) of 31 patients with retinitis pigmentosa (RP) and 20 normal control subjects were recorded and compared. Recordings were taken from Oz referred to Fz, by stimulating with squares subtending 60 min, presented at a visual field of 30 degrees and 98% contrast. The mean latency of the main positive component P100 of the PR-VEP of the RP patients was 116.1 msec (SD 12.71) and 114.84 after stimulation of the left and right eye respectively. These values are significantly different (p < 0.001) from the equivalent values of the normal controls (102.5 ms (SD 5.1) and 100.6 ms (SD 4.6) for the left and right eye, respectively). Fourteen patients had a P100 latency more than 3 SDs from the normal mean value. Subsequently the patients were classified into three groups (for each eye separately) according to visual acuity (VA) and comparison for PR-VEP amplitude and latency was performed. In group A patients with VA 6/6, in B with 6/9 and in G with 6/12 or more were included. Decrease of VA was significantly associated with increased latency. The amplitude was not significantly affected except for group C. All 3 groups were not significantly different in age. The P100 in group A was consistently prolonged, compared to normals. It seems that RP can introduce significant increase in the PR-VEP latency associated with decreased VA. This may have diagnostic and prognostic implications.

Adolescent↗

PubMed1991

Sarcoidosis in a patient with myasthenia gravis. Case report and review of the literature.

The case of a 38-year-old white female, with a long history of myasthenia gravis, who developed sarcoidosis is presented. The diagnosis of myasthenia gravis had been established on the basis of typical clinical symptoms with severe myastenic crises necessitating respiratory support, characteristic electromyographic findings, positive anti-acetylcholine receptor antibodies and response to appropriate medications. After 9 years of disease and while in apparent remission, she presented with ankle arthritis and bilateral hilar adenopathy. A transbronchial lung biopsy showed noncaseating granuloma, typical of sarcoidosis. To our knowledge, the combination of myasthenia gravis and sarcoidosis is extremely rare and emphasizes the intriguing tendency of some immunologic disorders to appear together in certain individuals.

Adult↗

PubMed1991

A programmable digital video pattern generator controlled by microprocessor for basic research and clinical applications.

A programmable digital video pattern generator controlled by a microprocessor is described as a part of any commercial or specific visual evoked potential analysis system. The generator handles all kinds of patterns (uniform, orthogonal and radial) with all known presentation modes (onset, offset and reversal) and resolution 640 x 200 square pixels. The frame rate of the generator is adjusted to be compatible to either low cost 50 Hz video monitor or expensive ones of higher frame rate. The operation parameters defined by software are: pattern selection, trigger mode, field selection and stimulation rate. The development of software applications for special research demands is desirable because of the control of the generator by a microprocessor.

Computer Graphics↗