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Biomedical subjects

P G Moreau

Publications and source records attributed to P G Moreau.

At least 19 recordsLinked to original sources

Bipolar hip replacement in sickle cell disease.

A retrospective study is presented of 26 uncemented bipolar hip replacements for avascular necrosis of the femoral head due to sickle cell disease which were carried out between 1987 and 1992. All patients were treated according to a protocol. The average follow up was 4.6 years (range 2.1 to 7 years). After operation, the average Harris hip score improved from 36 to 88. Bone culture was positive for bacterial growth in 4 hips (coagulase negative staphylococcus in 3). There was progressive wear of acetabular articular cartilage in 2 cases, but no clinical or radiological evidence of loosening of the femoral stem. Seventeen complications occurred in 9 of the 21 patients (5 in one patient). A longitudinal split of the femur was the commonest operative complication and occurred in 5 hips. Femoral medullary sclerosis was seen in 8 cases. Patients with sickle cell disease have a high risk of complications, but this type of hip replacement should be considered in carefully selected patients who have avascular necrosis of the femoral head.

Adolescent

Solitary infantile myofibromatosis of axis. A case report.

Lytic lesions of the cervical spine are rare and may be caused by infection or tumors. The authors report a rare case of solitary infantile myofibromatosis presenting as a lytic lesion of the second cervical vertebral body (C2) and odontoid, causing atlanto-axial instability.

Adolescent

9 Knee arthroplasties for sickle cell disease.

Sickle cell disease sometimes presents with knee arthropathy secondary to osteonecrosis. We report our experience with 9 total knee arthroplasties in 5 patients. The joint fluid, synovium, capsule, and excised bones were sent for culture. Tissue cultures from 5 knees grew organisms. The outcome was: 6 excellent, 1 good, 1 satisfactory, and 1 poor. Infection in 1 case led to removal of the prosthesis and subsequent arthrodesis. 1 patient had persistent peroneal nerve palsy. There were no hematological complications. We suggest that osteonecrosis in sickle cell disease should be considered septic.

Adolescent

[Corneal complications caused by indomethacin eyedrop].

During ocular treatments by drops of INDOCID are observed 4 superficial punctuate keratitis disappearing when INDOCID is discontinued, and 2 diffuse corneal oedemas. Some possible explanations for such a corneal involvement are suggested.

Adult

[Syndrome of acute choriocapillaris ischemia in leukemia. Thoughts apropos of a case].

Choriocapillaris occlusion is rare in leukemia. After Zimmerman in 1964 our case is the tenth published. A 20-year-old maghrebin male with documented acute lymphoblastic leukemia in relapse from two years was evaluated for sudden loss of vision Examination of the both fundus revealed a serous central retinal detachment. Our material consists in four fluorescein angiographies realized at 72 hours, 8th, 25th and 65th days. Initial aspect was numerous hyperfluorescent spots at the level of the pigment epithelium and following a bleb of serous detachment fullfiled of dye. The deep leakages were blown out after a week, when patient received anti-neoplasic drugs and corticoids. On the 25th Elschnig's spots appeared but a recurrence happened after two months. Unfortunately the eyes were not documented. Choroid is the most frequent ocular structure infiltrated in leukemia. On the other hand parallel may be done with Stern and Ernest experimentation (microspheres occlusion). Thus we considered that occurs infraction of choriocapillaris units by lymphoblasts or coagulopathy. Succed focal acute changes in Bruch's membrane and pigment epithelium.

Acute Disease

[Cryosurgery].

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Cryosurgery