Biomedical subjects
Publications and source records attributed to P G John.
An automated immunosensor has been applied to the detection of Staphylococcus aureus enterotoxin B in cream. It was capable of detecting the toxin down to a level of 5 ng/g in approximately 10 min. This paper describes the immunosensor method used and how it compares with conventional ELISA (enzyme linked immunosorbent assay) methods.
Pulmonary hyalinizing granuloma (PHG) is a rare entity included in the differential diagnosis of pulmonary nodules of unknown origin. The pathologic entity may represent a peculiar form of pulmonary immune reaction. We report the case of a 40-year-old white woman who had nodular lesions in both lung bases after a 10-year history of multiple sclerosis. An open lung biopsy was required to make the diagnosis. The association of pulmonary hyalinizing granuloma with multiple sclerosis could be coincidental, but since there is a possibility of immune reaction in the pathogenesis of both diseases, the association may be significant.
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Neutropenia is an uncommon but potentially serious complication of drug therapy. Many drugs, especially antibiotics, can produce this untoward effect. Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more. The cause is believed to be either a hypersensitivity reaction or a toxic dose-related suppression of white blood cell precursors. Most patients improve after discontinuation of the drug.
In 1979, an isolated case of legionnaires' disease in a 46 year old Caucasian male Ohio physician was reported. Diagnosis was later confirmed by a fourfold increase in indirect immunofluorescent antibody titer level. Recovery began rapidly after the administration of erythromycin therapy and appeared to be complete. The following year the same patient suffered an apparent reinfection, once again realizing prompt and total recovery upon receiving erythromycin therapy. Although not commonly reported, the possibility of reinfection with the Legionella bacterium is a reality. The source of human innoculation need not necessarily be a common water supply or large cooling system reservoir (as was previously thought). Erythromycin continues to be widely regarded as the treatment of choice for infections with the Legionella bacterium even though this case demonstrates that it does not prevent reinfection.