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Biomedical subjects

P G Hepper

Publications and source records attributed to P G Hepper.

34 records · Page 2Linked to original sources
PubMed1992

Trisomy 18: behavioral and structural abnormalities. An ultrasonographic case study.

A behavioral and structural analysis using ultrasound of a fetus suffering from Edwards syndrome is described. A number of structural anomalies were observed: the classic hand deformity, extended legs, diamond-shaped head, open mouth and a severe cardiac abnormality. A number of distinctive behavior patterns were observed: vertical eye movements, longitudinal rotation of the trunk, rotation of hands, tremor of extremities and pulsatile body movements, which are not usually seen in the normal fetus. The use of behavioral indicators in the diagnosis of abnormalities is discussed. We conclude that the analysis of behavior may make a significant contribution to the ultrasonographic diagnosis of handicap.

Journal Article↗
PubMed1992

Embryonic olfactory learning in frogs.

We examined the effect of embryonic olfactory experiences on behaviour after hatching in two species of anuran amphibians, Rana temporaria and Rana sylvatica. Odorants (orange and citral) injected into the egg were "learned" by the embryo and subsequently preferred by tadpoles after hatching. The observed preferences were specific to the odours experienced prior to hatching, and tadpoles discriminated between the odour experienced as embryos and a novel odour. The acquired preference was maintained after metamorphosis for those individuals that exhibited a preference as tadpoles. Preferences of tadpoles were also influenced "naturally" by odours present in the water surrounding the developing embryos. The experimentally induced olfactory preferences did not appear to influence the exhibition of sibling recognition abilities. The study represents the first demonstration of "embryonic" learning in amphibians, and the functions and importance of early olfactory learning for amphibians are discussed.

Animals↗
PubMed1992

Habituation in normal and Down's syndrome fetuses.

The ability of ten normal and two Down's syndrome fetuses to habituate to a repeated auditory stimulus was assessed. The normal fetuses were assessed on two separate occasions during the final trimester of pregnancy. The number of trials to habituate and latency to respond were recorded. The results demonstrated that all normal fetuses exhibited a decrement in response to repeated presentations of the stimulus, a 250-Hz sine wave. This was the result of habituation and not fatigue since fetuses recovered responding upon presentation of a new (500 Hz) stimulus and habituated faster on re-presentation of the original stimulus. The performance of fetuses remained stable over the two testing periods. The response of the Down's syndrome fetuses was different to that of normal fetuses rarely overlapping indices of habituation exhibited by normal fetuses. The study concludes that habituation may be a powerful tool to examine the behavioural and sensory development of the fetus and may be of use in the antenatal assessment of the existence and severity of neural abnormality.

Arousal↗
PubMed1991

Handedness in the human fetus.

The developmental origins of behavioural asymmetries, in particular handedness, have aroused considerable interest and debate. Until now such behavioural asymmetries have only been reported after birth. Here we report the existence of handedness before birth, expressed in terms of thumb-sucking by the fetus. Ultrasound observations of fetuses from 15 weeks to term revealed a marked bias for sucking the thumb of the right hand. This preference appears to be maintained throughout pregnancy, is unrelated to fetal position in utero but correlates with head position preference in the supine newborn. The findings indicate that handedness is present prior to birth and the implications of this for the development of laterality are discussed.

Female↗
PubMed1991

Heart rate response of the rat fetus and neonate to a chemosensory stimulus.

Resting heart rate (HR) and HR responses of fetal and neonatal rats are described before and after intraoral infusion of isotonic saline or lemon solution. Stable measurements of resting HR were obtained for fetuses over the last three days of gestation (E19, E20, E21) and pups on the day of birth (P0) and four subsequent postnatal ages (P1, P3, P5, P7). Resting HR decreased significantly on P0 relative to the three prenatal ages and exhibited a linear increase thereafter. Variability in resting HR was pronounced on E21, decreased sharply after birth, and gradually increased through P7. Developmental changes in the HR response of fetuses and pups were evident following infusion of lemon. Fetal HR responses to lemon were characterized by bradycardia, which increased in magnitude through P1, diminished after P1, and eventually changed to tachycardia by P7. Both resting HR and HR responses to chemosensory stimulation point to the immediate perinatal period as a time of quantitative and qualitative change during sensory development.

Aging↗
PubMed1990

Diagnosing handicap using the behaviour of the fetus.

The study of fetal behaviour may have important implications for the prenatal diagnosis of handicap. Since behaviour reflects the integrity of the fetal neural system the examination of fetal behaviour enables neurological assessment of the fetus. This paper discusses present methods of assessing fetal well-being and their shortfalls and then considers current research using behaviour to identify the compromised fetus. Studies using both spontaneous and elicited fetal behaviour are discussed. The paper concludes that a greater understanding of fetal behaviour promises great advances in the antenatal detection of handicap or fetal compromise and may enable midwives to become more involved in the assessment of fetal well-being.

Embryonic and Fetal Development↗
PubMed1989

Foetal learning: implications for psychiatry?

While many of the ideas presented concerning foetal learning and their implications for psychiatry are at present speculative, I would remind people of the words of Carmichael (1954): "a study of adult behaviour without consideration of its origin before birth is as incomplete as . . . the study of adult anatomy without reference to the embryology of the structures considered." It is folly to overlook the foetal period!

Female↗
PubMed1988

The discrimination of human odour by the dog.

In reply to a suggestion made by Galton in 1875, the ability of dogs to discriminate between the odour of human twins was investigated. In a matching-to-sample simultaneous discrimination task, dogs were tested on their ability to discriminate odours from twins differing only in genetic relatedness or only in environmental factors, particularly diet, or from twins identical in both genetic relatedness and environmental factors. Dogs could discriminate between the odours from twins who differed only in environmental factors and between the odours of twins who differed only in genetic relatedness. However, they were unable to discriminate between odours produced by infant twins identical in both genetic relatedness and environmental factors. Thus twins may be discriminated by dogs as long as they differ in genetic relatedness or environmental factors. The possible source of discriminable odours is discussed and how the effects of genes and environment are mediated considered.

Animals↗
PubMed1987

Catecholamines and aggression in animals.

This paper assesses the evidence for the role of catecholamines in the aggressive behaviour of animals. The effects of manipulating dopamine and noradrenaline function, either alone or in combination, are considered with respect to two categories of aggression, predatory and affective. Affective aggression is further subdivided into shock-induced defensive fighting, isolation-induced aggression and irritable aggression. The results indicate that catecholamines may not have a specific role in aggressive behaviour. Rather, they may act more to excite or inhibit general behavioural systems, although certain treatments do have a specific influence on aggressive behaviour. The review also highlights certain problems concerning the psychopharmacology of aggression; different species may make varying responses to the same treatment, whilst treatments exerting a similar pharmacological action may result in diverse behavioural effects.

Aggression↗
PubMedDate not supplied

Developmental aspects of kin recognition.

The ability to recognise kin requires the individual to possess a variety of abilities. Individuals must produce a cue which indicates relatedness, they must process this cue to determine relatedness and then must act on this cue. Research has concentrated on the first and final stage of this process, i.e., the cues of kinship and kin correlated behaviour. Little attention has been paid to how individuals process cues to determine relatedness. This paper discusses how individuals 'recognise' kin, the exhibition of kin correlated behaviour and considers the role of the MHC in these processes. Two broad theories have emerged to explain how individuals recognise their kin: either a recognition gene(s) or some experiential mechanism. In mammals there is no evidence to suggest that recognition (the processing of the cue) is under genetic control but rather is the result of experience, learning about related individuals during development. Moreover studies on kin recognition in the domestic dog suggest that all kin are not recognised by the same process but different classes of kin, parents, siblings may well be recognised using different means. Studies of kin correlated behaviour suggest that the behaviour exhibited towards kin by Mongolian gerbils is mediated by the environment. Factors of environmental familiarity, sex and developmental age all affect the response of individuals to kin and non-kin. In these situations the ability to recognise kin does not change but the exhibition of kin correlated behaviour changes according to environmental conditions. These studies indicate that kin recognition may not be the 'unified' process previously thought and thus any explanations of the proximate and ultimate causation of kin recognition need to encompass this complexity. The question remains of whether the MHC is complex enough to do so.

Aging↗