[Critical considerations and anatomo-topographical and organogenetic observations on Hunter's canal in man].
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Humans↗
Biomedical subjects
P Fusaroli
Publications and source records attributed to P Fusaroli.
Severe acute gastritis associated with Helicobacter pylori infection.
We describe the case of a young female referred to our unit because of acute upper abdominal symptoms. Upper gastrointestinal endoscopy showed a gastric picture resembling lymphoma or acute non-steroidal anti-inflammatory drug gastropathy (deep, large and irregular ulcers), but the clinical history and the histological examination of gastric biopsies were consistent only with acute gastritis Helicobacter pylori-correlated. The patient was treated with omeprazole and antibiotics with complete recovery. As the patient's cat had suffered from an acute gastrointestinal distress two weeks earlier, a case of zoonosis was hypothesized and an upper gastrointestinal endoscopy was performed also on the cat. Unfortunately, we were not able to detect Helicobacter pylori in the cat gastric mucosa, but only urease-producing spiral microorganisms. Possible sources of infection and pathogenetic mechanisms of the severe gastritis are discussed.
Acute Disease↗
Cancer of the esophagus--endoscopic ultrasound: selection for cure.
Several treatment options are available to treat esophageal cancer. Ideally, treatment should be individualized, based on the projected treatment outcome for that individual. Accurate staging of the extent of the disease at the time of diagnosis offers the most rational attempt at stratifying patients into categories that can be used to affect treatment choices. Endoscopic ultrasonography (EUS) is the most accurate nonoperative technique for determining the depth of tumour infiltration and thus is accurate in predicting which patients will be able to undergo complete resection. EUS is also being used for tumour staging in order to guide treatment decisions in patients with esophageal cancer.
Combined Modality Therapy↗
[Experimental liver transplantation].
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Animals↗
The three-dimensional structure of interdigitating cells.
The in vivo three-dimensional architecture of lymph node and spleen interdigitating cells (IDCs) has been studied in mice by means of a computer reconstruction program and polystyrene models. Tissue fragments treated with an osmium-zinc iodide fixative solution, which gives a brilliant and quite specific impregnation of IDCs, were embedded in Epon and cut into 2 microns thick serial sections. The data was transferred into a "MOP-Videoplan 3D-cell reconstruction" software program and both tridimensional plottings and morphometric measurements were obtained. Then polystyrene models were assembled. Our findings show a cell population of high spatial complexity. IDCs are large cells whose numerous cytoplasmic processes form an extensive three-dimensional network which envelopes lymphoid cells. The most characteristic feature of IDC' architecture is the large, flattened, sheet-like processes which expand for several microns from the cell body, embracing numerous lymphocytes and lymphoblasts. In certain cases surface invaginations create channel-like structures which cross through the IDC peripheral cytoplasm. The impressive extension of the IDC membranous network provides a powerful anatomic strategy which facilitates the interaction between IDCs and T-lymphocytes and creates a unique microenvironment for T-cell activation and proliferation. This study gives new morphological evidence for the strict physical interaction between IDCs and T-lymphocytes and supports the concept that IDC-T lymphocyte aggregation represents a very special microanatomical and functional unit.
Animals↗
Changes in biliary lipid secretion and cholic acid kinetics induced by diet, diet plus simvastatin and diet plus ursodeoxycholic acid in obese subjects.
The aim of this work was to evaluate and compare the effects of a low calorie diet (1026 kcal), simvastatin and ursodeoxycholic acid administration on biliary lipid secretion and cholic acid kinetics in dieting obese subjects. We studied 6 obese subjects before and after four weeks of a hypocaloric diet alone, after four weeks of diet plus ursodeoxycholic acid (900 mg/day) and after four weeks of diet plus simvastatin (40 mg/day), according to a Latin square design. The cholesterol saturation index was increased after diet alone, significantly reduced with diet plus ursodeoxycholic acid (p < 0.01), and unchanged during simvastatin administration. While the cholesterol output was reduced by all three regimens, diet plus ursodeoxycholic acid caused a significantly greater decrease than diet alone (p < 0.01). Cholic acid synthesis and bile acid secretion were decreased by diet and diet plus simvastatin (p < 0.05), but neither was affected by ursodeoxycholic acid. For cholic acid, all three treatments, but especially diet alone and diet plus simvastatin (p < 0.05), reduced the pool size; all three regimens also increased the turnover rate, but this was significant only for ursodeoxycholic acid (p < 0.01). Our study shows that, in obese patients, a hypocaloric diet reduces cholesterol-holding biliary lipid output and consequently increases the cholesterol saturation index. The addition of simvastatin to a hypocaloric dietary regimen reduces cholesterol secretion, but without variation in bile acid and phospholipid output thus the cholesterol saturation index remains unchanged. When ursodeoxycholic acid is added to the dietary regimen, it reduces cholesterol secretion, while maintaining bile acid output and, thus, lowers the cholesterol saturation index. Unlike simvastatin, ursodeoxycholic acid prevents the drop in cholic acid synthesis induced by a low calorie diet.
Adult↗