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Biomedical subjects

P Fucci

Publications and source records attributed to P Fucci.

5 recordsLinked to original sources
PubMed1996

Marked decrease of plasma neuroactive steroids during alcohol withdrawal.

The neuroactive steroids allopregnanolone (ALLO) and allotet-rahydrodeoxycorticosterone (THDOC) are the most potent endogens positive modulators of gamma-aminobutyric acid (GABA) on GABAA receptors, a receptor system presumably responsible for some behavioral responses to alcohol withdrawal. In a group of nine alcoholic subjects, the levels of plasma ALLO and THDOC were markedly lower than those of control subjects during the early withdrawal phase (day 4 and 5), when anxiety and depression scores were higher. In contrast ALLO and THDOC plasma levels did not differ from those of control subjects during the late withdrawal phase when anxiety and depression scores were low. These results suggest that the decrease of neuroactive steroid biosynthesis may contribute to the withdrawal symptoms.

Adult↗
PubMedDate not supplied

[Reflexions on the aspects characterizing the new INAIL tables regarding occupational diseases].

The AA examine the new Tables for occupational diseases in industry and agriculture, which have recently approved with the Presidential Decree n.336, april 13, 1994. The main innovations are analysed, like the elimination of some too generic terms, which had often allowed contrasting interpretations and a non univocal jurisprudence. Other innovative aspects regard the new acquisitions of occupational medicine and strengthen, in the new formulation, the principles of the presumption of law in establishing a relation of cause and effect.

Deafness↗
PubMedDate not supplied

[D.lgsl. 625/1994--Protection against carcinogenic agents: the obligation to educate].

According to act 626/1994, employers have the duty to inform and train workers and their representatives. The implementation of training activities requires the following points: planning the training program according to the needs of the target population, use of the methods aimed at promoting learning and the adoption of safe behaviour, setting-up of evaluation tools. The disciplines of risk perception and communication and adult training may provide useful contribution in this frame. At the light of the preliminary experiences in this field, the importance of the following items for workers, workers representatives and employers is emphasized: probabilistic causality models, role of cognitive and emotional factors in the learning process, definition of carcinogenic according to national and international organisation, meaning of TLV with respect to carcinogenic exposure, interaction between carcinogens in the case of multiple exposition, risk evaluation, preventive measures, transfer of carcinogen risk from workplace to domestic environment, due to lack of compliance with basic hygienic rules such proper use of work clothes.

Adult↗
PubMedDate not supplied

[Safety assurance for occupational tumors in agriculture].

Cancer risk in farming is characterized by:-multiple exposure varying in time, space and between crops;-poor knowledge of agrochemical used by workers;-interset of both sellers and users mainly or acute toxicity of pesticides;-availibility of sufficient evidence of carcinogenicity in humans only for arsenical insecticides and for benzene used as solvent. The frequency of both claims for compensation and recognized cased is extremely low. Referral to exper agronomists operations in the area of interest can turn out to be of great value in assessing exposures. In case of exposure to carcinogenic agents defined as possible or probable, the following criteria may be adopted:-duration of exposure and latency time in agreement with findings from scientific literature;-biological plausibility of the association of interest;-evaluation of the interaction in the frame of multiple exposure, with special reference to the role of brief and/or low exposures. The above mentioned items are discussed by examining practical cases.

Agricultural Workers' Diseases↗