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Biomedical subjects

P Frey

Publications and source records attributed to P Frey.

At least 109 records · Page 6Linked to original sources
PubMed1976

[Sporadic adult hypophosphatemic vitamin D resistant osteomalacia (phosphate diabetes) and hyperparathyroidism].

Report on a patient with osteomalacia due to renal phosphate loss. At onset the patient was aged 43 years. No other tubular defects were detected except glycinuria. The patient was followed over a period of 12 years. 3 years after treatment with oral phosphate and vitamin D3 persistent hypercalcemia developed with highly elevated levels of parathyroid hormone. After removal of one enlarged parathyroid gland serum calcium normalized, but elevated parathyroid hormone levels still persist. The spontaneous occurrence of hypophosphatemic osteomalacia in an adult male and its connections with the development of hyperparathyroidism are discussed.

Adult↗
PubMed1976

[Organization of mobile intensive care in Zurich].

A mobile intensive care unit (Kardiomobil) has been in operation in the Zurich area (600 000 inhabitants) since March 27, 1972. This unit is staffed by a doctor and a nurse experienced in coronary and intensive care and two ambulance drivers. Although primarily designed for pre-hospital coronary care, it is equipped and operated as a "mobile intensive care unit".

Arrhythmias, Cardiac↗
PubMed1976

[Experiences with a mobile intensive care station (Kardiomobil) after 1 year's test operation in Zurich].

The Zurich mobile intensive care unit (Kardiomobil) admitted 502 patients in the first year of operation. 191 patients with confirmed acute myocardial infarction were seen. The Kardiomobil proved a success in shortening the total median delay between onset of symptoms and coronary care by 50%. Ten patients resuscitated outside the hospital were eventually discharged from hospital. 240 episodes of arrhythmia were observed in 182 of the 502 patients. 98 arrhythmias were successfully treated in this group, the best results being obtained in ventricular arrhythmias: 16 out of 26 patients with ventricular fibrillation were successfully defibrillated (61%), while 47 out of 53 episodes (89%) of frequent premature ventricular beats and all 9 episodes of ventricular tachycardia were corrected with lidocain and procainamid.

Arrhythmias, Cardiac↗
PubMed1976

[Reanimation outside the hospital by the mobile intensive care station in Zurich].

Of 502 patients handled by a mobile intensive care unit, 70 were resuscitated: 20 immediately, 9 within 3 min and 41 later than 3 min from onset of cardiac or respiratory arrest. There were 9 temporary and 10 longterm survivors among the 29 patients who underwent resuscitative measures within 3 min of collapse. First-aid training programs in resuscitation methods are a necessary supportive measure to the operation of mobile intensive care units.

Coronary Care Units↗
PubMed1976

The Mallory-Weiss-syndrome: a clinical study of 20 cases.

This is an account of 20 cases of MWS, representing 8% of a series of 247 consecutive upper GI-bleedings. Men above 40 years and persons with severe concomitant disease are specially at risk. The prognosis is rather good, mortality from bleeding being 10%. Surgery should not be undertaken unless all conservative measures, including vasopressin infusion and even Sengstaken-Blakemore tube have been applied. The typical history, a hiatal hernia and alcohol intake are frequently missing. Neither studies of gastric acid secretion nor esophageal manometry disclosed new pathogenic aspects.

Adult↗
PubMed1975

[Clinical aspects of carcinoma of the liver (author's transl)].

The incidence of epi-cirrhotic liver carcinoma is apparently on the increase. Between 1969 and 1973 there were 84 cases of primary liver carcinoma and 467 of cirrhosis among 10211 autopsies. In 74 (16%) the carcinoma had developed in a cirrhotic liver. Clincally the diagnosis of carcinoma had been made in only 14 cases. The mean survival time after the diagnosis was seven weeks, after onset of the terminal symptoms 13 weeks. Typical clinical features were decompensated, hypertrophic, often coarsely granular, liver cirrhosis. The best diagnostic method was apparently laproscopy and determination of alpha 1-fetoprotein and cholestatic enzymes.

Adult↗
PubMed1975

[Familial Wilson's disease: copper induced hemolysis, hypersplenism and hyperpigmentation as the main symptoms].

Wilson's disease was diagnosed in a 16-year-old adolescent who presented with signs of hypersplenism due to cirrhosis, with marked hyperpigmentation of both lower legs and neurological disturbances. In view of progressive thrombocytopenia and leukocytopenia, splenectomy was performed during therapy with penicillamine later in the course, and the result was good. The patient's 12-year-old sister was found to have a hepatic form of Wilson's disease with typical biochemical findings. During the initial hospitalization a severe, spontaneous copper-induced hemolysis was noted. Another sister probably has a presymptomatic form of the disease. The parents are healthy but heterozygote carriers with regard to biochemical findings. The importance is stressed of hypersplenism, hyperpigmentation of the legs and especially of acute hemolysis in infancy as pointers in the diagnosis of Wilson's disease. Further diagnostic and therapeutic aspects are discussed.

Adolescent↗
PubMed1975

[Effect of ethrane on the circulatory parameters of geriatric patients (author's transl)].

The cardiovascular effects of enflurane in geriatric patients have been compared with the effects of this anaesthetic agent in a group of young patients. The degree of cardiovascular depression in geriatric patients was much greater than in the young patients despite the smaller inspired concentration of enflurane necessary to produce a similar depth of anaesthesia. In comparison with halothane and neuroleptanaesthesia, enflurane produced the greatest decrease in cardiac output. The mean arterial pressure, however, was quite well maintained due to a simultaneous increase in total peripheral resistance.

Adult↗