Biomedical subjects
Publications and source records attributed to P Ficarra.
Reversed phase high-performance liquid chromatography was applied for qualitative and quantitative analysis of secoiridoid oleuropein and some flavonoids in leaf and bud extracts of Olea europaea L. The RP-HPLC procedure is rapid and reproducible. The results of quantitative analysis, correlated with pharmacological activity, are reported here.
High-performance liquid chromatographic (HPLC) and diffuse infrared reflectance spectroscopic techniques for qualitative and quantitative analysis of naturally occurring phenolic compounds in Crataegus oxyacantha L. have been applied. (+)-Catechin, (-)-epicatechin and a phenolic acid, the caffeic acid, were investigated in various extractives of Crataegus oxyacantha L. The reversed-phase chromatographic separation was achieved by a combination of isocratic and gradient elution.
RP-HPLC has been used for qualitative and quantitative analysis of some flavonoids in flowers, leaves and bud extracts of Crataegus oxyacantha L. Peak identification was obtained by comparison with retention times of pure standard substances and by UV analysis. Luteolin, luteolin-3', 7-diglucoside, apigenin, apigenin-7-O-glucoside and rutin have been identified and determined.
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In Langendorff preparations of rat heart, hyperkinetic ventricular arrhythmias (HVA) have been induced by an ischaemic perfusion (coronary flux 0.5 ml/min; pressure 8 mmHg) and following reperfusion at basal conditions (coronary flux 8 ml/min; pressure 50 mmHg). Crude methanolic extracts of Harpagophytum procumbens secondary roots and harpagoside showed a significant, dose-dependent, protective action toward HVA induced by reperfusion.
Effects of the crude methanolic extract of Harpagophytum procumbens secondary roots and two of its active principles, harpagoside and harpagide, on some smooth muscle in vitro have been studied. The results obtained show how the action of H. procumbens is due to a complex interaction between the various active principles contained in the drug and suggest that they, especially harpagoside, interfere with the mechanisms that regulate the influx of calcium in the cells.
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