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Biomedical subjects

P Ferrari

Publications and source records attributed to P Ferrari.

At least 415 records · Page 23Linked to original sources
PubMed1976

Effect of amantadine on drug-induced parkisonism: relationship between plasma levels and effect.

Amantadine, administered at a dose of 200 mg/day, antagonized the extapyramidal symptomatology induced by neuroleptic drugs in fifteen psychiatric patients. Steady-state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half-lives varied from 10-28.5 h with an apparent VD of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.

Adult↗
PubMed1976

Experimental evaluation in man of analgesic effects.

A device operated by compression has been studied in order to define a method of measuring analgesic effects. Three analgesics (metamizol, acetylsalicylic acid and ketobemidone) and placebo have been tested in man to verify the adequacy of this apparatus and its sensitivity.

Adult↗
PubMed1975

Urinary excretion of amantadine by the elderly.

The urinary excretion of single or multiple oral doses of amantadine hydrochloride by three elderly patients has been studied by gas chromatography. Steady state amounts in urine were about 230-240 mg per day. The half life of urinary excretion was approximately 34.17 hours. Urine collection from aged subjects is difficult.

Aged↗