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Biomedical subjects

P Fehlow

Publications and source records attributed to P Fehlow.

At least 19 recordsLinked to original sources
PubMed1995

[An increased incidence of megacolon in psychiatric and neurologic patients].

The incidence of megacolon is elevated in neuropsychiatric patients. Siegmund was the first, in 1935, to report on the development of megacolon and megasigmoid as the result of chronic atropine therapy of patients with postencephalitic parkinsonism and the associated risk of stercoraceous ulcers and ileus or even sudden death. The etiology of increased frequency of megacolon among neuropsychiatric patients is assumed to be nonuniform, and to include organic defects of centers of the autonomous nervous system in the diencephalon and/or hypothalamous, pharmacodynamic, psychogenic and neurogenic influences on the autonomic nervous system, akinesia and increased obstipation among psychiatric patients, insufficient pressure in the abdominal wall especially in the mentally retarded, with frequently associated weakness of the connective tissue. In cases of long-term therapy with psychotropic drugs the anticholinergic side effects with the risk of megacolon and resulting ileus, sometimes with fatal outcome should be borne into mind.

Cholinergic Antagonists↗
PubMed1993

Craniosynostosis as a risk factor.

Craniosynostosis is a little known organic factor in sociopathy. This factor should be among those taken into consideration in selecting patients to undergo craniotomy. Among 22,000 skulls of neuropsychiatric patients, there were 100 with premature coronal synostosis, compared with 57 with dolichocephaly. Thirty-seven of the 100 patients with coronal synostosis exhibited disorders of social adaptation; frontal cortex functions are assumed to be involved. There were 34 cases of mental deficiency, 21 cases of psychosis, 13 of cerebral vascular disease, 10 cases of epilepsy, 4 of acrocephalosyndactyly, 3 of decompensation by slight craniocerebral trauma, and 1 case of ependymoma of the IV ventricle. Dolichocephalic patients exhibited a stronger tendency towards depressive states and cerebral vascular disease. The risks of cosmetic impairment and resulting psychosocial problems are discussed; especially in girls with oxy- and scaphocephaly craniofacial correction, is indicated, as it is also in patients with Saethre-Chotzen syndrome. In cases of premature synostosis of the coronal suture or synostosis of several sutures for carrying out a craniotomy, it is advisable to employ a combination of orbito-frontosphenoidal osteotomy for extension of the anterior cranial fossa. Craniosynostosis is a risk factor which, depending on the individual case and the sex and age of the patient, can impair central nervous functions, social adaption, and the blood supply of the brain.

Adolescent↗
PubMed1993

[Aarskog syndrome in association with mental and psychological retardation, grand mal epilepsy and tardive dyskinesia and apparent radicular paralysis of the fibular nerve in torsion scoliosis].

The case of an about 22-year-old patient with AARSKOG-syndrome is reported whose scoliosis caused a radicular impairment with resulting severe paresis of the right fibular nerve. The syndrome was also associated with moderate mental retardation, epilepsy, premature craniosynostosis and tardive dyskinesias after neuroleptic therapy because of disorders of behaviour. The risks of idiopathic scoliosis in patients with dysmorphia-retardation syndromes should be taken into consideration and such children should be supervised by an orthopaedist.

Abnormalities, Multiple↗
PubMed1993

[Early infantile autism and excessive aerophagy with symptomatic megacolon and ileus in a case of Ehlers-Danlos syndrome].

A case of Ehlers-Danlos syndrome is reported, which was associated with mental retardation and early infantile autism. The patient died at the age of 19 by ectasy of the stomach as the result of extreme aerophagy causing a megacolon and by compression so finally resulting in a mechanical ileus. Investigation of the cerebellum revealed a significant rarefication and diminuation of the Purkinjè cells as well as the cells of the stratum granulare in the lobuli VI and VII, obviously due to a genetically determined malformation.

Adolescent↗
PubMed1992

[Neuropsychiatric manifestations of Saethre-Chotzen syndrome].

Four psychiatric patients with SCS are described. All exhibited essential tremor, minimal cerebral dysfunctions, speech disorders, bradyphrenia, disorders of personality with psychasthenie and suspicious traits, restrictions, increased irritability and depressivity, one case of mutism due to abnormal reaction and one of alcohol hallucinosis. The possibility of cosmetic handicap caused by craniofacial dysplasia should be taken into mind and perhaps surgically corrected. Because the craniofacial dysplasia is mostly moderate and the syndactylies are slight the SCS remains often unrecognized, but apart from psychic maldevelopment it is significant as the result of frequent association with other malformations.

Acrocephalosyndactylia↗
PubMed1992

[Significance of EEG findings in craniosynostosis].

Literature of the topic is reviewed and own findings of 80 patients with turricephaly and 38 with dolichocephaly are exhibited. Striking was the increased frequency of spike potentials, 8,8 resp. 16% (SW 5%). Genetical connection between causes of premature synostosis and increased associated epilepsy resp. spike potentials is supposed. In cases of craniosynostosis associated with epileptic fits the EEG remains further irreplaceable, moreover it is useful in the assessment of cerebral functioning prior to surgical intervention.

Cerebral Cortex↗
PubMed1991

[Encephalomyocarditis syndrome].

From 28 autopsy-cases with EMC, among them 10 with an age from 7 days to 16 years, had been none diagnosed clinically before. Typically we found an interstitial myocarditis and perivenous encephalitis with a preferred participation of the brain stem. Central failure was dominating cause of death. There were only 5 cases (3 adults) with meningitis. Myelitis was not found. Former cardiac, less often cerebral lesions are likely risks for the lethal event.

Adolescent↗
PubMed1991

[Symptoms of tic in childhood].

Literature at the tic phenomen of the last 100 years is reviewed. Phenomenology, incidence, etiology, differential diagnosis and therapy are exhibited.

Child↗
PubMed1991

[Primary hypogonadism associated with neuropsychiatric disorders].

Among 43 female patients aged 17-46 years, most with severe oligophrenia, there were 4 with primary hypogonadism (olfactory-genital dysplasia, Smith-Lemli-Opitz syndrome and lastly a Kanner syndrome). The incidence of genital underdevelopment is assumed to be higher among mentally retarded female patients. In cases of hypogonadism and hypogenitalism a search should always be made for possible mental and neurological disorders.

Abnormalities, Multiple↗
PubMed1991

[Forensic importance of premature craniosynostosis].

In agreement with Canabis craniosynostosis as a little known organic partial factor of sociopathy is demonstrated. A psychic syndrome of the frontal lobe with increased susceptibility in environmental damages is assumed to be basic disorder. In the criminals of the material sexual offenders were preponderating. Associated craniofacial dysplasias are a risk for psychic maldevelopment. The importance of premature craniosynostocis as a biological risk factor, incidence, diagnostic, indication for an operation, also in the meaning of a neurosurgical "Konflikttherapie" (cosmetical indication) are discussed.

Adolescent↗
PubMed1991

[Significance of electroencephalography in the physical examination of children with encopresis].

At an one time transversal examination 28 of 36 children with encopresis exhibited abnormal findings, increased incidence of sharp waves, a back ground that was too slow for their age and subcortical dysfunctions was striking. The abnormalities are approached as constitutional risks and maturational retardation with increased environmental propensity. Increased frequency of enuresis and encopresis in premature craniosynostosis was found. Electroencephalography should be used in paediatric and child psychiatric examination as a not burdening screening method for clarifying the aetiologic conditions of encopresis and getting hints of brain maturation, constitutional disorders and may be signs of brain damage.

Adolescent↗
PubMed1991

[Hirschsprung-Galant infantilism].

Report about a 17 1/2 year-old girl with severe mental retardation, dwarfism, hypogenitalism and short segment type of HIRSCHSPRUNG's disease, abortive SMITH-LEMLI-OPITZ syndrome is supposed. Literature about etiology and genetics of HIRSCHSPRUNG's disease is reviewed.

Abnormalities, Multiple↗
PubMed1990

[Dolicocephaly and premature synostosis of the sagittal suture].

Guided by the literature historical, racial, genetical and diagnostical aspects, likewise associated syndromes and malformations of dolichocephaly and premature sagittal synostosis are represented, also own clinical, roentgenological, pneum- and electroencephalographic findings of 57 patients. Vascular disturbances of brain were striking, further emotional lability and tendency for relapsing depressions. Psychosocial problems of patients with scaphocephaly are discussed in detail and from that a conditional indication for cosmetic correction is asserted.

Cephalometry↗
PubMed1990

[Significance of EEG findings in pavor nocturnus].

Sleep disorders have an incidence of approximately 65 percent in early childhood. Etiologic there are constitutional and neurotic factors in night terror. Neurophysiologically it occurs at fast arousal out of non-REM-sleep. There are no relations to epilepsy, also not at existence of spike potentials in the EEG. At a cross-sectional examination of 20 children with pavor nocturnus 14 exhibited sharp waves and one SW. The EEG can hint at constitutional factors, retardation of cerebral maturation, but psychological examination is in severe cases more useful for effective therapy.

Brain↗
PubMed1990

[The significance of EEG findings in somnambulism].

In the EEG of 26 patients with somnambulism of an one time transversal examination sharp waves were more frequent than in patients with other diseases, 12 records of 13 children exhibited sharp waves, 5 records of 13 adults, 16 cases exhibited subcortical dysfunctions. There were no relations between epilepsy and somnambulism. Somnambulism was be found preponderantly in episodes of peculiar psychic charge of pupils and young adults. For effective therapy psychological examination is more useful than electrocephalographical examination. The treatment with transquilizer and psychotherapy is rich in meaning.

Adolescent↗
PubMed1990

[Encephalomyocarditis syndrome (EMC syndrome)].

Among 28 autopsy-cases with EMC had been none diagnosed clinically before. Typically we found an interstitial myocarditis and perivenous encephalitis with a preferred participation of the brain stem, eventually resulting in a central failure. There were only 5 cases with meningitis. Myelitis was not found. Former cardiac, less often cerebral lesions are likely risks for the lethal event.

Adolescent↗