[Cisplatin in ovarian cancer: how much and how long?].
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Biomedical subjects
Publications and source records attributed to P Faber.
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The authors examined 200 consecutive patients with pituitary adenomas admitted to the neuroendocrine service at the Montreal General Hospital between 1976 and 1981. The main presenting signs and symptoms were amenorrhea/impotence (70%), headache (46%), and typical acromegalic or cushingoid features (28%). Only 9% had visual field defects, 2% had optic atrophy, and 1% had ocular motility problems. A comparison of our findings with four previous studies has demonstrated an increasing incidence of reproductive system abnormalities and a decreasing incidence of visual abnormalities in patients with pituitary tumor. The reasons for this changing pattern are discussed and the role of the ophthalmologist in the care of these patients is redefined.
Anamnestic data and gynaecological findings of 1036 incontinent women without previous incontinence surgery were examined with the aim in mind to safely establish a diagnosis of stress incontinence. The information given by 234 women (initial group), whose answers were recorded on two different questionnaires, were compared with those of 802 women (control group). By one single information, namely, that urine can be retained for more than three hours, it is possible to predict stress incontinence with an accuracy of 85% in 46% of all incontinent women of the starting group. In a sub-group defined by three data (40% of all women) stress incontinence can be assumed with an accuracy of 90%. As a result, the indication for incontinence surgery in 40% of all examined women could be made with an error rate of 10% only, compared with 26% in the starting group.
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In the case of a combination of urge incontinence and stress incontinence, operative therapy is not successful without previous treatment. In 73% (58/82) of patients treated with 20 mg Butylscopolamine, a significant lowering of the absolute pressure volume values and a significant elevation of bladder capacity could be demonstrated.
41 female patients with a stress incontinence of grade II or III were treated with 2 mg estriol daily over a period of 2-4 months. The function of the bladder was objectively evaluated by urethrocystotonometry. A significant rise of the urethral pressure profile could be demonstrated in 95% (39/41) of patients. An improvement of the stress incontinence by one clinical grade could be shown, but in no case a completely continent bladder sphincter.
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A 32-year-old man survived malignant hyperthermia which developed in conjunction with laparotomy. Muscles biopsy indicated acute necrosis of muscle fibers as well as changes consistent with a latent myopathy. Clinical, laboratory and morphological studies of the relatives revealed familial subclinical myopathy. The hyperthermia resulting from the anaesthesia is thought to be casually related to the myopathy, and members of the family have been warned against this potential risk.
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