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Biomedical subjects

P Fabbri

Publications and source records attributed to P Fabbri.

At least 91 records · Page 5Linked to original sources
PubMed1990

[IgA anti-endomysium antibodies in dermatitis herpetiformis: a sensitive marker of gluten enteropathy].

The paper reports the results of a preliminary study using indirect immunofluorescent methods on serum samples from 20 patients affected by dermatitis herpetiformis in various phases of development and from 7 patients affected by celiac disease in order to document the presence of anti-endomysium IgA antibodies. Serum samples from 10 patients affected by bullous pemphigoid, 1 patients with linear IgA dermatitis and 10 patients with other bullous dermatosis were included as controls. Whereas the presence of these antibodies in varying titres, ranging from 1:10 to 1:80, was confirmed in all case of dermatitis herpetiformis, no antibody activity was observed in control patients. On the basis of these findings and of other published data, it is possible to conclude that these antibodies are directly correlated to intestinal damage, but there is no relationship with the clinical characteristics of skin symptoms or with junctional immunopathological evidence.

Celiac Disease↗
PubMed1990

[The so-called herpes gestationis factor in bullous pemphigoid].

We have investigated the presence of the so-called "herpes gestationis factor" in the serum of fifteen patients with bullous pemphigoid and one patient with cicatricial pemphigoid, that were negative for circulating anti-basement membrane antibodies, using the complement fixation test (substrate: human normal skin, 0 group). We have found herpes gestationis factor in 30% of the serologically negative patients. The presence in the serum of an auto-antibody IgG1 (HGF) highly avid for complement, may determine the false serological negativity in this patient.

Autoantibodies↗
PubMed1990

[Subacute cutaneous lupus erythematosus. Review of the literature and immunological studies of 11 patients].

Following a broad review of the literature referring to the histopathological clinical, immunological and immunogenetic characteristics of a particular variety of recently identified cutaneous lupus erythematosus, namely subacute lupus erythematous, the results of immunopathological studies in 11 patients (6 of whom presented the ring polycyclic variety and 5 the psoriasiform variety) are reported. Serum and skin samples were compared in both varieties and it was noted that there is: 1) a more marked incidence of hypocomplementemia and the presence of immune circulating complexes in the ring-polycyclic variety; 2) a more frequent demonstration of IgG and C at the dermo-epidermic junction and on the edge of superficial derma vessels in the same variety. These findings are interpreted as being the consequence of a more frequent and severe systemic (and above all renal) impairment in the ring-polycyclic variety.

Adult↗
PubMed1989

Plasminogen activators and antiplasmin activity in atopic dermatitis.

Cutaneous deposits of fibrinogen activity in lesional skin, plasmatic fibrinolytic activity, and antiplasmin activity (alpha 2 macroglobulin, alpha 1 antitrypsin and antithrombin III) were evaluated in a group of ten patients with atopic dermatitis and in a sex- and age-matched control group. Plasma fibrinolytic activity was increased in the acute phase of the disease (p less than 0.05). The levels of circulating antiplasmins appeared similar in the patients and the control group. Cutaneous fibrinolytic activity was increased in the acute phase of the disease in 5 of 5 cases, suggesting a role of the fibrinolytic system in the amplification of the inflammatory phenomenon in that phase of the disease. In the chronic lichenified phase, CFA was decreased in 3 of 5 cases leading to an excessive deposit of fibrin in the skin. This could be correlated with the abnormal vascular response (blanching phenomenon). On the basis of these data, the therapeutic use of the antifibrinolytic agents only seems rational in the acute phase of the disease.

Acute Disease↗
PubMed1988

Hair casts.

A case of hair casts in an 8-year-old girl is described. The disorder is rare, the first description dating back to 1897 with a total of only 31 cases reported in the literature since then. The results of research conducted using the optic and electron microscopes (transmission and scanning) are recorded. These studies show that the typical lesion consists of two concentric layers of keratinized cells of differing structure: one resembling the inner layer of Huxley's sheath and the outer layer resembling Henle's layer.

Child↗
PubMed1988

Multicentric reticulohistiocytosis. Report of three cases with the evaluation of tissue proteinase activity.

Three cases of multicentric reticulohistiocytosis showing typical clinical, histologic, and ultrastructural findings are reported. In one, gastric cancer occurred; in the other two cases, severe polyarthritis was the only detectable internal involvement. The serine proteinases, urokinase and tissue-type plasminogen activator, were evaluated both with the autohistographic technique and spectrophotometric assay in lesional skin and synovia. Urokinase levels appeared grossly increased in the lesional synovia and moderately increased in the lesional skin. We suggest that urokinase, presumably released by the activated proliferating histiocytes, may play a major role in the extracellular matrix degradation leading to erosion of cartilage and adjacent bone in multicentric reticulohistiocytosis.

Adult↗
PubMed1986

Increased cutaneous fibrinolytic activity in aquagenic pruritus.

Aquagenic pruritus is a disease in which itchy prickling skin discomfort is evoked by contact with water at any temperature without observable cutaneous lesions. Little is known about its etiology and pathogenesis. Previous reports show that increased levels of blood histamine and cutaneous mast cell degranulation are present before water exposure and that they increase still further with water challenge. This paper shows that fibrinolytic activity is markedly increased both before and after water exposure, while circulating fibrinolytic activity is normal before water exposure in three cases of aquagenic pruritus. A patient who was asymptomatic at the time of the study had no observed increase in fibrinolytic activity either before or after water challenge, suggesting that the remission of symptoms of aquagenic pruritus and normalization of cutaneous fibrinolytic activity are interdependent factors.

Adult↗
PubMed1983

Fibrin deposits and fibrinolytic activity in Schonlein-Henoch syndrome.

Previous reports have shown that alterations in cutaneous and plasmatic fibrinolytic activity are found in cutaneous necrotizing vasculitis (CNV). In a combined investigation with direct immunofluorescence and autohistographic evaluation of tissue fibrinolytic activity in the lesional skin of 20 subjects affected by Schonlein-Henoch (SH) syndrome, there was a marked decrease in cutaneous fibrinolytic activity in SH syndrome accompanied by deposits of fibrin-like material at the dermo-epidermal junction and around the small blood vessels of dermis in affected skin. These data suggest some interactions between decreased fibrinolytic activity, fibrin deposits, and the tissue damage in the development of skin changes in SH syndrome.

Child↗
PubMed1979

Clinico-immunologic correlations in pemphigus and bullous pemphigoid.

Specific immunopathologic data can be found in 95% of patients with pemphigus vulgaris and in 70% of patients with bullous pemphigoid. Antibodies in pemphigus vulgaris can belong to different classes of immunoglobulins and can be destroyed by immunosuppression. Twenty percent of the pemphigus patients had differing results suggesting early recurrence of disease. In patients with bullous pemphigoid, there is great variability in anti-basal zone antibodies. When the disease clears, there is still a wide range of immunologic patterns.

Adult↗
PubMed1978

Alantolactone sensitivity in chrysanthemum contact dermatitis.

A case of occupational chrysanthemum contact dermatitis is reported. Patch tests showed the patient to be sensitized to Chrysanthemum morifolium (Chr M) leaves, flowers, and stems (alcoholic extracts) and to alantolactone. An attempt at desensitization appears to have been successful. Gas chromatography indicated the presence of alantolactone in all the various parts of Chr M, mostly in the flowers. The "maximization test" succeeded in sensitizing guinea pigs to alantolactone.

Adult↗