LOS ANGELES AIR POLLUTION AND RESPIRATORY SYMPTOMS. RELATIONSHIP DURING A SELECTED 28-DAY PERIOD.
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Biomedical subjects
Publications and source records attributed to P F WEHRLE.
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The clinical and clinical laboratory findings in a group of 104 patients with aseptic meningitis associated with ECHO-9 infection were widely variable.A male to female case ratio of 3.7:1 was noted, and the mean age of the female group was significantly greater than that of the male group. The median of cerebrospinal fluid leukocyte counts was significantly higher in the male than in the female patients. Clinical manifestations of the disease were similar to those noted in other reports. Residual paralysis was rare and mild. Further study of the ecology of aseptic meningitis seems indicated for elucidation of the factors governing variability of the disease by sex.
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Means are now at hand, if properly employed, to virtually eliminate clinical poliomyelitis and measles from this country. If such control is to be accomplished, more effective means are required to reach virtually all of the four million infants born each year in this country. Influenza can be suppressed, and improvements in influenza vaccine have been achieved in recent years. It seems likely at this time that at least several of the more important viral diseases can be controlled by utilizing antigens based on the biologic characteristics of the agent, and directed toward the reservoir of infection and the conditions favoring transmission of the infection. The theoretical problem of the effects in man of viruses that are oncogenic in rodents and are derived from various tissue culture systems deserves serious attention. However, this consideration, that of antigenic potency, and other problems reviewed should not be allowed to subvert efforts to solve the real problems that face us, the disability and death resulting from these common infections.
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The more commonly used immunizing agents appear to be safe and remarkably effective when administered according to the present routines. The most serious deficiency at the present in the prevention of pertussis, diphtheria, tetanus, smallpox, and measles lies, not in ineffective antigens, but in administration of the present antigens to a larger proportion of the population. It is expected that appropriate sampling techniques will define areas of poor vaccine utilization in many communities. Proper coordination of immunization efforts in each community should result in a more satisfactory level of immunization.
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Twenty patients with tetanus were treated with human hyperimmune globulin. The mortality rate in the series was 30 per cent. No complications due to the use of this antitoxin were observed.
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