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Biomedical subjects

P F Infante

Publications and source records attributed to P F Infante.

At least 55 records · Page 3Linked to original sources
PubMed1976

Genetic risks of vinyl chloride.

A study of pregnancy outcome among wives of workers exposed to vinyl-chloride monomer (V.C.M.) indicated that, in comparison with controls, there was a significant excess fetal loss in the group whose husbands had a primary exposure to V.C.M., whereas no differences between the groups were observed before the husband's exposures. The difference in fetal death-rates for the post-exposure comparisons was a reflection of a greater fetal loss associated with the wives younger-aged husbands. The significant excess did not seem to be the result of bias from interviewers, respondents, nor from women who had experienced chronic abortions weighting the results. These findings, in conjunction with the demonstration of a mutagenic response via microbial test systems and with observations of significant excesses of chromosomal aberrations among workers exposed to V.C.M., raise scientific and public-health concern for the possible genetic risks of V.C.M. to man.

Age Factors↗
PubMed1975

Dietary fluoride intake from supplements and communal water supplies.

Artificial fluoridation of communal water supplies has resulted in 50% to 60% reductions in dental caries experience accompanied by very little fluorosis. Although vitamin-mineral fluoride supplements also have resulted in significant caries reductions, data are not readily available in the literature in regard to enamel fluorosis in the permanent dentition of children who have received supplements in early infancy. In comparison to estimates of fluoride intake from communal water supplies, the recommended dosage from fluoride supplements results in daily doses that may be two to six times greater, on the average, for the infant less than age 6 months and three times greater for the average 3-year-old. Estimates from both sources bear careful consideration in light of available knowledge and are not necessarily indications for a revision in presently acceptable practice.

Child↗
PubMedDate not supplied

Toxicity of vinyl chloride and polyvinyl chloride as seen through epidemiologic observations.

In 1974, vinyl chloride (VC) was first reported in the scientific literature to induce angiosarcoma of the liver in animals and humans. Further research has now demonstrated the carcinogenicity of this agent to other organs. Target organs for VC now include the liver, brain, and lung, and probably the lymphohematopoietic system. The carcinogenic risk has been extended to jobs associated with polyvinyl chloride (PVC) exposure. This is evidenced by cases of liver angiosarcoma reported among individuals employed in or residing near PVC fabrication facilities and by epidemiologic study demonstrating a significant association between lung cancer and exposure to PVC dust. An association between PVC dust and pneumoconiosis has been demonstrated. On the basis of these findings, experimental bioassays and epidemiologic studies of the carcinogenicity of PVC are clearly in order. Prudent control of PVC in the industrial setting is also clearly indicated.

Brain Neoplasms↗
PubMedDate not supplied

An epidemiologic study of deciduous molar relations in preschool children.

This study indicated that distoclusion decreased significantly with age and was more prevalent in siblings of children with Class II molar relation as compared with the prevalence for the total population. Children of middle socioeconomic status (SES) and girls with Class I molar relation had prevalences of posterior crossbite significantly greater than lower SES children and boys, respectively. Finger habits were highly associated with posterior crossbite (P less than 0.001).

Age Factors↗
PubMedDate not supplied

Dental caries experience in the deciduous dentition of rural Guatemalan children ages 6 months to 7 years.

A study of 528 Guatemalan children indicated that caries prevalence in the deciduous dentition was twice as great as but in the permanent dentition was similar to that for US white children. This is a repeated observation for children of some preindustrial societies. Caries experience was significantly greater in boys. Until 4 years of age, caries attack was greater in the anterior segment of the oral cavity; linear enamel hypoplasia was a predisposing factor.

Child↗