1. Milk and plasma metronidazole and hydroxymetronidazole concentrations were measured in 12 breast-feeding patients following multiple doses of metronidazole (400 mg three times daily). All patients received metronidazole in combination with other broad spectrum antibiotics. 2. Plasma concentrations of both parent drug and metabolite were measured in seven suckling infants. Thirty-five infants were monitored for adverse reactions to maternal metronidazole therapy and two further groups of suckling infants, those whose mothers received either ampicillin alone or no drug therapy, were recruited as controls. 3. The mean milk to plasma ratio (M/P) was 0.9 for metronidazole and 0.76 for hydroxymetronidazole while the mean milk metronidazole concentrations (around Cmax) were 15.5 micrograms ml-1. The mean milk hydroxymetronidazole concentration was 5.7 micrograms ml-1. 4. Infant plasma metronidazole concentrations ranged from 1.27 micrograms ml-1 to 2.41 micrograms ml-1, and the corresponding hydroxymetronidazole concentrations from 1.1 to 2.4 micrograms ml-1. 5. There were no significant increases in adverse effects in infants which could be attributable to maternal metronidazole therapy. 6. Metronidazole was excreted in milk at concentrations which caused no serious reactions in the infants studied. The drug may therefore be administered at doses of 400 mg three times daily to mothers wishing to breast-feed their infants.

Adult↗

PubMed1988

Drug information services in four capital cities in the United Kingdom. 'A tale of four cities'--London (North East Thames), Cardiff, Belfast, Edinburgh.

Dissemination of information, active and passive, was examined in drug information centres in four capital cities in the United Kingdom. The cost of answering an enquiry varied between pounds 5.36 and pounds 10.80. All centres published bulletins. The largest circulation, 4,500 at quarterly intervals, is published in Northern Ireland for all members of the health care team.

Computer Communication Networks↗

PubMed1988

The product is the sum of its parts.

Explore the source record for details and available documents.

Clinical Trials as Topic↗

PubMed1988

Drug sorption to glass and plastics.

The general properties of glass and plastics, the main packaging materials for pharmaceutical products, are described. The use of plastic materials in medicine and pharmaceutical packaging has increased considerably in the last decade, but research on drug/plastics interactions has to a certain extent lagged behind. This review draws together much of the current information on drug/plastic interactions, discussing mechanisms of drug-binding to plastic materials and highlighting potential problems arising from the use of plastic containers, or use of cellulose ester filters for clarification or sterilisation of drug solutions.

Absorption↗