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Biomedical subjects

P F Combes

Publications and source records attributed to P F Combes.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Determination of circulating ectopic beta HCG in solid tumors (author's transl)].

The beta subunit of human chorionic gonadotropin (betaHCG) was performed on the serum of 1 850 patients with microscopically documented non trophoblastic carcinomas. 96 patients (5,2%) had elevated betaHCG plasma levels. The incidence of elevated plasma values varied little from one studied malignancy to another; the highest circulating levels were observed in patient's with bladder carcinomas (22,2%), squamous cell carcinomas of the bronchus (14,2%), pancreatic (20%) and colo-rectum (15,7%) adenocarcinomas. BetaHCG determinations did not improved the diagnostic sensibility of CEA values except for the bladder carcinomas. The short mean survival of patients with positive betaHCG values suggests that elevated ectopic betaHCG, sometime during the clinical course of metastatic maligancies worsens the prognosis.

Carcinoembryonic Antigen↗
PubMed1981

[Dysgerminoma of the ovary: a study of 13 cases (author's transl)].

Thirteen cases of primary ovarian seminoma have been referred to the Claudius Regaud Cancer Center during the last 2 decades, patients' ages ranging form 10 to 41 years with a peak in the 20's. Two patients were treated by surgery as definitive therapy, the others underwent combined radiation therapy (dose range 25 to 45 Gy) following surgical excision. The 2 patients treated by surgery alone had pelvic recurrences, whereas only 2 local failures appeared in the group treated by surgery and radiotherapy. Ten patients are asymptomatic and clinically free of disease after a mean follow-up of 3.5 years, the mean survival time of the series being 6 years. Because of the generally improved prognosis, surgical oophoropexy is recommended before radiotherapy.

Adolescent↗
PubMed1980

The measurement of total lactic dehydrogenase and its isoenzymes in solid tumours.

The routine practice of making enzymatic assessments for the purposes of cancer diagnosis, including the determination of total amount of LDH provides only limited information. However, the total amount of LDH may be used to monitor the effect of chemotherapy or radiotherapy in certain tumours, such as epithelial tumours and germ-cell tumours of the ovaries, non Hodgkin's lymphomas or malignant tumours of the testicles. The differentiation of LDH isoenzymes, with a view to linking their pattern to precise localizations has been studied. In germ-cell testicular tumours, there is a marked increase in LDH 1. In liver metastases, LDH 5 and/or LDH 4 are disturbed in 90% of the cases, while the total amount of LDH is raised in only 72% of the cases. In many cases, the association of a disturbance in the serum ratio of the total amount of LDH and a disturbance in the isoenzymes of LDH 4 and LDH 5 associated with a high level of GGT indicate the presence of liver metastases.

Female↗
PubMed1979

[Thyroid trabecular carcinoma. A clinicopathological entity of poor prognosis? (author's transl)].

The records of 32 patients with trabecular carcinomas of the thyroid gland were critically reviewed from a previously published serie of 138 thyroid cancers referred to the Centre Claudius Regaud, between 1952 and 1973. On the basis of clinico-pathological considerations, it seems possible to divide trabecular carcinomas into two groups. Pure trabecular carcinomas (moderately differenciated follicular carcinomas--WOH) which have a poor prognosis (5 years actuarial survival: 13%) related to high rate of local recurrences, fast metastatic spread to the lung, bad response to suppressive hormonotherapy and lack of 131 iode uptake by malignant tissue. Mixed trabeculo-vesicular carcinomas which have in comparison a fairly good prognosis (5 years actuarial survival: 63%) in keeping with a lower tendency to local recurrences and a useful concentration of radioactive iodine by metastases (most of them located in the skeleton) although dependent on the pourcentage of vesicles in the tumor process. Among differentiated thyroid carcinomas, distinction between pure trabecular and mixed trabeculo-vesicular carcinomas with quantitative determination of vesicules seems of great interest in relation to the therapeutic approach.

Adenocarcinoma↗
PubMed1979

[Cervical lymph nodes metastasis from an unknown primary: diagnosis, treatment and prognosis. A retrospective study of 127 cases observed from 1959 to 1973 (author's transl)].

Authors present clinical records of 127 patients bearing metastatic cervical lymph nodes of unknown origin and referred to the Cl. Regaud Cancer Center between 1959 and 1973. According the prognosis, it is possible to distinguish patients into three groups. In group I, patients (10%) have a lower neck involvement by an adenocarcinoma. The survival is dramatically bad. Group II includes also 10% of patients who have a fairly better prognosis, they are younger people bearing poorly differenciated squamous metastatic lymphonode(s) in the upper neck. Group III. The remaining eighty per cent of patients are heavy drinkers and smokers. Their upper neck is hurt by lymphatic metastases from a well or moderately differenciated squamous cell carcinoma. They have much about the same prognosis than people bearing a known primary carcinoma of the upper aerodigestive tract. After having excluded the first group of patients who is at high risk of having a widely disseminated illness, we can remark that about one half of relapses occurred in the cervical area. A well planned combination of neck dissection and whole cervical lymphatic areas irradiation may further reduce such recurrences and so may enhance the present results: 23% survival 3 years after completion of treatment.

Adenocarcinoma↗
PubMed1979

[Radiation therapy for stage IV carcinoma of the cervix (author's transl)].

Fifty four cases of stage IVa carcinoma of the cervix and treated with radiotherapy were collected between 1971 and 1977. Overall actuarial survival was 16 per cent at 3 years and almost all the deaths occurred before that time. Amongst the factors studied, the initial size of the pelvis tumour and lumbo-aortic lymphography findings were the determing factors in the prognosis. To a lesser extent, the age of the patient, tumour differentiation and the amount of irradiation modified the prognosis. It was thus possible to define, within the stage IVa category, several prognostic groups, the determination of which has therapeutic consequences.

Female↗
PubMed1977

[Kinetics of I-131 fibrinogen in cancer patients: pharmacological approach].

The results obtained in a previous study using 131I fibrinogen in cancerous patients suggested a local intravascular clotting precess. In order to elucidate the mechanism of fibrinogen kinetic abnormalities different drugs, including heparin, prednisone, ticlopidin, aspirin and indomethacin were administered in 68 patients and their effects evaluated by change in the 311I fibrinogen disappearance rate. The results suggest that these drugs may counteract with the early stages of coagulation (kinin-forming system, factor XII) and that abnormal 131I fibrinogen kinetic in cancer would be a non specific phenomenon.

Aspirin↗
PubMed1977

[Thyroid carcinomas. Critical study about 138 observations. Therapeutic deductions (author's transl)].

Between 1952 and 1973, 138 patients with thyroïd carcinoma have been recorded. From the critical study of these cases, the pathological, etiological and clinical features have been studied. Different therapeutic modalities are evaluated from these cases. Surgery was always used when possible. A hemithyroïdectomy was realised most often. We stress that sterilisation was obtained by 131I treatment in plurifocal metastasis, particularly in pulmonary metastasis, only when the iodine uptake was sufficient. Survival has been evaluated according to the pathology: papillary and vesicular carcinomas have a good prognosis (the papillary and vesicular survival rate at 10 years reaches respectively: 65% and 64%). Anaplastic carcinomas have a bad prognosis (the survival rate at 5 years is 18%, at 10 years, 0%. These results are similar to those published by differents authors. At the opposite, trabecular carcinomas have a very short survival (8% at 5 years, 7% at 10 years) which is very unusual in well differentiated thyroïd carcinomas. It has to be isolated from the others.

Age Factors↗
PubMed1977

[Evaluation of the results of radiotherapy in 14 cases of malignant thymoma. Therapeutic prospects].

The authors present a critical review of 14 cases of malignant thymomas. They point out that the development of the tumours is similar to Hodgkin disease's (13 relapses in contiguous areas), that surgery is never sufficient for cure and that radiosensitivity is high (in 8 patients radiotherapy alone results in a total and early regression of the tumour). Therefore the authors propose a complementary post-operative treatment by limited irradiation and MOPP type polychemotherapy. This temporary choice of treatment can be reevaluated after further case studies. To facilitate this they wish that a cooperative project could gather the rare and dispersed observations of different centers.

Adult↗
PubMed1977

[Influence of the diagnosis of Hodgkin's disease on the quality of life of cured patients].

Authors present results of an inquiry dealing with familial and socio-professional reinsertion of 130 patients who have been treated for Hodgkin disease. On a family point of view, after treatment, the rate of single people is higher than in general population. Even though one can observe marriages, and feminine sterility is rare, the number of children by married couple remains low. There is no change in rate of house moving. Most of cured patients return to work. This fact is related to duration of treatment, but variations depend essentially of familial situation, kind to work and quality of previous social insurance. For two groups of people risk of unemployement is higher: agricultural labourers who are often dismissed and contractual civil servants who meet with difficulties to be established. Definitive invalidity is rarely conceded by wearied social organisms. Finally cured patients appear most of the time comparable with healthy population. However they meet with important difficulties to get a loan or to contract a life insurance. Premiums are frequently raised and policies restricted. Difficulties are not related to organic sequelae. Cured patients still remain suspicious for their entourage and employer, that bring them about to hide the pathologic episode.

Adolescent↗
PubMed1976

[The half-life of iodine 131-labelled fibrinogen in cancer patients. Effects of heparin].

Sixty nine patients suffering from malignant tumours at different stages of their development underwent a kinetic study of fibrinogen 131I with external counting over the tumour and a study of haemostasis including P.D.F. The 1/2 T of fibrinogen 131I is shortened: 2.52 +/- 0.09 days (normal: 3.89 +/- 0.11 days.) The abnormality is proportional to serum P.D.F. levels (r=0.99). External counting demonstrated the uptake of labelled fibrinogen in the tumour. Heparine (15000 U/24h) restores the 1/2 T of fibrinogen to normal in 95 p. cent of cases. The results suggest the existence of a localised compensated intravascular coagulation process inside the tumour. Possible consequences of that phenomenon are discussed.

Blood Coagulation↗