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P Enders

Publications and source records attributed to P Enders.

11 recordsLinked to original sources
PubMed2001

V gamma 2 TCR repertoire overlap in different anatomical compartments of healthy, unrelated rhesus macaques.

Gammadelta T cells show preferential homing that is characterized by biased TCR repertoire at different anatomical locations. The processes that regulate this compartmentalization are largely unknown. A model that allows repeated multiple sample procurement under different conditions and enables with relatively straightforward extrapolation to a human situation will facilitate our understanding. The peripheral blood Vgamma2 T cell population is the best-characterized human gammadelta T cell subset. To determine its diversity at multiple immunocompartments matching blood, colon, and vagina samples from rhesus macaques were investigated. Four joining segments used in Vgamma2-Jgamma transcripts were identified, including one segment with no human counterpart. Like in humans, the rhesus peripheral blood Vgamma2 TCR repertoire was limited and contained common sequences that were shared by genetically heterogeneous animals. Furthermore, this subset comprised several phylogenetically conserved Vgamma2 complementarity-determining region 3 (CDR3) motifs between rhesus and humans. Common sequences were also found within the colon and vagina of the same animal, and within the peripheral blood and intestine of different unrelated animals. These results validate rhesus macaques as a useful model for gammadelta TCR repertoire and homing studies. Moreover, they provide evidence that the concept of limited but overlapping Vgamma TCR repertoire between unrelated individuals can be extended including the mucosa of the digestive and reproductive tract.

Amino Acid Motifs↗
PubMed1998

Surface Behavior of Spread Sodium Eicosanyl Sulfate Monolayers.

The surface behavior of spread sodium eicosanyl sulfate monolayers is characterized by determining the dilational moduli from different pi/A isotherms and from surface stress relaxation experiments in the short-time range (<10 min). The elasticities derived from the pi/A isotherms differ depending on the experimental conditions. The quasi-equilibrium isotherm displays a plateau in the range of coexistence of the condensed and the expanded phases and strong increases caused by the formation of a solid-like phase. In contrast, nonequilibrium pi/A isotherms yield effective elasticities showing a maximum within the phase coexistence range. The formation of a solid phase cannot be detected because of the onset of monolayer collapse. Different stress relaxation experiments were carried out for monolayer compression and dilation using transient drop volume jumps. Depending on the experimental run, these experiments lead to consistent and complementary results with those derived from pi/A isotherms under comparable conditions. The stress recoveries yield a relaxation time, a dilation viscosity, and a parameter characterizing the homogeneity of the relaxation process. The stress relaxation is interpreted accounting for both the nonequilibrium between the monolayer and the bulk phase and the nonequilibrium within the monolayer. The influence of alkylsulfate hydrolysis on the presented results was checked. It was found that within the time scale of the experiments no influence of hydrolysis could be detected. Copyright 1998 Academic Press.

Journal Article↗
PubMed1995

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Journal Article↗
PubMed1988

[Otogenic brain abscess and middle ear cancer].

An uncommon case is reported in which both a brain abscess and a carcinoma of the middle ear were diagnosed at the same time. Before the histology was known, a cholesteatoma was thought to be the cause of the brain abscess. The difficulties in the differential diagnosis are discussed.

Aged↗
PubMed1984

Interlaboratory survey on thallium in urine.

Quality assurance of analytic results was legalized in the Federal Republic of Germany by the law regulating the calibration of measuring devices of July 11, 1969, and the ordinance concerning the exception from compulsory calibration dated June 29, 1970. Accordingly, in the field of health care the Guidelines of the Medical Society of West Germany for the realization of quality assurance activities have to be followed. Since January 1, 1974, the law regulating the calibration of measuring devices has been fully effective. In the field of legal medicine the clinico-toxicologic analysis is considered to be a part of health care. As far as quantitative determinations are considered, these analyses have to follow the regulations mentioned above. To fulfil the basic program, adequate control samples are necessary. For toxicologic analysis there have been no control samples so far. Therefore, a control sample for thallium has been developed which can be used for long- and short-term interlaboratory surveys. The results are reported.

Forensic Medicine↗
PubMed1978

Anticholinergic activity of two tricyclic antidepressants.

Using a double-blind crossover Latin square design, the authors evaluated the peripheral anticholinergic and central nervous system effects of three dose levels of two tricyclic antidepressants in female volunteers. Results showed that 5 hours after drug administration, desipramine (50 and 100 mg) caused significantly less reduction in salivation than did amitriptyline. Amitriptyline produced more sedation (Clyde Mood Scale) and a greater number of subjective complaints than did desipramine. These results are consistent with anticholinergic profiles from animal experiments and suggest that clinically meaningful differences may exist among tricyclic antidepressants.

Adult↗
PubMed1976

[Hyperinsulinism. Neurological and psychiatric aspects (author's transl)].

A case of a patient with hyperinsulinism due to insulinoma associated with neurological and psychiatric disturbances including EEG alterations is reported. The hunger test as well as the i.v. tolbutamid test proved to be of diagnostic importance. In addition, the electroencephalographic studies combined with blood sugar analyses before and after 50 g glucose, orally, showed a reversibility of the EEG alterations together with normalization of the blood surgar levels. These results point to the possibility of differentiating biochemical from structural cerebral lesions associated with hyperinsulinism.

Adult↗