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Biomedical subjects

P Eggert

Publications and source records attributed to P Eggert.

30 records · Page 2Linked to original sources
PubMed1990

How necessary is a chromosomal analysis in growth-retarded girls?

In growth-retarded girls, shortness may be the only clinical sign of Turner syndrome. Therefore recommendations have been published that a chromosomal analysis should be carried out in every girl showing growth retardation. The present study was carried out to examine whether the head circumference of small girls can serve as a criterion and hence limit the need for expensive chromosomal analysis. The head circumferences of 45 girls with Turner syndrome were compared with those of 41 growth-retarded girls. It could be shown that the heads of the patients with Turner syndrome had a normal circumference, whereas the heads of the control group were significantly smaller. In view of this result, the risk of overlooking Turner syndrome in diagnosing growth retardation without a chromosomal analysis could be estimated to be 1:9000. The conclusion is drawn that a chromosomal analysis is not necessary in girls whose growth retardation is combined with a small head circumference and who do not show other malformations.

Chromosome Aberrations↗
PubMed1988

On the efficacy of various irradiation regimens in phototherapy of neonatal hyperbilirubinaemia.

The efficacy of various irradiation regimens in phototherapy of neonatal hyperbilirubinaemia was analysed. One hundred and one newborns were assigned to three groups at random. The best results were achieved when six special blue fluorescent lamps were used and the sides of the incubator were draped with white cloth to reflect the light diffusely. This simple measure increased the therapeutic effect by approx. 35%. Compared to standard phototherapy units equipped with fluorescent lights, a halide lamp was no more effective. The results of the clinical trial confirm the conclusions drawn from measurements, published previously. According to those findings, irradiating large areas of skin as homogeneously as possible should produce optimum results. Using a lamp with a large surface in combination with diffusely reflecting areas should best meet this requirement.

Bilirubin↗
PubMed1986

[Dermatitis solaris in newborn infants following phototherapy with a halogenide radiation unit].

Two cases of dermatitis solaris in newborns after phototherapy with a halide burner gave reason to measure the UV-B radiation emitted by the instrument used. Values between 0.8 microW/cm2 and 1.8 microW/cm2 were found. In small areas under the lamp housing the intensities of the UV-B radiation reached up to 10 microW/cm2. These high intensities are caused by the design of the lamp housing. Especially in connection with aluminium foil used to increase the efficacy of the therapy skin leasons as described may be produced.

Bilirubin↗
PubMed1985

The distribution of radiant power in a phototherapy unit equipped with a metal halide lamp.

The effective radiant power of a metal halide lamp for phototherapy of neonatal jaundice was measured in an incubator. This new lamp is characterised by an extremely heterogeneous field of irradiance with a high intensity in the centre and a marked decrease towards the sides. The mean radiant intensity in a central area (20 X 40 cm) of the incubator can be compared with the values achieved with standard fluorescent lamps in an incubator lined with white cloth. As the field of irradiance is more homogeneous in the latter case, advances in therapy are not to be expected from the use of metal halide lamps in their present form.

Humans↗
PubMed1984

On the distribution of irradiation intensity in phototherapy. Measurements of effective irradiance in an incubator.

Knowledge of the effective irradiation dose is a prerequisite to predicting the efficacy of phototherapy. To gain this information, the field of irradiation of a phototherapy lamp was measured in an incubator. It became apparent that the radiant power is extremely heterogeneously distributed in the incubator. By decreasing the distance from the lamps, the radiant power is increased, with the heterogeneity of irradiation growing considerably at the same time. Lining the incubator with reflecting cloth results in a greater homogeneity of the field of irradiance and an increase in radiant power. Moreover, the lining causes a doubling of the indirect reflected radiance. The findings presented here are discussed in view of their importance for doses in phototherapy. It can be concluded that to increase the efficacy of phototherapy, lining the incubator with reflecting cloths is a more effective measure than moving the patient closer to the lamp.

Dose-Response Relationship, Radiation↗
PubMed1984

[A simple measuring device for monitoring radiation in phototherapy].

A simple low cost device is described for measuring the irradiation intensity used in phototherapy of hyperbilirubinemia in newborns. The spectral selectivity of the sensor is adapted to the most effective wavelength for phototherapy. The device can be calibrated in W/m2. A description of calibration is given. When fluorescent lamps adapted to phototherapy are used, the accuracy of the device can be compared to that of commercially manufactured units. The sensitivity is sufficient to measure differences of irradiance significant for the therapy. The device is suitable to quantify phototherapy of the newborn infant suffering from hyperbilirubinemia.

Humans↗
PubMed1980

Periodic microflow pattern measured with a new microflow probe within the rat kidney cortex.

With a newly developed microflow probe of high spatial resolution periodic changes of flow occurring within a tissue sphere of a radius of less than or equal to 50 micrometer have been observed. The frequency distribution of the periodic changes of flow was similar to the frequencies observed earlier with different techniques in the same preparation and in other organs (Basar and Weiss, 1970; Weiss and Thiemann, 1973). Preferred frequencies were: 0.02 Hz, 0.06 Hz and 0.1 Hz. Manufacture, calibration, the complete setup, and the estimation of the power of spatial resolution of the microflow probe are described. Periodic heating of the flow-sensing thermocouple at the tip of the probe (luminal diameter less than or equal to 10 micrometer) obviates the use of a reference thermocouple, renders the system (relatively) insensitive against uncontrolled changes of ambient temperature, and thus allows measurements with a very high sensitivity.

Animals↗
PubMed1979

Periodic changes in blood flow in the in vivo rat kidney.

The frequency response of the blood flow through the rat kidney in vivo has been studied. A piston controlled by a random-signal generator compressed the abdominal aorta proximal to the renal artery eliciting stochastical arterial pressure changes of an amplitude of less than or equal to 5 mm Hg. This small amplitude allowed to study the system under physiological conditions. In accord with earlier results from isolated kidneys pressure induced maxima of flow resistance were found at 0.005 Hz and at 0.1 Hz, thus demonstrating that in vivo humoral and/or nervous factors do not significantly alter the renal vascular response to changes of arterial pressure.

Animals↗
PubMedDate not supplied

[Age- and weight-related dosage of dDAVP in the treatment of primary nocturnal enuresis].

BACKGROUND: In treating primary nocturnal enuresis the dosages recommended for an intranasal application of dDAVP are 20, 30 or 40 microgram depending on the response. Dosages that take the patient's weight or age into account are not commonly used until now. PATIENTS AND METHODS: In the present prospective study including 43 children therapeutic success was therefore evaluated on the basis of the dosage that was standardized according to both age and weight of the patients. The patients' weight ranged from 16.5 to 98 kg, their age from 6 to 14.9 years. RESULTS: The dDAVP dosages that were applied ranged from 0.3 and 2.4 microgram/kg and 3.74 and 15.3 microgram x age/kg respectively. Therapeutic efficacy was at 63 %. CONCLUSIONS: The results suggest an ideal weight-related dosage of 1 microgram x weight or rather an age- and weight-related dosage of 8 microgram x weight/age. A higher dosage evidently is of little use since there was a significant difference between the non-responders and the responders (p < 0.01) with the non-responders not even reacting to higher dosages.

Administration, Intranasal↗