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Biomedical subjects

P Economopoulou

Publications and source records attributed to P Economopoulou.

At least 19 recordsLinked to original sources
PubMed2004

Effect of PI-HAART on the prevalence of oral lesions in HIV-1 infected patients. A Greek study.

OBJECTIVE: To investigate the association between the prevalence of oral lesions and highly active antiretroviral therapy (HAART) including a protease inhibitor (PI). DESIGN: Prospective study. PATIENTS AND METHODS: Ninety-five consecutive patients, attending an AIDS Unit, in Greece entered the study. Fourty-four patients were receiving PI- HAART, 14 patients were on double antiretroviral therapy, and 37 patients were not receiving antiretroviral therapy at the time of oral examination. Oral lesions were diagnosed by established presumptive clinical criteria. MAIN OUTCOME MEASURES: Oral lesions were scored. CD4 counts and viral load were determined and related to the prevalence of oral lesions. RESULTS: Oral lesions, and specifically oral candidiasis, were significantly reduced (P < 0.001) in patients receiving PI-HAART. Oral lesions were significantly increased in patients with CD4 counts <200 cells microl(-1) and viral load >20,000 copies ml(-1) (P < 0.001). The percentage of patients, with lesions on PI-HAART, and with CD4 < 200 and viral load >20,000 was 1.5 times lower (37.5%vs 58.8%, P < 0.001) than that of patients not receiving antiretroviral therapy, but with similar immune and viremic status. CONCLUSIONS: Oral lesions were significantly reduced in patients on PI-HAART. A direct anticandidal effect of PI was suggestive and seemed to have accounted, beyond the HAART-related immune reconstitution, for the reduction of candidiasis and all other oral lesions.

Adult↗
PubMed2000

Expression of E-cadherin, cellular differentiation and polarity in epithelial salivary neoplasms.

To investigate whether expression of E-cadherin correlates with polarised tissue organisation, grade or tumour type in salivary neoplasms, frozen sections from 30 salivary gland neoplasms were stained immunohistochemically for E-cadherin using the antibody HECD-1 and compared to the staining patterns in five samples of normal salivary gland. Lesions with areas of lack of staining were restained at two higher antibody concentrations. Normal salivary gland stained strongly around the periphery of acinar and ductal cells. Neoplasms mostly stained strongly regardless of neoplasm type. Reproducible loss of expression was found only in epithelial cells showing stromal or plasmacytoid (hyaline) differentiation in pleomorphic adenoma. Low- and high- grade mucoepidermoid carcinomas, adenocarcinoma NOS and carcinoma ex pleomorphic adenoma showed focal loss of expression but this was not related to tissue architecture, differentiation or invasiveness. We conclude that the relationship seen between E-cadherin expression and cell polarity/glandular organisation in breast and colon does not appear to exist for salivary gland neoplasms in which the diversity of architectural patterns precludes detection of any simple relationship. E-cadherin expression seems unlikely to be a useful marker for diagnosis or prognosis in salivary neoplasia in general.

Biomarkers, Tumor↗
PubMed1998

Oral histoplasmosis as an indicator of HIV infection.

Histoplasmosis as a serious opportunistic infection in association with AIDS has assumed considerable importance. We have gathered 20 case reports from the literature of oral histoplasmosis in HIV-infected patients. In some cases, oral lesions appear to be the primary or only manifestation of disease. We report one such case of oral histoplasmosis in a bisexual man who was seen with ulcerations on the palate and proved to be infected by HIV.

AIDS-Related Opportunistic Infections↗
PubMed1990

Globular hyaline masses in the stroma of ameloblastoma: histopathologic and histochemical study.

A microscopical study of 15 intraosseous ameloblastomas revealed the presence of globular hyaline masses in only one of them (6.6%). These masses were confined to the stroma of plexiform areas and especially in regions undergoing cystic degeneration. They were periodic acid-Schiff positive and showed an affinity for acid dyes such as phloxine, acid fuchsin, orange G and picric acid. Regarding their pathogenesis, they are probably formed from extravasation of plasma glycoproteins, condensing and taking up a spheroidal shape in the liquid micro-environment of stromal degeneration under the influence of capillary phenomena.

Aged↗
PubMed1989

[Histological and histochemical observations on the horny pearls of pleomorphic adenoma].

An unusual case of pleomorphic adenoma displaying numerous horny pearls is described. The tumour arose in the right lateral lingual border of a 33-year-old man. In many pearls the cores were organized in two separate portions with distinct structural and histochemical features. The narrow peripheral portion had a compact structure and was rich in keratin since it contained cystine and was coloured with acid dyes of intermediate molecular size. The central portion was characterized by a loose texture and its histochemical profile (affinity for acid dyes of large molecular size, weak alcianophilia, vivid binding of colloidal iron) resulted from the existence of acidic mucosubstances in the cell coating of the neoplastic keratinized cells. These observations suggest that certain similarities exist between the processes of normal keratinization and squamous metaplasia in pleomorphic adenoma.

Adenoma, Pleomorphic↗
PubMed1988

Gingival manifestations of childhood cicatricial pemphigoid.

Cicatricial pemphigoid (CP) is found almost exclusively among middle-aged and elderly persons. This article describes a rare case of CP in a 14-year-old girl; it appeared on the mandibular anterior gingiva as desquamative gingivitis. Histologic examination of the lesions showed a subepithelial bulla. Immunofluorescence of gingival biopsy revealed immunoglobulin G, protein C3, and faint immunoglobulin A deposition along the basement membrane zone; results for normal skin were negative. Indirect immunofluorescence produced negative results. There are only six documented cases of childhood CP previously reported in the literature. The clinical and immunologic features of these cases are reviewed.

Adolescent↗
PubMed1986

Dermatitis herpetiformis: oral lesions as an early manifestation.

Dermatitis herpetiformis is an uncommon chronic skin disease that rarely affects the oral cavity. An unusual case of dermatitis herpetiformis, starting with oral lesions 6 months prior to the onset of skin lesions, is reported. The diagnosis was based on the typical histopathologic features and on positive direct immunofluorescence. The literature is briefly reviewed. Evaluation of laboratory findings, clinical picture, and response to sulfones is essential to the final diagnosis and is emphasized.

Dermatitis Herpetiformis↗
PubMed1986

Aneurysmal bone cyst of the jaws. Review of the literature and report of 2 cases.

Strictly speaking, the aneurysmal bone cyst is not a true cyst. It is a lesion characterized by replacement of bone by fibro-osseous tissue containing blood-filled cavernous spaces. It is usually treated by surgical curettage, and access within the jaws may sometimes be difficult. We reviewed the world literature and found 63 cases of aneurysmal bone cysts involving the face, 22 reported in the maxilla, and 63 in the mandible. One was found in the zygomatic arch. Of the patients reported, 88% were younger than 30 years old; there was an equal sex distribution. Included in this report, are two cases of our own, one involving the maxilla and one the mandible.

Adult↗
PubMed1986

Maxillary angiosarcoma.

A malignant tumor of mesenchymal origin, angiosarcoma, is a rare entity deriving from the endothelium of the blood vessels, that very infrequently is encountered in the jaws. 46 such cases have only been reported.

Aged↗