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Biomedical subjects

P E Thompson

Publications and source records attributed to P E Thompson.

At least 37 records · Page 2Linked to original sources
PubMed1975

Cryopreservation of infective larvae of Dipetalonema viteae.

infective larvae of Dipetalonema viteae produced infections in Mongolian jirds (Meriones unguiculatus) after storage of infected ticks (Ornithodoros tartakovskyi) in the presence of dimethyl sulfoxide (DMSO, 5%) for 7 or 595 days in liquid nitrogen (-196 C). Infectivity of these larvae was only partially impaired. Microfilaremias of test jirds were generally lower than those of control jirds given nonfrozen larvae; however, the majority of test jirds developed microfilarial counts suitable for use in infecting ticks. In contradistinction, larvae frozen free of the tick failed to retain infectivity. Apparently the tick, in conjunction with DMSO, protects the larvae during freezing and thawing.

Animals↗
PubMed1973

Comparative effects of 3-ethyl-8-methyl-1,3,8-triazabicyclo(4,4,0)decan-2-one and diethylcarbamazine against Litomosoides carinii in rodents.

3-Ethyl-8-methyl-1,3,8-triazabicyclo[4,4,0]decan-2-one and diethylcarbamazine were tested comparatively against Litomosoides carinii in Mongolian jirds and cotton rats. The drugs were compared in jirds by oral and by intraperitoneal administration. Comparisons in cotton rats were done by intraperitoneal administration. The drugs were given in a wide range of doses twice daily for 4 consecutive days. Parameters used for judging efficacy included the rate, degree, and duration of microfilaremia suppression as well as effects on adult worms. The two drugs exhibited similar strong but transient effect against microfilariae; neither drug had appreciable effect in killing adult worms.

Administration, Oral↗
PubMed1972

Interactions of differentiated primary sex factors in Chironomus tentans.

Different populations of Chironomus tentans, possibly representing geographically isolated races, have two differentiated genic mechanisms of sex determination involving either a dominant male-determining factor in the left arm of chromosome 1 or a dominant female-determining factor at the right tip of chromosome 1. In crosses between these populations, the male-determining factor is epistatic to the female-determining factor. No evidence of intersexuality has been found in such crosses.

Animals↗