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Biomedical subjects

P E Stanley

Publications and source records attributed to P E Stanley.

At least 19 recordsLinked to original sources
PubMed1999

Bioluminescent fusion conjugates and bioluminescent immunoassays: 1988-1998

The first part of this survey focuses on immunoassays and related ligand:binder assays (receptor:ligand, DNA probe) that use either a luciferase or a photoprotein as a label. In addition, references to assays that use a conventional label detected using a bioluminescent assay are included. The second part of the survey collects together references to publications on recombinant fusion proteins in which one of the fused proteins is bioluminescent (e.g., a luciferase or a photoprotein). References are cited by year and then alphabetically by first author. Copyright 1999 John Wiley & Sons, Ltd.

Journal Article↗
PubMed1999

Time-resolved fluorescence: 1996-1998

Luminescence continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence which, up until 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named journal these searches are expanding to reflect the journal's wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemiluminescence but also fluorescence, time resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence. The compilers would be pleased to receive any comments from the readership. Copyright 1999 John Wiley & Sons, Ltd.

Journal Article↗
PubMed1999

Sonoluminescence: 1996-1998

The journal continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence, and which have, up to 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named Journal these searches are expanded to reflect the Journal's wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemi--luminescence but also fluorescence, time-resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence, etc. The compilers would be pleased to receive any comments from the readership. Contact by E-mail: L. J. Kricka (larry_kricka@pathla.med. upenn.edu), and P. E. Stanley (stanley@lumiweb.com). Copyright 1999 John Wiley & Sons, Ltd.

Journal Article↗
PubMed1999

Electrochemiluminescence: 1996-1998

The journal continues to provide comprehensive literature surveys which will be published in most issues. These are a continuation of the literature surveys begun in 1986 in the Journal of Bioluminescence and Chemiluminescence, and which have up to 1998, encompassed more than 6000 references cited by year or specialized topic. With this newly named Journal these searches are expanded to reflect the Journal's wider scope. In future we will cover all fundamental and applied aspects of biological and chemical luminescence and include not only bioluminescence and chemi--luminescence but also fluorescence, time-resolved fluorescence, electrochemiluminescence, phosphorescence, sonoluminescence, lyoluminescence and triboluminescence, etc. The compilers would be pleased to receive any comments from the readership. Contact by e-mail: L. J. Kricka (larry_kricka@path1a.med. upenn.edu), and P. E. Stanley (stanley@LUMIWEB.COM). Copyright 1999 John Wiley & Sons, Ltd.

Journal Article↗
PubMed1992

A survey of more than 90 commercially available luminometers and imaging devices for low-light measurements of chemiluminescence and bioluminescence, including instruments for manual, automatic and specialized operation, for HPLC, LC, GLC and microtitre plates. Part 1: Descriptions.

This survey was compiled in January and February 1992 from information available in public domain literature requested by and supplied to the author by numerous companies in the previous two months. More than 90 luminometers (manual, automatic, microtitre plate, HPLC, LC, GLC, imaging and specials) from more than 60 companies are included. Each company was invited to supply company brochures, technical details, user manual and information about software and any other information concerning their product(s). The response varied from a single information sheet to promotional material and up to full product information and specification with technical details, user manuals and scientific publications. Where an instrument is dedicated to a single task the company may have only provided details relevant to accomplishing that task. Part 2 of this survey will contain photographs of some of the luminometers. It is intended that updates to this review will be published at least annually in this journal and suppliers are invited to provide full technical details of new luminometric equipment to the author.

Allergy and Immunology↗
PubMed1992

A survey of more than 90 commercially available luminometers and imaging devices for low-light measurements of chemiluminescence and bioluminescence, including instruments for manual, automatic and specialized operation, for HPLC, LC, GLC and microtitre plates. Part 2: Photographs.

Part 1 of this survey comprised a description of the luminometers (J. Biolumin. Chemilumin. 7, 77-108 (1992)) and was compiled in January and February 1992 from information available in public domain literature requested by and supplied to the author by numerous companies in the previous two months. This part includes photographs of around 40 of these instruments. It is intended that updates to this review will be published at least annually in this journal and suppliers are invited to provide full technical details of new luminometric equipment to the author.

Autoanalysis↗
PubMed1989

A review of bioluminescent ATP techniques in rapid microbiology.

Use of firefly luciferase to assay adenosine triphosphate (ATP) extracted from microorganisms provides an easy means to enumerate microbes within minutes. The small amount of light produced is proportional to ATP and thus microbial number. The average bacterium contains around 10(-15) g ATP per cell. Present reagents permit detection of 10(3) cells per tube. Luminometers currently on the market detect about 10(-12) g ATP. Proper extraction of ATP from the microbes is an essential part of any protocol, as is the removal of non-microbial ATP from, for example, somatic cells also present in samples. The technique may be applied to a wide range of samples, for example food and beverages and clinical samples such as urine. The ATP assay gives a global measure of microbial numbers, i.e. it is not species specific unless a species separation step is included in the protocol.

Adenosine Triphosphate↗
PubMed1981

The predictive value of the serum digoxin concentration in the management of hospitalized patients.

Serum digoxin concentration (SDC) was compared with clinical and ancillary predictors as a guide to adjustment of digoxin dose and as a test for digitalis toxicity in a total of 76 hospitalized patients during a period of 9 months. The mean SDC (3.6 +/- 2.5 nmoles/liter) associated with unexpected discontinuation of therapy was significantly higher (p less than 0.001) than that (1.1 +/- 0.6 nmoles/liter) associated with unaltered digoxin dose, while the mean SDC (0.6 +/- 0.4 nmole/liter) associated with unexpected dose increase was significantly lower (p less than 0.05). There was no significant association between other pharmacokinetic or pharmacodynamic predictors and therapeutic intention. There was a 13% incidence of confirmed digitalis intoxication. The mean SDC (3.6 +/- 1.9 nmoles/liter) of patients presenting and confirmed as digitalis toxic was significantly higher (p less than 0.001) than that (1.4 +/- 0.6 nmoles/liter) involving a situation in which digitalis toxicity could not initially be excluded by other means. The predictive value of an SDC greater than or equal to 2.6 nmoles/liter for toxicity was 80%, and its efficiency for diagnosing both toxicity and nontoxicity was 95%. The SDC was thus shown to be a valid test of digitalis toxicity and to provide extraordinary information enabling the clinician to modulate digoxin therapy precisely.

Cardiovascular Diseases↗