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Biomedical subjects

P E Robin

Publications and source records attributed to P E Robin.

At least 37 records · Page 2Linked to original sources
PubMed1984

A prospective trial of unilateral grommets for bilateral secretory otitis media in children.

Fifty-four children with established chronic secretory otitis media, who had failed to respond to medical measures were treated with adenoidectomy and insertion of 1 grommet on a side chosen at random. Both sides improved and remained significantly improved at 12 months (P less than 0.001). At 3 months, the side with the grommet improved significantly more than the other side (P less than 0.05) but at 12 months there was no significant difference between the 2 sides (P greater than 0.1).

Adenoidectomy↗
PubMed1981

Diagnostic errors in cancers of the nasal cavity and paranasal sinuses. The essential role of surgery.

Two hundred eighty-two cases of 624 cases of carcinoma of the nasal cavity and paranasal sinuses were studied. All had a clinical evaluation of the extent of carcinoma, followed by surgical procedures. By a process of defining 13 possible compartments or extensions and enumerating them before and after surgery, it was possible to show that approximately one third of the cases had errors in preoperative assessment. Underestimates preponderated. It is suggested that diagnosis is one important role of surgery, in addition to the directly therapeutic effect of excision. Surgery is also essential as a guide to further excision and to the accurate application of radiotherapy treatment fields.

Diagnostic Errors↗
PubMed1981

Laryngeal closure in the management of severe long-standing bulbar palsy in a child.

An 11-year-old girl developed a severe brainstem encephalopathy thought to be due to multiple sclerosis. She has been left with a severe long-standing bulbar palsy and a permanent tracheostomy. A new operation of laryngeal closure is described which gave relief from recurrent aspiration pneumonia and cardiorespiratory failure.

Bulbar Palsy, Progressive↗
PubMed1981

Treatment of carcinoma of the nasal cavity and paranasal sinuses.

The results of the radical treatment of 528 cases of carcinoma of the nasal cavity and paranasal sinuses are presented. These cases were analysed according to treatment modes of surgery of radiotherapy alone and surgery, radical or subradical, with radical radiotherapy. Of necessity the survey is retrospective but the results can be interpreted as demonstrating that while surgery without radiotherapy is appropriate to certain tumours near the nasal vestibule, to transitional cell carcinoma in men, and to some salivary carcinomas, for the remainder surgery, either radical or subradical with radiotherapy, is appropriate. No significant difference can be shown between radical and subradical surgery, when combined with radiotherapy. Radiotherapy alone appears inappropriate.

Adenocarcinoma↗
PubMed1980

Regional node involvement and distant metastases in carcinoma of the nasal cavity and paranasal sinuses.

Of 624 cases of carcinoma of the nasal cavity and paranasal sinuses the presence or absence of metastasis to the regional nodes or to distant sites was recorded. Regional nodes were involved in 14.3 per cent, varying according to site and histological type. Disseminated metastases were found in 1.6 per cent. The prognosis for those with involved nodes was severely reduced, and for those with distant metastases it was negligible. This bleak outlook should be considered when treatment is being planned.

Female↗
PubMed1980

Homografts in tympanoplasty: will they be a disaster? an experimental study.

Experimentally transposed homograft ossicles in rats showed behaviour less stables than autografts, all being resorbed within 48 weeks. Using information derived from this and other experimental work in both animals and humans it is predicted that homografts will be unstable in humans in the long term.

Animals↗
PubMed1979

Lateralisation of tumours of the nasal cavity and paranasal sinuses and its relationship to aetiology.

Lateralisation was studied in 601 cases of carcinoma of the nasal cavity and paranasal sinuses. Squamous and anaplastic carcinomata and adenocarcinoma had a pronounced left-sided predominance in the ethmoid and to a much lesser extent in the nose. The results of a study of 298 cases of septal defection are invoked in support of the hypothesis that squamous and anaplastic carcinomata, as well as adenocarcinoma, are caused by exogenous factors.

Adenocarcinoma↗
PubMed1976

Study of autogenous transposed ossicles, bone and cartilage in man.

Study was made of 28 ossicles from 22 ears with chronic otitis, 12 autogenous transposed ossicles removed after varying periods of time, normal and 4 transplanted pieces of bone, and normal and 2 transplanted pieces of cartilage. The transposed ossicles were found to be dead, apart from certain special instances, showing pathology similar to non-transposed ossicles. Transplanted bone was also dead. Cartilage was vital. These autogenous transplants showed no evidence of rejection and less chronic inflammation than would be anticipated. It is suggested that autogenous ossicular or bone transplants in man act as inert but not rejected implants, while cartilage may remain viable.

Bone Transplantation↗
PubMed1976

Radical neck dissection.

Radical neck dissection was described in 1906, and the following half century saw it being increasingly accepted without any significant change. More recently a number of differing concepts have arisen. While the value of the original radical operation is established, the more recent modifications are not yet substantiated by proper trials.

Carcinoma, Squamous Cell↗
PubMed1975

Trans-sphenoidal hypophysectomy in disseminated carcinoma of the breast.

One hundred and eight patients with advanced carcinoma of the breast were treated by trans-sphenoidal hypophysectomy and followed up for at least 1 year. The results were assessed both by clinical response and objectively by survival following hypophysectomy, as expressed by the survival ratio. The two methods showed close correlation. The results show that there is a variation in response relating to menopausal status and age at diagnosis, subsequent hormonal manipulaton and physical condition at hypophysectomy. Younger patients whose carcinoma is diagnosed after menopause carry a good prognosis, yet the older premenopausal patients, especially if their clinical condition is poor, do not benefit. Easily available clinical information can be a guide to prognosis.

Activities of Daily Living↗