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Biomedical subjects

P E Neumann

Publications and source records attributed to P E Neumann.

68 records · Page 4Linked to original sources
PubMed1989

[Radiographic findings in edentulous alveolar ridges].

Radiographs of 5350 patients (4103 orthopantomograms, 1247 panoramics) were examined and the edentulous parts of the alveolarridges were estimated. In 1741 patients we stated 2070 pathological findings without clinical evidences. In 329 cases multiple findings were registered. Most of the cases were impacted teeth, followed by root fragments. Therapeutic measures must be decided individually. Because of the frequency of pathological x-ray-findings, diagnosis is incomplete without radiographs of the toothless jaw-parts.

Alveolar Process↗
PubMed1988

Atypical psychosis with disseminated subpial demyelination.

A 34-year-old woman experienced three episodes of an atypical psychosis, characterized by confusion, agitation, delusional thinking, paranoid ideation, and auditory hallucinations, during the 14 months prior to her death. Findings of gross examination of the brain and spinal cord were unremarkable. Histologic examination revealed scattered subpial foci of demyelination throughout the brain stem, with involvement of the hippocampal formation bilaterally. Although occasional active lesions at early stages of development were noted, most lesions were gliotic and therefore quiescent. This case and one similar example of disseminated subpial demyelination found in the literature probably represent an unusual variant of multiple sclerosis.

Adult↗
PubMed1987

Effects of triethyltin bromide on protein phosphorylation in subcellular fractions from rat and rabbit brain.

Phosphorylation of specific proteins in subcellular fractions of rat brain is affected by the presence of low concentrations (1-50 microM) of triethyltin bromide (Et3SnBr), in vitro. SDS-PAGE and autoradiography showed that Et3SnBr increased phosphorylation of an Mr = 42,000 phosphorylation of an Mr = 52,000 component. The Mr = 42,000 and 76,000-80,000 phosphoproteins have been identified as the alpha-subunit of pyruvate dehydrogenase (PDH) and synapsin, respectively. Et3SnBr-induced phosphorylation of rabbit brain PDH results in partial inactivation of the PDH complex.

Animals↗
PubMed1986

Thrombotic cerebral vasculopathy associated with herpes zoster.

We describe the clinical, radiographic, and pathological findings in 3 patients with large-vessel cerebral vasculopathy following herpes zoster. Two of the patients were studied at postmortem examination, and a brain biopsy was performed in the third. Each of the 3 patients suffered thrombotic occlusions of large vessels without notable inflammatory or granulomatous changes following trigeminal or segmental herpes zoster infection. In the 2 autopsied patients, varicella-zoster virus (VZV) antigens were detected by immunoperoxidase staining within the media of the affected cerebral arteries. Little or no inflammation was associated with the foci of the VZV antigens. These studies provide evidence that the vasculopathy following herpes zoster may result from direct VZV infection of the artery and the in situ thrombosis can develop within the infected vessels in the absence of clear inflammatory vasculitis.

Adult↗
PubMed1985

Balo's concentric sclerosis: new observations on lesion development.

A 54-year-old woman with a four-month history of progressive neurological illness was found at postmortem examination to have lesions of Balo's concentric sclerosis. Balo lesions were found in several areas scattered widely throughout the central nervous system, including the spinal cord, a previously unreported location, and were studied by histological and ultrastructural methods. Balo lesions consisted of bands of intact myelin alternating with zones of demyelination. These lesions were centered on a perivascular cuff of inflammatory cells. The center of the lesion was the oldest area with the concentric rings of demyelination decreasing in age with increasing distance from the center. The bands of intact myelin comprised mainly remyelinated fibers, were similar to those seen at the edges of chronic active multiple sclerosis plaques, and may have represented the repaired margins of preceding episodes. The occurrence of small foci of acute demyelination centered on perivascular cuffs and other changes typical of both acute and chronic active multiple sclerosis may indicate that the lesion of Balo's concentric sclerosis represents an intermediate stage in the development of an established multiple sclerosis lesion.

Central Nervous System↗
PubMed1985

Immunoreactive keratin with foreign body reaction in anencephaly.

Keratinous material, in the form of epithelial squames often with foreign body reaction and dense gliosis, was demonstrated in all of ten cases of anencephaly by a sensitive and specific immunohistochemical stain. In some cases keratin was not recognized on routine histological stains.

Anencephaly↗
PubMed1985

Primary medullary hypertensive hemorrhage.

A 33-year-old man with untreated hypertension had sudden onset of signs and symptoms suggestive of a dorsal lateral medullary syndrome. He died after 27 days. Postmortem studies revealed intramedullary hemorrhage with extension into the fourth ventricle and hypertensive cardiovascular disease.

Adult↗
PubMed1985

Fibrous bodies in growth hormone-secreting adenomas contain cytokeratin filaments.

Fibrous bodies in growth hormone-secreting adenomas were studied by immunocytochemistry using an anti-cytokeratin antiserum. Fibrous bodies are a feature of acidophil and chromophobe adenomas and are usually associated with acromegaly. Ultrastructural examination revealed round juxtanuclear filamentous aggregates, composed of 8-nm filaments and other organelles. This study demonstrated that the intermediate filaments of fibrous bodies belong to the cytokeratin class. The etiology and significance of these filamentous aggregates remain obscure.

Adenoma↗
PubMed1984

Cytoplasmic filaments of Crooke's hyaline change belong to the cytokeratin class. An immunocytochemical and ultrastructural study.

Crooke's hyaline change was studied by immunocytochemistry using an anti-adrenocorticotropic hormone (ACTH) antiserum and five different antisera against cytokeratins. Crooke's hyaline appears in basophil cells of the adenohypophysis in patients with hypercortisolism, presumably as a part of the negative feedback on corticotropin secretion. Previous studies have identified the hyaline material as a simple protein, apparently unrelated to ACTH, and electron microscopy has revealed a loss of secretory granules and an accumulation of 6-9-nm filaments in the cytoplasm of affected cells. In this study, the secretory granules in adenohypophysial cells exhibiting Crooke's hyaline change were labeled by anti-ACTH antibodies, while the hyaline material was positive for cytokeratin with each of the five antisera used. The results suggest that high levels of glucocorticoids may stimulate elaboration of cytokeratins in basophils while they suppress the production and release of ACTH.

Adenoma, Basophil↗