Should lesbians give blood?
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Blood Donors↗
Biomedical subjects
P E Hewitt
Publications and source records attributed to P E Hewitt.
Red cell alloimmunization in sickle cell disease.
Alloimmunization to red cell antigens contributes to morbidity in transfused patients. It has been recommended that blood for sickle cell patients need not be matched for antigens other than ABO and Rh(D), as there is no greater incidence of antibody production than in other multitransfused patient populations. Post transfusion alloimmunization was studied in a group of 34 sickle cell disease patients attending a U.K. haemoglobinopathy clinic. Red cell antibodies were formed in 17.6% of the transfused patients and Rhesus and Kell antibodies accounted for 66% of this total. In order to reduce alloimmunization, a policy of performing extended red cell phenotyping on the patients, and providing blood matched for Kell, and in certain circumstances the Rhesus antigens other than Rh(D), is recommended.
Adult↗
Blood donors at high risk of transmitting the acquired immune deficiency syndrome.
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Acquired Immunodeficiency Syndrome↗
CDA type I with persistent haemosiderinuria: absence of iron loading.
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Adult↗
Response to immunization with A and B human glycoproteins for the procurement of blood grouping reagents.
37 subjects have been immunized with A or B human blood group substances. All subjects showed at least a threefold increase in potency of their ABO antibodies. Use of the resulting plasma has considerably improved the quality of our ABO grouping reagents. The IgG component of these antibodies increased in all subjects and an IgA component was seen in the majority of post-immunization samples. All group O subjects developed cross-reacting anti-A,B antibodies.
ABO Blood-Group System↗
Sickle cell disease.
The sickle cell gene is present in about 10 per cent of the British black population. Thus, the diagnosis and management of all the complications of sickle cell disease are of increasing importance.
Adolescent↗
The current state of DIC.
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Disseminated Intravascular Coagulation↗
Organisation of blood transfusion services.
Worldwide, the availability of blood product support for patients varies considerably, not only in quantity and in standards but also with regard to safety from infections, and specifications for components. Similarly, the organisation responsible for providing blood varies from one country to another. This article discusses the organisation of transfusion services in the UK, describing how the blood supply is provided and looks briefly at the structure of the organisations involved.
Blood Banks↗