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Biomedical subjects

P E Groth

Publications and source records attributed to P E Groth.

12 recordsLinked to original sources
PubMed1988

Tocainide: a severe adverse reaction.

Tocainide is a primary analog of lidocaine with antiarrhythmic properties used to treat ventricular rhythm disorders. A 76-year-old man with benign paroxysmal premature ventricular contractions was treated with tocainide and developed a generalized maculopapular lupoid eruption, bleeding from the lips and gingivae, vertigo, gross tremors of the extremities, fever, and short-term memory loss, which required hospitalization. The patient recovered slowly over three months with no permanent sequelae after discontinuing the drug and receiving rigorous supportive care. His excellent physical status and absence of concomitant illness contributed to an uneventful recovery. Tocainide is a potent cardioactive drug with a long biological half-life and should be used with caution.

Aged↗
PubMed1986

Bioavailability of indomethacin tablets in men volunteers.

Indomethacin bioavailability was compared in 22 healthy men who received two tablet dosage formulations and a capsule formulation of indomethacin in a three-way crossover study. In each study period, 50 mg of the indomethacin formulation (25-mg or 50-mg tablets or 50-mg capsules) was administered as a single dose to fasting subjects. Thirteen blood samples were collected at intervals over 24 hours after each dose. Urine samples were collected for 12 hours before each dose and 48 hours after each dose. Serum indomethacin concentrations were measured by a gas chromatographic procedure. The extent of indomethacin absorption for the two tablet formulations was not significantly different from that for the reference capsule. A trend toward earlier and higher peak serum concentrations with the capsule was observed. There was less than 20% difference in mean values for area under the concentration-time curve (AUC) for the three formulations. More than 75% of the subjects had serum concentrations falling between 75 and 125% of the mean serum concentrations. The extent of absorption of indomethacin from the two tablet formulations was similar to that from the capsule.

Administration, Oral↗
PubMed1977

Drug reaction alerts.

Explore the source record for details and available documents.

Drug-Related Side Effects and Adverse Reactions↗
PubMed1975

Regional drug information service benefits: free versus fee-for-service.

Health providers in a four-state area who had utilized the Nebraska Regional Drug Information Service were surveyed to determine: (1) if providers would pay a fee for drug information services; and (2) if they would prefer a per-call fee or an annual subscription fee. Of 1,000 questionnaires mailed, approximately 500 were returned and analyzed. Results indicated that 52% of those responding felt that the drug information service provided direct benefits to patients. The service fee preferred most was $2.00 to $5.00 per call or $25.00 per year. Actual operating cost data showed that a per-call charge of $2.50 would not permit the service to break even. However, it was projected that the service would break even if it charged an annual fee of $25.00.

Costs and Cost Analysis↗