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Biomedical subjects

P Drouin

Publications and source records attributed to P Drouin.

At least 127 records · Page 7Linked to original sources
PubMed1987

Morphometric study of human hepatic cell modifications induced by fenofibrate.

We have studied liver biopsies obtained in 12 hyperlipoproteinemic (HLP) patients (type II, 6; type IV, 6) treated with diet and fenofibrate, and in 15 patients (type II, 11; type IV, 4) receiving diet only. Electron microscopy of liver biopsies and the morphometric analysis according to the method of Weibel and Rohr showed mitrochondrial changes in patients treated with fenofibrate, these changes depending on the type of hyperlipoproteinemia. In type II HLP, we found a decreased volume of normal mitochondria (fenofibrate, 125.72 +/- 17.04 X 10(-3) cm3/cm3; diet only, 185.84 +/- 8.96 10(-3), P less than .05). In type IV HLP we found a decreased number of giant mitochondria (fenofibrate, 0.08 +/- 0.03 X 10(10) cm-3; diet only, 0.32 +/- 0.08 X 10(10) cm-3, P less than .05) and a decreased volume of altered mitochondria (fenofibrate, 6.00 +/- 1.44 X 10(-3) cm3/cm3; diet only, 13.61 +/- 1.17 X 10(-3), P less than .05). In contrast with the rodent studies, the present study shows no change in the number of volume of peroxisomes.

Adult↗
PubMed1987

Stage III carcinoma of the endometrium: a review of 41 cases.

Forty-one patients with clinical-pathological stage III carcinoma of the endometrium treated between January 1958 and December 1983 at the Ottawa General Hospital were analyzed. Twenty-three patients (56%) presented with clinical stage III and 18 (44%) with pathological stage III. The 5-year survival of all stage III patients was 35%. Patients with clinical stage III had a 5-year survival of 8% compared to 70% for patients with pathological stage III (P less than 0.01). Twenty-nine patients (71%) failed. The site of first recurrence was limited to the abdominal cavity in all but 6 patients (79%). The role of whole abdominal radiation is discussed.

Adenocarcinoma↗
PubMed1987

Prognostic factors in early carcinoma of the endometrium.

Two hundred forty-one patients with clinical-pathological Stage I and 58 patients with clinical-pathological Stage II carcinoma of the endometrium treated between January 1959 and December 1983 at the Ottawa General Hospital were analyzed. The adjusted survival rate at 5 years was 92% in patients with Stage I and 66% in patients with Stage II. In patients with Stage I, the most important prognostic factors were the histological grade of the tumor and the depth of myometrial invasion. In patients with Stage II, the single most important prognostic factor was the clinical extent of the disease. Grade and depth of myometrial invasion were also significant prognostic factors, particularly in patients with pathological Stage II. Combined surgery and radiation therapy was clearly superior to surgery alone in patients with Stage II but not in patients with Stage I, although, with long-term follow-up, our results may suggest improved survival in these patients as well.

Adult↗
PubMed1987

[The flow-volume curve. Expression of emptying as a function of venous distensibility].

Mercury strain gauge venous occlusion plethysmography is a non invasive exploration of the lower limb venous hemodynamic. Classically, venous distensibility (delta V/V %) is expressed in terms of time during venous inflow (venous occlusion) and venous outflow (after cuff deflation). The authors proposed to express the total flow Q of the limb (obtained by a differentiator of the electric signal of the strain gauge) in terms of the venous distensibility (delta V/V %) whatever recording a top each second. This new representation Q = f(delta V/V) permit a more acute visualisation of the initial part of the venous emptying: more differentiation between venous drainage and systolic arterial waves, acceleration then deceleration of the venous emptying, return of the venous wall to its initial position later than venous emptying, active venous constriction. Some parameters are proposed to described this curve and the values obtained in 50 patients without and 10 patients with deep venous thrombosis are reported.

Adult↗
PubMed1986

Hypertrophy of liver peroxisomes in type II and type IV hyperlipoproteinemia.

A morphometric study on liver biopsies from patients with primary hyperlipoproteinemia (IIa n = 4, IIb n = 7, IV n = 7) and in controls (n = 7) was performed by light and electron microscopy. We found hypertrophy of peroxisomes in all subjects with hyperlipoproteinemia. As none of our patients had been given lipid-lowering drugs, this increase in volume seems to be due to hyperlipoproteinemia. Hypertrophy of peroxisomes in hyperlipoproteinemia may constitute a response of the hepatocyte to a disturbed metabolic state. Alterations of peroxisomes in hyperlipoproteinemia may thus occur prior to any lipid-lowering therapy.

Adult↗
PubMed1986

The hepatocyte and type IIA and IIB hyperlipoproteinemia. A morphometric study.

We obtained liver biopsies in 4 patients with type IIA and 7 patients with type IIB hyperlipoproteinemia, and also in 7 healthy controls. A morphometric analysis of liver tissue was carried out by light and electron microscopy. Structural alterations of the hepatocyte and its organelles in type IIA and IIB hyperlipoproteinemia seem to fall into different categories: smaller nuclei, enlarged peroxisomes and altered mitochondria are found in both types of hyperlipoproteinemia, while an increase in the volume of hepatocytes is found only in type IIA. The enlargement of liver peroxisomes in untreated hyperlipoproteinemia is noteworthy, since it has been considered as a marker of the liver toxicity of lipid-lowering drugs.

Adult↗
PubMed1986

Ultradian, circadian and circannual rhythms of blood glucose and injected insulins documented in six self-controlled adult diabetics.

The aim of the study was to document during one to two years individual rhythmic patterns in blood glucose and injected insulin in self-controlled insulin dependent (C-peptide negative) diabetics with home blood glucose monitoring. Two females and four males with diurnal activity from 0700 to 2300 self-determined their blood glucose three to six times a day over a period of 12-27 months. Circadian and ultradian rhythms were analysed for each subject on a monthly basis to document annual rhythms. Blood glucose (BG) estimated circadian acrophases were located between 2200 and 0300 for all patients and months with few exceptions. A correlation was found between circadian mesors and amplitudes of BG in four subjects. Annual changes in BG were validated for each subject with large interindividual differences in peak times. The individual mean of injected insulin (II) varied from 40 to 80 iU with annual changes validated for each subject. A group pattern was observed with a peak time either in the autumn (four patients) or in the summer (two patients). A circadian rhythm of II was detected in almost all monthly means and for all patients. Locations of computed peak time phi of II exhibited a great stability for a given individual but large interindividual differences. Thus the rather constant phi location of BG for all subjects contrasted with interindividual differences in phi locations of II. These results suggest that rhythmic changes in BG and II should be recognized when forming a realistic strategy for timing and dosing time(s) of insulin.

Activity Cycles↗
PubMed1985

Obstructive uropathy associated with endometriosis.

Although endometriosis involving the urinary tract is uncommon, it is responsible for considerable morbidity. A review of eight cases at two Ottawa teaching hospitals from 1979 to 1983 revealed obstructive uropathy in seven patients. There was permanent loss of kidney function in two, ovarian remnant syndrome in two, and patient and family history of renal disease in three. The diagnosis of endometriosis was not made before operation in four patients. Endometriosis was localized in four patients and generalized in the remaining four, while four patients had significant uterosacral nodularity. The conclusion reached after study of this small but important population is that physicians should have a heightened awareness of this uncommon but serious manifestation of the disease. Earlier diagnosis might be achieved on the basis of a high index of suspicion and careful physical and pelvic examination. The liberal use of intravenous pyelography even in cases of minimal endometriosis is urged. Intensive and prolonged follow-up of all patients with the diagnosis of endometriosis is recommended until the menopause has been reached. Treatment of obstructive uropathy requires meticulous surgical intervention and we recommend ovarian ablation with adjuvant hormonal therapy in most circumstances.

Adult↗
PubMed1984

[Action of fenofibrate in hypercholesterolemic children. 18-month follow-up].

Twelve children with lla hypercholesterolaemia were given fenofibrate and examined after 6, 12 and 18 months of treatment. Cholesterol levels were measured both in whole plasma and in lipoprotein fractions after precipitation with concanavalin A. Plasma cholesterol and apoprotein B-bound cholesterol were reduced by 20% and 26% respectively (p less than 0.01). A non-significant 10% increase in apoprotein A-bound cholesterol was observed. These changes were effective at 6 months and persisted throughout the study. Fenofibrate was well tolerated and this, together with its effectiveness in lowering lipid values in hypercholesterolaemic children, suggests that it would be useful to achieve primary prevention.

Child↗
PubMed1984

28-hour profiles of blood glucose (BG), plasma immunoreactive insulin (IRI) and IRI/BG ratio in four insulinomas.

Nycthemeral variations in blood glucose (BG) and insulinemia (IRI) of four subjects with insulin-secreting pancreatic tumors were determined. Blood samples were drawn every 15 min over a 28-h period. After surgery, two of the subjects were retested. Meals were distributed during testing so that there was a minimum of eight meals per test. The meals before and after surgery were qualitatively, quantitatively and chronologically the same. Even though the circadian profiles of the glycemia and insulinemia varied greatly among the subjects, there were three common characteristics during the noctural period (24 h-8 h): Existence of one or several phases of at least 1 hour where the glycemia was less than 2.78 mmol/l, Existence of IRI peaks, without eating. Existence of a peak or of increased values (as compared to normal values) of the IRI/BG ratio, without eating. The IRI/BG ratio is a very sensitive index for insulin secretion dysfunction as compared to glycemia. The results suggest that the measurement of glycemia and insulinemia of sleeping subjects and then calculation of the IRI/BG ratio is sufficient to affirm the presence of an insulin-secreting adenoma.

Adenoma, Islet Cell↗