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Biomedical subjects

P Dreyfus

Publications and source records attributed to P Dreyfus.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Rheumatological manifestations of adrenal insufficiencies].

Muscular, articular and periarticular symptoms were reviewed in 19 patients with adrenal failure and compared with previously published data. Symptoms are variable and non-specific; muscular cramps and periarticular calcification were common. Hypercalcaemia was uncommon but its incidence was probably underestimated. Calcification of the ear cartilage was rare but characteristic.

Adrenal Insufficiency↗
PubMed1984

Distribution and quantification of ACh receptors and innervation in diaphragm muscle of normal and mdg mouse embryos.

Muscular dysgenesis (mdg) in the mouse is an autosomal recessive mutation, expressed in the homozygous state (in vivo and in vitro) as an absence of skeletal muscle contraction. The distribution of acetylcholine receptors (ACh R) in the diaphragms of phenotypically normal and dysgenic (mdg/mdg) embryos was studied from the 14th to 19th day of gestation by binding of 125I-alpha-bungarotoxin to the muscle, followed by autoradiography of longitudinally sectioned hemidiaphragms and/or of isolated muscle fibers. Localization of ACh R at putative motor end-plate regions begins 14 to 15 days in utero in both normal and dysgenic diaphragms. The distribution of high ACh R density patches is aberrantly scattered beyond the normal innervation pattern in dysgenic diaphragms. Isolated mutant fibers possess (1) multiple ACh R clusters, up to five per single fiber, (2) larger clusters of more variable morphology and variable receptor density than normal clusters, and (3) higher levels of extrajunctional receptors than normal fibers. These autoradiographic results correlate well with higher total level of toxin binding sites per diaphragm and per milligram protein in dysgenic vs normal muscle, as quantified from gamma counting of sucrose density gradient isolation of 125I-toxin-ACh R complexes. The dispersed distribution of ACh R patches on dysgenic muscle may be correlated with extensive phrenic nerve branching as demonstrated by silver impregnation technique. We suggest that the aberrant ACh R cluster distribution is a result of multiple innervation of single fibers from the branched nerve terminals. Possible causes of the excessive nerve branching in the mutant are discussed in light of generalized nerve sprouting found in paralyzed muscle.

Animals↗
PubMed1984

[Cross reactions of HLA A and B antigens in 63 patients with rheumatoid arthritis].

Cross reactions are very frequently observed when HLA A and B antigens are determined by a routine lymphocytotoxicity method. Such cross reactions are probably due to biochemical structural similarities shared by several HLA antigens. In this work, we studied the cross reactions which occurred during HLA A and B typing of 63 patients with classical or definite rheumatoid arthritis (RA) according to the ARA criteria. No association was found between RA and any single HLA A or B antigen. In contrast, when cross reactions were taken into account, the B8 B14 cross reactant group frequency was increased in RA patients (34,9 p. cent) as compared to controls (20 p. cent, p less than 0,004) and was even more clearly elevated in the 42 seropositive RA patients (40,5 p. cent, p less than 0,002). No relation was found between HLA phenotype and Sjögren's syndrome even when cross reactions were considered. The B8 DR3 haplotype has been shown to be associated with drug intolerance . The B8 B14 cross reactant group was present in 22 out of our 63 RA patients, 16 of whom were B8+. Among the latter, 6 patients exhibited poor tolerance to gold salts and 6 other patients did not respond to gold therapy, suggesting that the B8 antigen could predict not only a poor tolerance but also a poor response to disease modifying drugs.

Arthritis, Rheumatoid↗
PubMed1984

[Study of HLA antigens A and B and their cross reactions in B27-negative ankylosing spondylarthritis].

In an attempt to find common immunogenetic features in B27+ and B27- ankylosing spondylitis patients, the B7 cross reactant antigens (BW22, B27, B40, B12, B13) were systematically tested by a lymphocytotoxicity method in 43 patients suffering from ankylosing spondylitis according to the Rome criteria. These included 25 caucasian patients (20 B27+, 5 B27-), 15 north african patients (11 B27+, 4 B27-) and 3 west indian mulattos (all B27-). The frequency of the B7 cross reactant antigens, when compared to controls, was not increased in the B27- patients as a whole, nor in any of the 3 populations studied. Our negative results are in agreement with those of similar published studies in homogeneous populations. They do not support the hypothesis of a direct involvement of HLA B antigens as cofactors favouring ankylosing spondylitis.

Cross Reactions↗
PubMed1981

[Sea urchin spines synovitis. A case report with positive pasteurellosis antigen intradermoreaction (author's transl)].

A case is reported of a 53 years old woman who injured proximal interphalangeal joint of the right fourth finger on a sea urchin spine. She developed an extensive arthritis after synovial biopsy with sequellar fourth and fifth paw fashioned fingers and a palmar fibrositis. The originality of this observation with typical clinical symptoms and characteristic synovial histology (giant cells granulomatous synovitis) is the combination of a pasteurellosis infection. The diagnosis of the last one can be based on the inoculation in extra-aquatic condition, the extension of arthritis and particularly the positivity of pasteurellosis antigen intradermoreaction.

Arthritis, Infectious↗
PubMed1978

The effect of high doses of vitamin B6 on autistic children: a double-blind crossover study.

The authors used data from an earlier nonblind study to identify 16 autistic-type child outpatients who had apparently improved when given vitamin B6 (pyridoxine). In a double-blind study each child's B6 supplement was replaced during two separate experimental trial periods with either a B6 supplement or a matched placebo. Behavior was rated as deteriorating significantly during the B6 withdrawal.

Adolescent↗