Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study
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Journal Article↗
Biomedical subjects
P Donshik
Publications and source records attributed to P Donshik.
Ligneous conjunctivitis with ear involvement.
We report the association of ligneous conjunctivitis with middle-ear and tympanic membrane involvement in two children. Eye and ear specimens revealed histopathologic and ultrastructural findings consistent with ligneous conjunctivitis, characterized by an amorphous, eosinophilic material with acute and chronic nongranulomatous inflammation. Ear specimens demonstrated granulation tissue along with the above features. Conjunctival and ear lesions from these patients were studied histochemically, immunohistochemically, and ultrastructurally. Our studies demonstrate fibrin and albumin deposition as a common feature in all lesions. Deposition of other components, such as mucopolysaccharides, amyloid, immunoglobulins, and mast cells, were, however, variable. The diversified nature of these lesions, together with the association of eye and ear disease, substantiates the existence of an underlying systemic disorder of unknown cause.
Amyloid↗
Pollen-specific IgG antibodies in the tears of patients with allergic-like conjunctivitis.
Specific-IgG antibodies to rye grass and/or AgE in the tear secretions were demonstrated in studies of patients with the clinical features of allergic conjunctivitis but negative immediate skin reactivity and absent IgE antibodies by RAST to the inhalant pollen allergens. Studies by use of transferrin as a marker for the vascular leakage of plasma proteins into the tear secretions indicated that more than 98% of these pollen-specific IgG antibodies were locally produced by the conjunctival tissues of the external eye. These findings suggest that IgG-mediated immune mechanism(s) are important in the pathogenesis of some patients with allergic-like conjunctivitis.
Adolescent↗
Treatment of chronic staphylococcal blepharoconjunctivitis with a new topical steroid anti-infective ophthalmic solution.
Gentamicin sulfate and betamethasone phosphate were combined in solution form for topical ophthalmic use in patients with chronic staphylococcal blepharoconjunctivitis. The study involved 79 patients and was a two-week double-blind placebo controlled trial comparing the combination with its individual components and placebo. Lid cultures showed that the combination and gentamicin were significantly superior to placebo or betamethasone in freeing the lids of staphylococcus. In addition, the patients treated with either the combination or betamethasone showed greater improvement in the total objective signs than those patients treated with either gentamicin or placebo at the first follow-up visit. No drug-related adverse reactions occurred in the combination treatment group.
Administration, Topical↗
Disposable hydrogel contact lenses for extended wear.
Nine ophthalmologists and nine optometrists conducted a premarket study of the Acuvue disposable contact lens manufactured by Vistakon, Inc. Of the 812 patients offered the lens, 733 accepted it and were enrolled in the study. These patients were fitted with the lens and followed for a period of 8 months. Over 98% of these patients had 20/25 or better vision on initial fitting; and subjective ratings of lens comfort were very good. Only 3.7% (27 of 733) discontinued wearing their lenses during the study period. Thirty-four patients (5.6%) experienced a problem while wearing their contact lenses.
Adolescent↗