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Biomedical subjects

P Dobson

Publications and source records attributed to P Dobson.

9 recordsLinked to original sources
PubMed1986

Arthroscopic synovectomy: a prospective study.

Seven patients undergoing arthroscopic synovectomy for painful knee joint synovitis with marked synovial swelling were assessed preoperatively and up to 24 months postoperatively. Six patients had rheumatoid arthritis and one psoriatic arthritis. Patients were assessed for overall disease activity and indices of synovitis and function of the knees. There was minimal or no loss of function in the operated knee at one month. Subsequent improvement was reflected in reduction of pain on walking, pain on using steps, and swelling of the knee, with improvement occurring up to 6 months and maintained at 24 months. No sustained loss of movement was observed in the operated knee and all patients had improvement in knee flexion at 24 months. Patients universally regarded the procedure as worthwhile. These results highlight the lesser morbidity of arthroscopic synovectomy compared to that known to be associated with open synovectomy. Further study is required to evaluate the longterm value of this procedure.

Adult↗
PubMed1979

Immunological specificity of natural opsonins and their role in the cross-reactivity between Staphylococcus aureus Mardi and Escherichia coli 101.

The immunochemical specificity of the observed cross-reactivity between Escherichia coli strain 101 and Staphylococcus aureus strain Mardi was examined. The cross-reactivity was shown to be dependent upon mucopeptide antibodies which are present in normal and immune sera. Although both organisms contained surface antigens with immunodominant glucuronic acid residues, in vitro phagocytosis studies indicated that antibodies directed against these antigens were not significantly involved in the opsonization process. Rather, antibodies with mucopeptide specificity were shown to be involved in the in vitro phagocytosis of these organisms by polymorphonuclear leukocytes. The mucopeptide antibodies, which were found in both nonimmune and immune sera, were shown to be effective in opsonizing both the S. aureus strain and the E. coli strain. The ubiquitous distribution of E. coli strains containing mucopeptide antigens common to most bacteria suggests that these organisms may be responsible for the wide prevalence of natural staphylococcal opsonins with mucopeptide specificity in normal sera.

Antibodies, Bacterial↗