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Biomedical subjects

P Dickens

Publications and source records attributed to P Dickens.

42 records · Page 3Linked to original sources
PubMedDate not supplied

Sudden death associated with cardiac inflammatory pseudotumour.

We report a case of cardiac inflammatory pseudotumour which we believe caused sudden death in a previously healthy 55-year-old Chinese female. The features of inflammatory pseudotumours are briefly reviewed. Cardiac lesions are very rare, have only been reported in children before, and have not been associated with sudden death.

Death, Sudden↗
PubMedDate not supplied

Metabolism of arachidonic acid in the aorta of spontaneously hypertensive rats.

1. The metabolism of [14C]-arachidonic acid has been studied in isolated aortae from age-matched spontaneously hypertensive (SH) rats and their normotensive Wistar Kyoto (WK) controls. 2. High pressure liquid chromatography of extracts of the incubation mixture from both SH and WK rats revealed the presence of 6-oxo-prostaglandin F1 alpha, the hydration product of prostacyclin, and a single, broad peak of unknown metabolites. No thromboxane B2, or prostaglandins E2 of F2 alpha could be detected in aortic incubations. 3. The SH rats produced significantly more 6-oxo-prostaglandin F1 alpha than the WK rats, but there was no difference between the strains in the proportion of label appearing in the unknown peak of the chromatograms. 4. These data confirm that vascular tissue of SH rats has enhanced ability to transform arachidonic acid into prostacyclin. Induction of these enzymes may be an adaptive response to elevated blood pressure, but the mechanism of this effect has yet to be elucidated.

Animals↗