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Biomedical subjects

P Dhar

Publications and source records attributed to P Dhar.

At least 55 records · Page 3Linked to original sources
PubMed1996

Evaluation of latex agglutination test for rapid detection of goat poxvirus antigen and antibodies.

Soluble antigen fraction of goat poxvirus (GPV) separated from infectious viral particles by ultracentrifugation of skin scab suspensions prepared from experimentally infected goats was employed for the first time to diagnose goat pox. The antiserum raised against this fraction was found to be specific and not reactive with healthy goat skin extracts. Subsequently, a latex agglutination (LA) test has been developed and standardized for the rapid detection of GPV antigen or antibody in skin scab suspensions or serum samples, respectively. In comparison to the counter immunoelectrophoresis (CIE) test the LA test was more sensitive in the detection of GPV antibodies, but equally sensitive in the detection of GPV antigen. The LA test can be taken for a simple and quick diagnostic tool for primary screening of goat pox.

Agglutination Tests↗
PubMed1996

Current trends in the diagnosis and management of cystic hydatid disease of the liver.

Cystic hydatid disease caused by Echinococcus granulosus most commonly involves the liver. Recent years have seen many changes in modalities of diagnosis and treatment of cystic disease in the liver. Currently used methods of immunodiagnosis, newer radiological modes of imaging, emerging non-surgical techniques of management and the impact of minimal access surgery in this disease are highlighted in the present review.

Animals↗
PubMed1995

Humoral antibody response in animals infected with virulent rinderpest virus.

Humoral antibody responses in cattle or rabbits infected with virulent rinderpest virus or lapinised rinderpest virus respectively were assessed. Rinderpest specific antibodies could be first detected 6 days post-infection. No correlation could be established between antibody response and the course of the disease in infected animals during the early stages of infection. The animals with fatal infection either did not respond or had a transient antibody response. A gradual increase in antibody titre from 7 days post-infection was observed in animals which ultimately recovered.

Animals↗
PubMed1992

Hypokalaemic paralysis in malnourished children.

Six malnourished children presenting with acute flaccid paralysis caused by hypokalaemia are described. Their ages ranged from 6 to 36 months. The extent of paralysis varied from neck flop to quadriparesis. Two cases had respiratory paralysis requiring ventilatory support for 48-72 hours. All were successfully treated with potassium supplementation. Hypokalaemia should be considered in the differential diagnosis of acute flaccid paralysis in malnourished children.

Acute Disease↗
PubMed1991

Preliminary observation on drug resistant cases of typhoid fever.

We report here a sudden and marked increase in the occurrence, in a captive population, of typhoid fever cases showing multiple drug resistance. Fifty one cases of typhoid fever were seen from January '90 to June '90 of which 49% showed multiple drug resistance. Comparative figures for resistance in the previous three years were 0% (1987), 5% (1988), 14% (1989). Shared resistance to chloramphenicol, ampicillin, amoxycillin and sensitivity to gentamicin, kanamycin, sisomycin, cephazolin, norfloxacin and ciprofloxacin in most of our cases suggest infection by a common strain with R-factor, mediated resistance. The illness was prolonged and associated with serious complications. Therapy with combination of quinolone derivatives and aminoglycoside antibiotics seemed justified on the basis of the in-vitro tests and clinical response. Efforts to identify the strain and stern public health measures to prevent further development of drug resistant S typhi are urgently indicated.

Chloramphenicol Resistance↗
PubMedDate not supplied

Elective surgery for corrosive-induced gastric injury.

Gastric cicatrization is a well recognized late sequela of corrosive gastric injury, but the optimum timing and type of surgery for this complication are still unclear. Over a 7-year period (1988-1994) 34 patients underwent elective surgery for gastric lesions secondary to corrosive ingestion. A total of 18 (53%) patients had an associated esophageal stricture and presented with dysphagia, 15 (44%) patients had features of gastric outlet obstruction, 6 (18%) had diffuse gastric injury, and 28 (82%) had a segmental lesion. A tube jejunostomy was done in 23 (68%) patients to improve nutrition and resulted in a significant increase in weight and in the serum protein level after 8 weeks of tube feeding. Elective surgery was performed 3 to 24 months (average 7 months) after ingestion of the corrosive substance. Gastric resection was done in 20 (59%) patients and gastrojejunostomy (without vagotomy) in 11 (32%); at follow-up the latter group did not exhibit development of a stomal ulcer. In patients with an associated esophageal stricture, endoscopic dilatation was successful in 89% patients and simplified the surgical approach. In conclusion, the success of surgery for corrosive-induced gastric injury depends on selecting the right procedure and intervening at the appropriate time.

Acids↗