Fine needle aspiration cytology of metastatic apocrine carcinoma.
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Biomedical subjects
Publications and source records attributed to P Dey.
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Thirty-five patients with orbital and eyelid lesions were subjected to fine needle aspiration biopsy (FNAB). Histopathology or other investigations were available in 18 cases; in 17 cases (94%) a concordant diagnosis was reached. There was one false-positive diagnosis in 18 cases (5.5%). FNAB is a reliable and safe diagnostic technique and can be used routinely in outpatient departments for the diagnosis of orbital lesions. It is particularly useful in nonresectable and retrobulbar orbital lesions.
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One hundred five cases of tuberculosis of the abdomen (excluding genitourinary involvement) diagnosed initially by fine needle aspiration cytology between 1988 and 1991 were analyzed retrospectively. The diagnosis of tuberculosis was suspected clinically in 60% of the cases prior to aspiration. The anatomic locations of the lesions were ileocecal in 69 cases, lymph node in 18, colon in 10, jejunoileal in 2, duodenojejunal in 1, peritoneal in 1 and liver in 4. Cytomorphologic analysis of the aspirates from these 105 cases showed only necrotic material in 19 cases, necrotic material with epithelioid granuloma in 36 cases and epithelioid granuloma without necrosis in 50 cases. Ziehl-Neelsen staining for acid-fast bacilli was positive in 47 of 105 cases (45%). Cultures for mycobacteria were positive in 5 of 24 cases. Histologic confirmation was available in five cases only. The cytodiagnosis correlated well with the radiologic findings and response to antituberculosis chemotherapy.
Microfilariae of Wuchereria bancrofti were detected by fine needle aspiration biopsy (FNAB) in an axillary lymph node from a 27-year-old female. The patient also had intestinal tuberculosis. A routine hemogram did not show any eosinophilia, and three consecutive night blood samples also were negative for microfilariae. This was an early case of filariasis without microfilaremia and was detected by FNAB of the lymph node. The association of filariasis and tuberculosis was purely coincidental.
We reviewed the cytomorphologic features of fine needle aspiration biopsy (FNAB) smears from 15 cases of renal, extrarenal and metastatic Wilms' tumor. The findings were correlated with the histopathologic features. In cytology smears, blastemal cells were recognized in all cases. The following cell types were seen: epithelial cells, 60%; stromal component, 33.3%; tubular differentiation, 26.6%; and glomeruloid differentiation, 33.3%. FNAB smears of the metastatic lesions in the liver and of the primary lesions did not reveal any significant difference in cellular composition. Subcutaneous soft tissue metastasis from an anaplastic Wilms' tumor showed marked anaplasia and pleomorphism of blastemal cells along with frequent mitosis and bizarre tumor giant cells. Extrarenal Wilms' tumor showed only blastemal cells, though histopathology showed the classic triphasic pattern along with skeletal muscle differentiation. There were no complications attributable to the procedure. Recognition of these cellular components in FNAB smears will help in establishing an FNAB diagnosis of Wilms' tumor, particularly when preoperative chemotherapy is needed.
Fine needle aspiration cytology of one case each of chondroid syringoma and syringocystadenoma papilliferum with histopathologic confirmation are reported. The aspirate of chondroid syringoma was characterized by the presence of two distinct components, a mesenchymal element with a chondroid appearance and an epithelial component. The chondroid element predominated in the smears. The aspirate from syringocystadenoma papilliferum showed papillalike clusters and dyshesive, monomorphic epithelial cells in a background of inflammatory cells. The clinical diagnosis and differential cytodiagnoses are discussed.
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