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Biomedical subjects

P Devos

Publications and source records attributed to P Devos.

At least 109 records · Page 6Linked to original sources
PubMed1982

[Primary neuromeningeal manifestation, isolated for a long period, of acute lymphoblastic leukemia].

The course of acute leukaemias, particularly of the lymphoblastic type, is very frequently complicated by the development of neuromeningeal localisations of the disease. They may, more rarely, be presenting initial lesions, their origin being confirmed clinically and/or biologically, but it is exceptional that they remain a strictly isolated expression of the affection. A case is reported of a 16-year-old adolescent with leukaemic meningitis, in whom haematological tests (blood counts, bone marrow smear, iliac medullary biopsy, lymph node biopsy) gave negative results over a period of at least two months. Based on the findings in this case, the significance of early neuromeningeal localisations of acute leukaemias is discussed.

Adolescent↗
PubMed1982

[Sub, retro- and supracerebellar arachnoid cysts and pseudocyts in adults. Six observations].

Four arachnoïd cysts and two arachnoïd communicating pouchs in sub, retro and supra cerebellar situation are presented. These formations are rarely encountered in adults and distinction is often difficult from other cystic lesions whose structure is different (neuroglial and ependymal cysts). Intellectual slowing, mild ataxia or urinary disturbances, related to chronic hydrocephalus may be the only clinical symptoms. After computed tomography, isotopic cysternography, rather than metrizamide cysternography, must precise the possible communication between the cystic pouch and the subarachnoïd spaces, and the possible ventricular reflux. These informations are mandatory before selecting the treatment. In case of a non communicating cyst, total or subtotal excision should be preferred.

Adolescent↗
PubMed1981

Tc-99m-pertechnetate scanning in metastatic thyroid carcinoma: a case report.

Radionuclide imaging with Tc-99m-pertechnetate in a patient with a mixed papillary-follicular carcinoma of the thyroid gland showed evidence of increased radioactivity at sites of functioning metastases. The use of Tc-99m-pertechnetate as well as I-131 for imaging in search of functioning thyroid metastases is discussed.

Adenocarcinoma↗
PubMed1980

Random, presumably hydrolytic, and lysosomal glycogenolysis in the livers of rats treated with phlorizin and of newborn rats.

1. The glycogen formed in the livers of adult rats was labelled by injection of [1-14C] galactose soon after initiation of re-feeding after starvation. The rats were anaesthetized 4h later and glycogenolysis was induced by giving them a mixture of glucagon and insulin. In confirmation of previous work [Devos & Hers (1979) Eur J. Biochem. 99, 161-167],, there was a delay in degradation of the labelled glycogen by comparison with total glycogen. This pattern is considered as characteristic of an ordered glycogenolysis. Treatment of rats with phlorizin abolished the difference between the fate of labelled and total glycogen, causing, therefore, a random glycogenolysis. 2. Foetal liver glycogen was made radioactive by injecting [14C] glucose into the mother at the 19.5 day of gestation, i.e. at the time when this glycogen starts to be synthesized. During the postnatal degradation of this glycogen, radioactive and total glycogen were degraded at approximately the same rate, indicating that glycogenolysis occurred at random. In contrast, when puromycin was injected into the newborn rats, there was a delay in he degradation of the labelled glycogen as compared with that of total glycogen, as currently observed in the normal adult liver. 3. These data are discussed in relation with the fact that glycogen-filled vacuoles are currently seen in the livers of adult rats treated with phlorizin, and also in the neonatal livers, and that puromycin is known to cause the disappearance of these autophagic pictures in the liver of newborn rats. It is suggested that random glycogenolysis occurs through hydrolysis by the lysosomal acid alpha-glucosidase, in the course of autophagy.

Animals↗
PubMed1980

Reflections on the etiology of hot spots on liver scans.

Liver scintigraphy demonstrated areas of increased radiocolloid uptake in three cases with obstruction of the superior vena cava and extensive collateral circulation through the veins of the thoracic wall. The pattern of the hyperactive zones is indicative of predominant vascularization of the liver via the umbilical vein, with high colloid particle deposition in the quadrate lobe and adjacent part of the right lobe. These liver regions vascularized by the first intrahepatic branches of the umbilical vein as demonstrated by postmortem angiography, probably extract a great portion of the tracer dose, resulting in localized hyperactivity. An identical liver scan image was, however, found in a fourth case without evident superior vena cava syndrome. In this patient, presenting with a bronchus carcinoma with paratracheal metastatic lymph nodes, there is no explanation metastatic lymph nodes, there is no explanation (collateral circulation without vena cava obstruction?) for the abnormal tracer distribution within the liver.

Adult↗
PubMed1978

Comparison of 133Xe washout curves after bolus inhalation, perfusion, and equilibration.

In 6 healthy subjects and 13 patients with chronic obstructive lung disease, 133Xe washout curves after bolus inhalation, perfusion and equilibration were compared, using a gamma camera and computerized data handling. In healthy subjects the washout after equilibration was significantly slower than after the two other procedures. As this phenomenon occurred at the basal zones, it was attributed to the presence of airway closure in some units. In patients, the three washouts were significantly different from each other. This indicated the existence of intraregional inhomogeneity in ventilation, perfusion and ventilation-perfusion ratio. Our conclusion is that comparison of these different washout methods yields valuable information not only on absolute values of pulmonary function but also on the intraregional distribution, which cannot be obtained by other examinations.

Adult↗
PubMed1976

A morphologic and biochemical study of the fate of antibody-bearing liposomes.

The effect of the intravenous administration of gamma-globulins, entrapped or not within liposomes, was investigated in rodent liver. Desialation of gamma-globulins did not influence significantly their uptake by this organ. Fluorescein-labeled nonspecific gamma-globulins and antibodies raised against the lysosomal acid alpha-glucosidase were entrapped within two types of liposomes. The administration of negatively charged liposomes made of lecithin, cholesterol, and dicetylphosphate was badly tolerated. Positively charged liposomes, in which dicetylphosphate was replaced by stearylamine, allowed a considerably higher yield of entrapment and were well tolerated by the animals. Approximately half of the fluorescent gamma-globulins were recovered in the liver, and evidence is presented for the intralysosomal localization of positively charged liposomes, both in the reticuloendothelial cells and in the hepatocytes. A striking difference exists, nevertheless, in the appearance of the two types of cells, 1 hour and 7 1/2 hours after injection. The specific antibodies never inhibited more than 50% of the activity of liver acid alpha-glucosidase, and there was no significant modification in the glycogen content of this organ. This work points to the influence of the composition of liposomes, in determining the entrapment of proteins, the toxicity, the uptake by the liver, and the distribution of these lipidic spherules in the different types of cells. This factor will have to be taken into account if liposomes are to be used as vectors in the treatment of lysosomal storage diseases.

Animals↗
PubMed1974

Glycogen metabolism in the liver of the foetal rat.

1. The glycogen present in the liver of rat foetuses was labelled by injecting a trace amount of [6-(3)H]glucose into the mother at 19.5 days of gestation. The radioactivity incorporated in the glycogen 4h after the administration of the label was still present 38h later. A large proportion of this radioactivity was on the outer chains of the polysaccharide. These results indicate that there is normally almost no glycogen degradation in the foetal liver. In contrast, glycogen breakdown occurs very rapidly in the livers of foetuses whose mother is anaesthetized. 2. Glycogen synthetase is present in the liver at day 16 of gestation at a concentration as high as 30% of that in the adult, but essentially as an inactive (b) enzyme. The appearance of synthetase phosphatase between days 18 and 19 corresponds to that of synthetase a and to the beginning of glycogen synthesis. From day 19 to 21.5 the amount of synthetase a present in the foetal liver is just sufficient to account for the actual rate of glycogen deposition. 3. The content of total phosphorylase in the foetal liver increases continuously from day 16 to birth. However, a precise measurement of the a and b forms of the enzyme in the liver of non-anaesthetized foetuses is not possible. Taking the rate of glycogenolysis as an appropriate index of phosphorylase activity, we conclude that this enzyme is almost entirely in the inactive form in the foetal liver under normal conditions. 4. The accumulation of glycogen in the liver during late pregnancy may therefore be explained by a relatively slow rate of synthesis and a nearly total absence of degradation.

Animals↗