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Biomedical subjects

P Derome

Publications and source records attributed to P Derome.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Neurosurgical indications in craniofacial injuries].

The cerebral complications of cranio-facial trauma require urgent neurosurgical assessment and intervention. Apart from such cases, the cooperation of the neurosurgeon is also necessary when the anterior part of the base of the skull must be explored. This may be necessary either in the presence of a cerebrospinal fluid leak with rhinorrhoea or because the reduction and fixation of orbito-facial fractures requires an intracranial approach. Early treatment, at the same time, of all cranial, basal and orbito-facial lesions is recommended.

Brain↗
PubMedDate not supplied

[Clinical use of nitroglycerin as an hypotensive agent during general anesthesia (author's transl)].

Nitroglycerine has a direct vasodilating action on both venous and arterial smooth muscle fibers. On account of this, it has been used as hypotensive agent, in aqueous solution, on 22 surgical patients, 10 of them in neurosurgery. The total doses used were 0.76 +/- 0.12 mg/kg during 94 +/- 30 minutes (rate = 8.1 microgram/kg/min). Nitroglycerine induces a rapid onset of hypotension (3 to 4 min), spontaneously reversible in 27 +/- 8 minutes after the arrest of the infusion. The mean drop in mean arterial blood pressure achieved has been 34 p. cent. It is accompanied by a 67 +/- 9 p. cent fall of filling pressures and a fall 13 +/- 4 p. cent of cardiac index, without modification of the heart rate. Tachyphylaxis was noted 15 +/- 6 minutes following nitroglycerine infusion at rate lower than 2 microgram/kg/min, but not when the rate was above 10 microgram/kg/min. Therefore, if the drug is used to achieve controlled hypotension, high doses are necessary. No signs of toxicity were noted. In 4 cases, other hypotensive agents had been used to bring the mean arterial blood pressure below 50 Torr, which could not be achieved with nitroglycerine alone.

Adolescent↗