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Biomedical subjects

P Delmas

Publications and source records attributed to P Delmas.

106 records · Page 6Linked to original sources

[Prolonged parenteral nutrition in pediatrics: technics and indications].

Prolonged parenteral nutrition is an indispensable technique in a number of gastro-intestinal and non-gastro-intestinal indications in the field of paediatrics. The catheter should be placed in the superior vena cava either percutaneously or surgically. The maintenance of the infusion line, the dressings and the monitoring of the child should be conducted by a specialised nursing team. The carbohydrate and protein nutrients are prepared in the pharmacy and should be adapted daily. The complexity of this technique requires a close collaboration between physicians, surgeons, pharmacists and biochemists. The iatrogenic and metabolic complications may be multiple and severe, but can be reduced to a minimum by a rigorous methodology.

Humans↗

[The surgical form of the hemolytic-uremic syndrome].

The hemolytic-uremic syndrome consist of micro-angiopathic hemolytic anemia, acute renal failure, and thrombocytopenia following a prodromal illness of gastroenteritis. The syndrome can present in dramatic fashion with severe abdominal pain and signs of peritonitis suggesting an acute surgical crisis. In some cases, laparotomy is necessary, and we report a case with colectomy.

Adolescent↗

[Dorsal extradural hourglass lipoma in children].

The authors would like to recount and discuss the case of a 14 months old child which presented a dumbbell dorsal lipoma, purely extradural with no congenital anomalies. The warning signal was the discovery of paraparesis with the regression of walking ability. The hypothesis of medullary compression by a dumbbell dorsal tumor was quickly dismissed with the discovery of a mediastinal mass on the pulmonary X-Ray. A diagnosis of the pre-operational neuroblastoma was carried out because of detection of dorsal epidural medullary compression revealed by the myelography. The testing was completed with a vertebral computed tomography, which clearly showed the extent of medullar compression, and the mediastinal tumoral development under the paravertebral muscular masses. The child was operated on at 2 fronts, vertebrally and thoraxically for an encapsulated, perfectly separable and non hemorrhaging tumor. The anatomopathological examination confirmed the diagnosis of the lipoma. It is in the resumption of the computed tomographic examination that the tumoral density measures will confirm fatty tissue with numbers of density--50. In light of the literature, we are discussing the appearance of the lipoma, entirely exceptional because of its dorsal location, its extradural and certainly its dumbbell position, with large thoraxic development. It is necessary to stress the importance of the meticulous neurological examination of the child, the diagnostical necessity of the CT scan and the importance of the avoidance of the creation of an instable vertebral lesion at the time of laminotomy. In this case only the early double surgical operation permitted the recovery of the child.

Epidural Space↗

[GLA-protein of bone. Physiologic factor and new biological marker in bone pathology].

The gamma-carboxyglutamic acid-containing protein (GLA-protein) present in bone has strong affinity for hydroxyapatite crystals and its synthesis is vitamin D-dependent, which suggests that it might play a major role in bone physiology. It is also the first sensitive and specific marker of bone tissue remodelling. Usefulness of GLA-protein determinations in the diagnosis and therapeutic monitoring of bone diseases remains to be demonstrated by further studies.

Animals↗

[Dichloromethylene diphosphonate (Cl2MDP) treatment of hypercalcaemia produced from bone metastases (author's transl)].

Cl2MDP, a potent inhibitor of osteoclast-mediated bone resorption, was tested in 8 patients with malignant hypercalcaemia. In a 2 months' double-blind, cross-over study the patients received Cl2MDP (3200 mg/day) during 4 weeks and a placebo during 4 weeks in a randomized sequence. The serum Ca level fell from a mean pre-trial value of 12.2 +/- 1.7 mg/dl to 10.3 +/- 1.4 mg/dl after 4 weeks of Cl2MDP (p = 0.01). Reduction was rapid, with a mean serum Ca value of 10.5 +/- 1.4 mg/dl as early as the 3rd day. At the end of the Cl2MDP treatment, 6 out of the 8 patients had normal serum Ca levels. Following active treatment, the serum Ca level significantly increased in 2 patients and remained low in one patient under placebo. Treatment with Cl2MDP resulted in a decrease in calciuria from 397 +/- 193 mg/g creatinine/24 hours to 241 +/- 211 mg/g creatinine/24 hours (p = 0.05), but there was no decrease in hydroxyproline. Serum phosphorus and PTH levels remained normal. It is concluded that Cl2MDP is an effective and convenient oral treatment of hypercalcaemia due to bone metastases.

Adult↗

[Osteoporosis in Klinefelter's syndrome Quantitative bone histological data in 5 cases and relationship with hormonal deficiency (author's transl)].

The histomorphometric data obtained from nondecalcified iliac bone biopsies in 5 patients with Klinefelter's syndrome (KS), low back pain and histologically confirmed osteoporosis are presented. The data were compared with those of 3 other patients with osteoporosis and hypogonadism unconnected with KS. The results were identical in both groups, with rarefied spongy bone and strongly depressed osteoblastic activity, the latter being expressed morphologically by a decrease in osteoid seam thickness and dynamically by a low appositional rate. As both groups had low androgen levels, it is suggested that bone rarefaction in KS is associated with the hormonal deficiency and not directly due to the chromosomal abnormality. T e mechanism of action of androgens on bone tissue is discussed.

Adult↗

[Peritoneal pseudocyst, a rare complication of ventriculoperitoneal shunt (case report) (author's transl)].

The authors report an observation of peritoneal pseudocyst, complication of a ventriculoperitoneal shunt in a six month infant hydrocephalus, with spinal bifida. The literature review confirms the rarity of that complication (25 observations), always preceded by incidents of the shunt function, be it mechanical or infection. The pathogeny remains mysterious. It is probably a peritoneal reaction to infectious problems or stranger body reject. In therapeutic, except the evacuation of the pseudocyst by puncture or drainage by laparotomy, you must change the shunt utilizing the ventriculo-atrial shunt. It is necessary to keep obsession of an often latent infection that compels an external drain unit suitable antibiotics.

Cerebrospinal Fluid Shunts↗

Biologic, histologic and densitometric effects of oral risedronate on bone in patients with multiple myeloma.

Recent studies have shown that treatment with bisphosphonates could be effective against the myelomatous skeletal deterioration. However, the mechanisms of action of these drugs in multiple myeloma (MM) have been poorly studied. In the present study, 11 patients with MM and bone lesions were treated orally with 30 mg/day of risedronate for 6 months, and monitored for 6 additional months. Mean serum calcium decreased from day 4, with a concomitant increase in circulating levels of PTH (1-84) and 1,25-(OH)2D. These parameters reached their nadir on day 7 and returned to baseline value during the treatment period. Markers of bone resorption, pyridinoline and deoxypyridinoline decreased from day 7; they were at 50% and 78% of their basal value at the end of treatment and follow-up periods, respectively. A significant reduction of estimates of bone formation (serum alkaline phosphatase and osteoclacin) appeared at month 3 and persisted for the remainder of the 9-month period. Histomorphometric analysis showed a significant reduction of activation frequency, number of osteoclasts and erosion depth. Bone turnover was high at baseline, and normal after treatment, without mineralisation defects. Mean wall thickness was not different before and after treatment. Spinal bone mineral density measured by dual energy X-ray absorptiometry increased (5.3%) at the end of treatment. We conclude that oral risedronate in multiple myeloma induces a noticeable and rapid inhibition of bone resorption.

Absorptiometry, Photon↗

[Management of renal trauma in the child (author's transl)].

Intravenous pyelography remains the basic examination in the study of the child with lumbar trauma. This examination has its limits, however, and renal arteriography may be necessary in a fair number of cases. Provided that adequate reflection is given and the appropriate moment chosen, it is well tolerated and provides all the necessary information.

Abdominal Injuries↗