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Biomedical subjects

P Dellenbach

Publications and source records attributed to P Dellenbach.

At least 73 records · Page 4Linked to original sources
PubMed1980

[Metabolic risks of salbutamol in diabetic patients. A study using somatostatin (author's transl)].

Salbutamol-induced diabetic ketoacidosis having recently been reported, the authors have studied the metabolic changes produced by the drug in 6 nondiabetic patients. All patients received a 3-hour infusion of salbutamol (S) 20 z g/minm. On the following day, three of these were given somatostatin (SRIF) 100 mg/hour mixed with S infused at the same rate, whilst the remaining 3 patients received SRIF alone. On the 3rd day, patients of the first sub-group received the same infection of S and SRIF as before plus exogenous glucagon 90 ng/kg/hour. Somatostatin is know to inhibit insulin and glucagon secretion. Exogenous glucagon was given in order to reproduce the metabolic conditions of insulin-deficient diabetes mellitus. Salbutamol alone induced a small rise in blood glucose and insulin, free fatty acids, glycerol and ketonic bodies, but no changes in endogenous glucagon. SRIF alone produced no significant metabolic variations. In the presence of SRIF, all salbutamol-induced metabolic changes were increased. Adding glucagon mainly resulted in high levels of ketonic bodies. All variations correlated with each other. Thus, whilst the hyperglycaemic, lipolytic and ketogenic effects of S in non-diabetic patients are partly masked by insulin hypersecretion, they are enhanced in the absence of insulin and, to an even greater extent, by an excess of glucagon. Diabetic patients treated with salbutamol should therefore be under close surveillance and have their insulin dosage increased.

Adult↗
PubMed1980

Rapid bedside estimation of plasma and whole blood lactic acid.

A rapid method for the bedside measurement of plasma, intracellular and whole blood lactates is described. The paper described a new method of measuring the L-lactate content of blood using an apparatus ("Lactate Analyzer 640", manufactured by Roche Bio-electronics, Basel) previously designed for this purpose but using aqueous solutions. A novel feature of this new method is the facility to use small blood samples (100-150 mul). We therefore believe that it will become an invaluable tool in obstetrics and neonatology.

Erythrocytes↗
PubMed1980

[Glucose tolerance on long-term treatment with a progestogen (etynodiol diacetate) (author's transl)].

Continuous long-term treatments with progestogens are able to bring about an hyperinsulinic reaction, which up till now has been considered to be due to a peripheral anti-insulin effect. Isolating the levels of immuno-reactive plasma insulin and of human C-peptide at the same time when loads of glucose and of tolbutamide are given after one another would seem to demonstrate that there is a primitive beta-islet of Langerhans origin for this hyperinsulinaemia. These results show that it is safe to prescribe etynodiol diacetate to "normal" patients as well as to "diabetic" patients.

Adult↗